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Experimental shingles vaccine proves effective in nationwide study

of postherpetic neuralgia (PHN)--a form of chronic nerve pain that is the most common serious complication of shingles--by two-thirds compared with placebo. The vaccine was well tolerated, with the rates of serious adverse events low and local reactions at the vaccination site generally mild.

"As people live longer, and the proportion of older people in our population increases, it is highly likely that the prevalence of shingles will increase. A preventive shingles vaccine would be an enormous boon for the health and quality of life of seniors," says Anthony S. Fauci, M.D., NIAID director. "We are extremely gratified that this public-private partnership has led to these exciting results, which have the potential to greatly benefit seniors in years to come."

Approximately 12 percent of older people with shingles experience pain lasting for 3 months or longer (the definition of PHN used in the study). As people age, however, shingles-associated nerve pain increases in frequency and severity. This complication may occur in nearly one-third of persons with shingles who are 60 years of age or older.

Patients with PHN often describe the pain as burning, throbbing, aching, stabbing or shooting, and it can cause both physical and emotional suffering. What can be most distressing and debilitating, according to these patients, is that at least 90 percent of them have allodynia--pain caused by something that ordinarily is not painful, such as clothing touching the skin, or a cool breeze. Simply dressing and having a shirt touch the side of the body that is affected can be excruciating.

Postherpetic neuralgia is difficult to treat. Antiviral medications can speed the healing of shingles and reduce the severity of nerve damage caused by the disease, but only if these medications are used within 72 hours of the first sign of a shingles rash. Thus, it is important for people to recognize the symptoms of shingles and get to a doctor quickly. Antivi
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Source:NIH


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