Navigation Links
Experimental vaccine given during pregnancy reduces stillbirths from common virus

Researchers funded by the National Institutes of Health have developed an experimental vaccine that reduces stillbirths among rodents born to mothers infected with cytomegalovirus (CMV)—a common virus that can also cause mental retardation and hearing loss in newborn children who were infected in early fetal life.

Estimates place the number of U.S. children born with CMV each year at about 40,000, and there is no vaccine or treatment for pregnant women who have the infection. In a 2000 report, the Institute of Medicine of the National Academy of Sciences listed as a top priority the development of a vaccine to prevent cytomegalovirus during pregnancy.

"An effective CMV vaccine for women of childbearing age could greatly reduce the disability caused by the virus," said Duane Alexander, M.D., Director of the NICHD, the NIH institute that funded the study. "A prototype vaccine is the first step in protecting newborns against the most common viral disease of newborns in the developed world."

The study appears in the March 15, 2007, issue of the Journal of Infectious Diseases.

Mark Schleiss, M.D., American Legion Endowed Chair in Pediatric Infectious Diseases at the University of Minnesota School of Medicine, led a team of researchers at his own and other institutions to conduct the study.

Female guinea pigs given the CMV vaccine before becoming pregnant gave birth to fewer dead pups and were less likely to transmit the infection to their offspring than were female guinea pigs not receiving the vaccine.

The vaccinated group (10 litters) produced 28 live pups and 4 dead pups—a mortality rate of 13 percent. The control group (8 litters), which received a vaccine for the flu, produced 9 live pups and 12 dead pups—a mortality rate of 57 percent.

The surviving pups weighed more than the pups of mothers that had not received the CMV vaccination before becoming pregnant. The vaccine greatly reduced the to
'"/>

Source:NIH/National Institute of Child Health and Human Development


Page: 1 2 3

Related biology news :

1. NIAID Initiates Trial of Experimental Avian Flu Vaccine
2. Experimental shingles vaccine proves effective in nationwide study
3. Experimental vaccine protects nonhuman primates when given after exposure to Marburg virus
4. Experimental TB drug effective against resistant and latent mycobacterium tuberculosis
5. Experimental drug reverses key cognitive deficits, pathology in Alzheimers
6. Experimental RNA-based drug kills prostate cancer cells effectively and safely
7. Experimental vaccine protects lab animals against several strains of H5N1
8. Experimental vaccine protects mice against deadly 1918 flu virus
9. Experimental cancer drugs counter muscle deterioration seen in muscular dystrophy
10. Research advances quest for HIV-1 vaccine
11. A much-needed shot in the arm for HIV vaccine development
Post Your Comments:
(Date:7/22/2014)... contrast to their negative reputation as disease causing ... evolutionary functions that help to shape the world ... report by the American Academy of Microbiology. , ... all life forms on the planet, from contributing ... driving major speciation events," states Marilyn Roossinck of ...
(Date:7/22/2014)... multinational, collaborative effort, researchers from the Icahn School of ... locations in the human genome associated with the risk ... on any psychiatric disorder to date, conducted with 80,000 ... point to biological mechanisms and pathways that may underlie ... the disorder, which has seen little innovation in drug ...
(Date:7/22/2014)... as a world-famous vacation spot with natural tourism resources, a ... The Korea Institute of Geoscience and Mineral Resources (KIGAM) indicated ... volcanic eruption was evident 5,000 years ago. That is the ... spewed out of a volcano 5,000 years ago in the ... the whole peninsula. , The research team led by Dr. ...
Breaking Biology News(10 mins):Report on viruses looks beyond disease 2Mount Sinai scientists and international team shed new light on schizophrenia 2Mount Sinai scientists and international team shed new light on schizophrenia 3Jeju Island is a live volcano 2
... than females are born worldwide every year. In recent decades, ... there has been an apparent decline in the ratio of ... Denmark, England, Germany, Japan and the United States. That has ... influence the probability of giving birth to a baby boy ...
... a pollen allergy, an 18-acre ragweed field sounds like ... environmental engineering researchers at The Johns Hopkins University, the ... how the troublesome weeds grow, reproduce and scatter their ... with a mix of high-tech and low-tech tools, could ...
... CORVALLIS, Ore. Generations of studies on vitamin E ... has demonstrated that the levels of this micronutrient necessary ... that have been commonly used in clinical trials. ... Biology and Medicine, researchers concluded that the levels of ...
Cached Biology News:Weight gain between first and second pregnancies associated with increased odds of male second child 2Ragweed research is nothing to sneeze at 2Ragweed research is nothing to sneeze at 3Ragweed research is nothing to sneeze at 4Vitamin E trials 'fatally flawed' 2Vitamin E trials 'fatally flawed' 3
(Date:7/22/2014)... SHENZHEN , Cina, 22 luglio 2014 ... di BGI, la maggiore organizzazione di genomica del mondo, ... di sequenziamento dell,intero esoma umano con base la piattaforma ... Complete Genomics, molto apprezzata nel settore per essere in ... 99.999% di precisione e una rilevazione altamente sensibile di ...
(Date:7/22/2014)...  Semler Scientific, Inc. (Nasdaq: SMLR ... that develops patented products that assist healthcare providers ... announced that it will report second quarter 2014 ... markets on July 25, 2014. Doug Murphy-Chutorian, M.D., chief executive ... at 11 a.m. EDT, July 25, 2014. The ...
(Date:7/22/2014)... Jersey , 22. Juli 2014 ... Life-Sciences-Industrie, hat die Ernennung von Marcus Bergler zum ... Herr Bergler hat die europäischen kommerziellen Aktivitäten von ... Bevor er sich Qforma anschloss, war er in ... Customer Information, als Vertriebsteam-Leiter Deutschland bei IMS Health ...
(Date:7/21/2014)... 21, 2014 With a larger, ... the new Cole-Parmer® Digital Gear Pump Drive ... to operate for automated process applications. , Simply ... The batch count function counts down and displays ... tracks amount dispensed across multiple cycles. View the ...
Breaking Biology Technology:BGI Tech lancia un servizio di sequenziamento dell'intero esoma umano sulla piattaforma avanzata di Complete Genomics 2Semler to Report Second Quarter 2014 Financial Results and Host Conference Call on July 25, 2014 2Qforma gibt Schaffung des neuen Postens als General Manager in Europa bekannt 2New Easy-View Cole-Parmer Digital Gear Pump Drive Makes Performance Monitoring Effortless 2
... Russell J. Buono and Paul J. Linser, Whitney Marine,Laboratory, ... , , ... a powerful tool , in the study ... of microinjection of foreign DNA into fertilized embryos is tedious and , ...
, , , , , , , back to top...
... Mortimer, Human Genome Center, Division,of Cell and Molecular Biology, Lawrence Berkeley Laboratory,Berkeley, California ... Introduction , ... been performed by a PEG-spheroplast procedure. ... is complicated, often unreliable, and transformation efficiencies are , ...
Cached Biology Technology:Transgenic Zebrafish by Electroporation 2Transgenic Zebrafish by Electroporation 3Transgenic Zebrafish by Electroporation 4Transgenic Zebrafish by Electroporation 5Electroporation of Yeast Artificial Chromosomes 2Electroporation of Yeast Artificial Chromosomes 3Electroporation of Yeast Artificial Chromosomes 4
... Agilent Technologies introduces an ... Series ICP-MS for Windows 2000 ... (OS). From September 2003, all ... be controlled by the new ...
... handy dispensers save space and organize ... other garb. They are the perfect ... used in labs, processing and manufacturing. ... and the particles they attract. Many ...
... critical to the maintenance of appropriate ... as important and diverse as those ... and stress response, antigen presentation, modulation ... channels, cell cycle regulation, transcription, and ...
... Normal Pooled Human Serum • Human ... who are found to be negative by ... (s) (HIV-1Ag), Antibodies to Human Immunodeficiency Virus ... Nonreactive for Hepatitis B Surface Antigen (HbsAg) ...
Biology Products: