Navigation Links
Experimental gene therapy 'abolishes' arthritis pain and lessens joint damage

Early-stage research has found that a new gene therapy can nearly eliminate arthritis pain, and significantly reduce long-term damage to the affected joints, according to a study published today in the journal Arthritis and Rheumatism. While the study was done in mice, they are the first genetically engineered to develop osteoarthritis like humans, with the same genetic predisposition that makes some more likely to develop the disease, the authors said. If all goes well with a follow-up study currently underway, researchers will apply to the U.S. Food and Drug Administration for permission to begin human trials next year.

Nearly everyone aged 65 or older suffers from the pain, swelling and permanent joint damage of osteoarthritis. The most common form of arthritis, it develops over time following initial joint injuries or just as a result of aging. In the current study, researchers found that one injection of a newly designed gene therapy relieved 100 percent of osteoarthritic pain in the study model. In addition, researchers were surprised to find that the therapy also brought about a nearly 35 percent reduction in permanent structural to joints caused by round and after round of osteoarthritic inflammation.

To date, treatment of arthritis is dominated by drug treatments like non-steroidal, anti-inflammatory drugs, COX-2 inhibitors and acetominophen. Morphine and its derivatives are still in common use as well, but can depress breathing and lead to addiction. Taken together, current treatments deliver inconsistent results and new approaches are needed, researcher said. Gene therapy has been attempted in the past, but older, invasive techniques required that therapeutic genes be injected directly into nerve cells. Strong pain relief resulted, but in some cases the injections caused nerve damage.

"Our publication represents the first proof that gene therapy can work in a way that is clinically applicable," said Stephanos Kyrkanides, D.D.
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3 4

Related biology news :

1. NIAID Initiates Trial of Experimental Avian Flu Vaccine
2. Experimental shingles vaccine proves effective in nationwide study
3. Experimental vaccine protects nonhuman primates when given after exposure to Marburg virus
4. Experimental TB drug effective against resistant and latent mycobacterium tuberculosis
5. Experimental drug reverses key cognitive deficits, pathology in Alzheimers
6. Experimental RNA-based drug kills prostate cancer cells effectively and safely
7. Experimental vaccine protects lab animals against several strains of H5N1
8. Experimental vaccine protects mice against deadly 1918 flu virus
9. Experimental cancer drugs counter muscle deterioration seen in muscular dystrophy
10. Experimental vaccine given during pregnancy reduces stillbirths from common virus
11. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
Post Your Comments:
(Date:10/13/2008)...arch may help reveal why different parts of the br...e sclerosis (MS). According to a new study in mice...a protein produced by invading T cells dictates wh...s under fire. The studyfrom researchers at the Uni...e and Washington University in St. Louiswill be pu...
(Date:10/12/2008)...ng up excess neurotrophic factor from neuronal syn...ssion to affect processes such as learning and mem...nts of learning and memory are long-term potentiat...which affect neurons, ability to communicate with ...ay a stronger electrical response to the same leve...
(Date:10/12/2008)...elease is also available in French . , Resear...and GlaxoSmithKline Inc. have identified two genet... astounding sevenfold increase the risk of male pa...t. 12 in the journal Nature Genetics. , About ...ldness by age 45. The condition,s social and econo...
(Date:10/12/2008)...s week Nature Nanotechnology journal (October 12...for Nanotechnology (LCN) at UCL are using a novel ...s of vancomycin, one of the few antibiotics that c...ions such as MRSA. The researchers, led by Dr Rach...d ultra-sensitive probes capable of providing new ...
Breaking Biology News(10 mins):Astrocytes and synaptic plasticity 2Researchers discover baldness gene: 1 in 7 men at risk 2Nanotechnology boosts war on superbugs 2Otter Tail Corporation Holds 2008 Annual Meeting 3A Shareholders Elect Directors 3B Board Declares Quarterly Dividend 16788 1Otter Tail Corporation Holds 2008 Annual Meeting 3A Shareholders Elect Directors 3B Board Declares Quarterly Dividend 16788 2Otter Tail Corporation Holds 2008 Annual Meeting 3A Shareholders Elect Directors 3B Board Declares Quarterly Dividend 16788 3CryoLife Announces Release Date and Teleconference Call Details for First Quarter 2008 Financial Results 16786 1CryoLife Announces Release Date and Teleconference Call Details for First Quarter 2008 Financial Results 16786 2PA Department of Health Warns Consumers About Adverse Reactions From Dietary Supplements 16784 1PA Department of Health Warns Consumers About Adverse Reactions From Dietary Supplements 16784 2Boston Scientific Announces Japanese Approval of Heart Failure Lead 4582 1Boston Scientific Announces Japanese Approval of Heart Failure Lead 4582 2Boston Scientific Announces Japanese Approval of Heart Failure Lead 4582 3
...tists looked to ferns to create a novel energy sca...to move itself---materials that could provide a me... water or heat. , "We,ve shown that this idea work...lectrical engineering and computer science and pri...vice. "If you build these things they will move. T...
...State University researchers have developed two ne...boratory. , The first patent-pending technology pr...cer cells in the laboratory are responding to an a...veral sets of cells at once -- allows for the simu...ct of a single drug on different kinds of cells ta...
... research will get a boost tomorrow (14 October) a...on nerve cell analysis software at Neuroscience 20...ence for brain researchers. , HCA-Vision is based ...Australia,s CSIRO, for automatically tracing and m...40,000 delegates expected, the conference will be ...
...or take a few dozen trillions, a human adult has a...legans roundworm has exactly 959 cells. , Yet we ...y of Duke University, who has been exploring two “...te immunity shared by worms and humans. For one, w...-borne pathogens. C. elegans, of course, lives in ...
Other Biology News:Ferns provide model for tiny motors powered by evaporation 2Chemical tests of cell growth enter third dimension 2Chemical tests of cell growth enter third dimension 3Worms produce surprise insight into human fever 2
(Date:10/13/2008)... No Child Should Die of Diabetes, BRUSSE...iabetes,Federation (IDF) announced today that it i...r action to secure care for the thousands of child...access to care., The meeting, Access to Essential... World, will be held on Saturday, October 25 in Lo...
(Date:10/13/2008)...Mass., Oct. 13 /- Thursday ...g in Boston Scientific,s (NYSE: BSX ),stock. As a...se, a,significant portion of this trading was due ...by Boston Scientific,s co-founders Pete Nicholas a...iday, approximately 31,million shares in aggregate...
(Date:10/13/2008)...ARA, Calif., Oct. 13 /- WebLOQ, Inc.,...r secure and compliant eBusiness and,data-in-motio...ine and,Joint has deployed the WebLOQ ePrivacy sol...he center, along with their healthcare partner, th...al practices, has,implemented WebLOQ,s hosted, on ...
(Date:10/13/2008)...N-LE-PONT, France, October 13 /PRNewswire-FirstCal...precedent, Essilor has now,completed the acquisiti...AG, the world leader in prescription optical equip...e coating units and surfacing,machines, as well as...ported EUR161 million in revenue in 2007 and emplo...
Breaking Biology Technology:International Diabetes Federation Calls for Global Action to Keep All Children With Diabetes Alive 2International Diabetes Federation Calls for Global Action to Keep All Children With Diabetes Alive 3Boston Scientific Provides Update on Involuntary Selling of Its Stock by Co-Founders 2Boston Scientific Provides Update on Involuntary Selling of Its Stock by Co-Founders 3Monterey Spine and Joint Deploys WebLOQ ePrivacy Solution for HIPAA Compliant Health Information Exchange 2Monterey Spine and Joint Deploys WebLOQ ePrivacy Solution for HIPAA Compliant Health Information Exchange 3
...s in chains. Fail to develop the talents of any on...wealth. This quotation is taken from Tony Blairs L...n 1999. It opens chapter one of The Mismanagement ... forthcoming book by British HR researchers Anthon...e main focus of their research was on how universi...
...automatic inventory tracking are not quite here ye...company ePC Group , has a few words to say about ... eInnovate and UW E-Business Institute held June ...s from retailers such as Wal-Mart to implement RFI...ahead of the pack. For others, an RFID implementat...
...lectric Company, recently announced the first pati..., at Froedtert Hospital in Milwaukee. , ,The Lig...organ in one second, scan the whole body in less t... coronaries in fewer than five heartbeats. , ,In a...s, totaling 40 millimeters of anatomical coverage....
... way to summer heat, long weekends and beach vacat...on the nightstand and imagine that we,ll have just...eading. , ,Recently, I had occasion to ask a numbe...gathered up their responses both classic business...etter Summer Reading List: , , A Short History of ...
Other Biology Technology:Talent Mismanagement 2Talent Mismanagement 3RFID: a 30-year project 2New CT scanner by GE Healthcare advances imaging technology 2DEMOletter's Summer Reading List 2DEMOletter's Summer Reading List 3DEMOletter's Summer Reading List 4
Whole blood is collected from canines (any breed, either sex), refrigerated within 6 hours, processed within 24 hours and frozen at -20C.
Designed for flow cytometric applications intended to identify
MOUSE ANTI RAT RT1Bu Immunogen: Rat thymocyte membrane glycoproteins
RABBIT ANTI HUMAN CYTOCHROME P450 1A1/2 Immunogen: Purified human CYP1A2 expressed in E.Coli
Biology Products: