Navigation Links
Experience affects new neuron survival in adult brain; study sheds light on learning, memory

Experience in the early development of new neurons in specific brain regions affects their survival and activity in the adult brain, new research shows. How these new neurons store information about these experiences may explain how they can affect learning and memory in adults.

A team of researchers headed by Fred Gage, PhD, of the Salk Institute, found that experience enhances the survival of new neurons in a brain area called the dentate gyrus, and that more of these new neurons were activated when exposed to the same experience later. This change in function may be a mechanism for long-term memory. The findings are published in the March 21 issue of The Journal of Neuroscience.

"The results identify a critical period for experience-induced enhancement of new neuron survival in the hippocampus," says Elizabeth Gould, PhD, of Princeton University, who was not affiliated with the study. The hippocampus contains the dentate gyrus.

After injecting mice with a chemical used to mark proliferating cells, the researchers exposed the animals to an "enriched cage" environment, containing tunnels, shelters, and a running wheel. After several weeks, the researchers again exposed the mice in the same enriched experience. They discovered that the enriched experience increased new neuron survival and that more new neurons were activated by re-exposure to the same environment. To determine if the increase in neuronal activity was due to having the same experience or if any new experience was sufficient to achieve this effect, the researchers exposed mice to the enriched cage first and then a water maze task. While both cases promoted new neuron survival, more new neurons were activated in mice that had repeated the same experience but not in those that were exposed to the different experience (the water maze).

The researchers also compared the number of neurons at four weeks and four months after injections of the chemical mar ker. This comparison indicates that only young neurons are affected by the repeated experience; once new neurons survive the early period of development, their long-term survival and activity become stable. This suggests that the information on the experience is kept for a long time, says Gage.

"This finding indicates the way in which new neurons in the adult brain could contribute to learning and memory by storing the information of one’s previous experiences," Gage says. Future research, he says, should focus on understanding when new neurons are active during memory-related behavior, how experience affects this activity, and what the consequences are for other brain regions.
'"/>

Source:Society for Neuroscience


Related biology news :

1. Cytoplasm affects the number of vertebrae in carp-goldfish clones
2. Clam embryo study shows pollutant mixture adversely affects nerve cell development
3. Road salt affects mitigation wetlands
4. Exercise training in ordinary people affects the activity of 500 genes
5. Enzyme affects hypertension by controlling salt levels in body
6. Tropical Deforestation affects rainfall in the U.S. and around the globe
7. New study examines how sense of smell affects mating and aggression in mice
8. Gene variation affects tamoxifens benefit for breast cancer
9. New discovery: Molecular variation in one gene affects the growth of natural populations
10. UMaine teams with fishermen to study affects of trawling on seafloor ecology
11. Memory loss affects more of the brain than previously thought

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2017)...   ivWatch LLC , a medical device company focused on ... receipt of its ISO 13485 Certification, the global standard for medical ... Standardization (ISO®). ... Continuous Monitoring device for the early detection of IV infiltrations. ... "This is an important milestone for ivWatch, as ...
(Date:5/23/2017)... 2017  Hunova, the first robotic gym for the rehabilitation and functional ... in Genoa, Italy . The first 30 robots will ... USA . The technology was developed and patented at ... IIT spin-off Movendo Technology thanks to a 10 million euro investment from ... click: ...
(Date:4/19/2017)... 19, 2017 The global military ... is marked by the presence of several large global ... by five major players - 3M Cogent, NEC Corporation, ... for nearly 61% of the global military biometric market ... the global military biometrics market boast global presence, which ...
Breaking Biology News(10 mins):
(Date:9/22/2017)... ... September 22, 2017 , ... The Academy ... Colorado October 28 and 29, 2017, to promote AMA’s programs, member services, and ... in different hobbies, including but not limited to model aviation and other RC ...
(Date:9/21/2017)... ... September 21, 2017 , ... Dr. Greg Leyer, Chief Scientific ... on September 27th. His presentation is at 12:10pm in the Probiotics Resource Center, Mandalay ... at SupplySide West and discuss how probiotics have shown impressive data in areas outside ...
(Date:9/21/2017)... UK (PRWEB) , ... September 21, 2017 , ... ... a QuintilesIMS company, who enable the world’s most progressive pharma and biotech organizations ... clinical trials at top pharma and biotech events in Q4. , DrugDev will ...
(Date:9/21/2017)... ... September 21, 2017 , ... Lajollacooks4u welcomed the San ... The organization, a worldwide society of professional women with high achievement in the fields ... annual dinner. , Twelve members began with an olive oil tasting to ...
Breaking Biology Technology: