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Experimental vaccine given during pregnancy reduces stillbirths from common virus

ntal guinea pig CMV vaccine—UL83, also called pp65—contains the information needed to make a protein involved in the infection process. The virus used to make the vector vaccine (Venezuelan Equine Encephalitis Virus) was altered by removing 40 percent of the virus?genes, to prevent it from reproducing and infecting new hosts.

The young female guinea pigs in the study were vaccinated three times at two-month intervals before they became pregnant and were injected with the guinea pig form of CMV early in their third trimester.

Tests showed that the rodents given the experimental vaccine had acquired immunity to guinea pig CMV because they produced antibodies to the virus—proteins that target foreign molecules for later destruction by the immune system. The vaccinated guinea pigs also showed an activity against the virus by their T cells, immune cells critical to the response against disease-causing organisms.

Dr. Schleiss said the current paper provides the basis for the potential development of a version of the vector vaccine that could be tested in human beings.
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Source:NIH/National Institute of Child Health and Human Development


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