Navigation Links
Experiment station researchers to explore genome of disease-fighting fungus

A team of Texas Agricultural Experiment Station scientists will soon begin genome sequencing a disease-fighting fungus used to protect crops, which has implications for both agriculture and the pharmaceutical industry.

The fungus, Trichoderma virens, is used to protect field crops from various plant diseases. Researchers say the genome sequencing work may uncover chemical compounds and beneficial genes useful in producing new human and animal antibiotics.

The sequencing project is a collaborative effort with the Department of Energy Joint Genome Institute. Experiment Station plant pathologists are Drs. Charles M. Kenerley, Daniel J. Ebbole, Heather H. Wilkinson and Michael Thon. Also working on the project is Dr. Alfredo Herrera-Estrella, from the Center for Research and Advanced Studies in Mexico.

"There's both pharmaceutical and agricultural implications," said Kenerley, who is the lead researcher on the project. "We're going to get a view of all of the genes that might be responsible for producing antibiotics and potentially discover novel antibiotics used in therapy for humans or animals.

"We know some of the genes responsible for known antibiotics, however, there are additional genes in Trichoderma responsible for producing uncharacterized compounds that might be novel antibiotics."

By sequencing the fungus, researchers say they will be able to develop new versions of the fungus to protect field crops from diseases. This would decrease the amount of pesticide and other chemicals applied throughout a growing season.

"You also might be able to more effectively employ sustainable practices such as low till agriculture," said Wilkinson, who is researching the ecological aspects of the fungus. "You've got Trichoderma present to combat the pathogens that remain in the soil when you incorporate low till. In theory, it would be cost-effective for many producers.

"By placing the disease-fighting fungus directly onto the seed, it would continue to protect the plant throughout the growing season and spread throughout the root system."

Finding unique genes involved in inducing plant resistance could also aid the greenhouse industry that encounters problems with seedling rot in different plant varieties.

"In the nursery industry where you transplant from smaller to larger containers, you can incorporate the fungus as a potting mix amendment that would protect against root-rotting fungi," Kenerley said.

Ebbole said their research will "provide resources for the entire scientific community," noting all of the analysis will be shared with other scientists to further other projects.

"Texas A&M researchers will have priority in annotating the sequence and publishing the findings," Ebbole said.

The project is one of 40 new genome projects announced Thursday by the Department of Energy Joint Genome Institute.

"Through the Community Sequencing Program, we are leveraging the dramatic advances in genomic technology accrued since DOE launched the Human Genome Project nearly 20 years ago," said Dr. Raymond L. Orbach, director of the Department of Energy's Office Of Science. "Our ability to generate DNA sequences, particularly over the last three years, has approached Moore's Law of proportions ?in effect doubling every 18 months. These advances have led DOE JGI to emerge as one of the preeminent contributors to microbial and plant genomics."


'"/>

Source:Texas A&M University - Agricultural Communications


Related biology news :

1. Experiments provide proof of how traveling in groups protects insects
2. Experiments provide proof of how traveling in groups protects insects
3. NIAID Initiates Trial of Experimental Avian Flu Vaccine
4. Duke Experiments Boost Radiations Cancer-Killing Effects
5. Experimental shingles vaccine proves effective in nationwide study
6. Experimental vaccine protects nonhuman primates when given after exposure to Marburg virus
7. Experimental TB drug effective against resistant and latent mycobacterium tuberculosis
8. Experimental drug reverses key cognitive deficits, pathology in Alzheimers
9. Experimental RNA-based drug kills prostate cancer cells effectively and safely
10. Experimental vaccine protects lab animals against several strains of H5N1
11. Experimental vaccine protects mice against deadly 1918 flu virus
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/4/2017)... BLOOMINGTON, Ill. , Oct. 4, 2017  GCE Solutions, a ... powerful new data and document anonymization solution on October 4, 2017. ... the pharmaceutical field to comply with policy 0070 of the European ... documents and data. ... Innovation by GCE Solutions ...
(Date:8/15/2017)... Aug. 15 2017   ivWatch LLC , a medical device ... therapy, today announced receipt of its ISO 13485 Certification, the global ... International Organization for Standardization (ISO®). ... ivWatch Model 400 Continuous Monitoring device for the early detection of ... "This is an important milestone ...
(Date:6/30/2017)... Va. , June 30, 2017 ... leading developer and supplier of face and eye ... ATA Featured Product provider program. ... an innovative way to monitor a driver,s attentiveness ... greatly from being able to detect fatigue and ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... AMRI, a global contract research, ... improve patient outcomes and quality of life, will now be offering its impurity ... to new regulatory requirements for all new drug products, including the finalization of ...
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 ... overexpression experiments and avoiding the use of exogenous expression plasmids. The simplicity of ... performing systematic gain-of-function studies. , This complement to loss-of-function studies, such as ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... today it will be hosting a Webinar titled, “Pathology is going digital. Is ... , on digital pathology adoption best practices and how Proscia improves lab economics ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are the ... million people each year. Especially those living in larger cities are affected by air ... one of the most pollution-affected countries globally - decided to take action. , “I ...
Breaking Biology Technology: