Navigation Links
Expanding waistlines triggered by your genes

A gene that degrades the body's collagen infrastructure has been shown to make fat cells fatter and expand girth.

Excess fat is stored in white adipose tissue, the primary energy depot in the body, primarily around the midsection. The gene studied by a University of Michigan team acts as a metabolic scissors, cutting through the collagen tissue matrix that holds fat in place, which allows fat cells to expand beneath the belly.

The collaborative research team, headed by researchers Tae-Hwa Chun, Stephen Weiss, and Alan Saltiel at U-M's Life Sciences Institute (LSI), discovered that the gene membrane-type 1 matrix metalloproteinase (MT1-MMP) shears the collagen meshwork that holds fat cells in place and frees expanding fat cells, allowing their spread and expansion underneath the skin. The study illustrates a relationship between the gene and obesity and metabolism.

The MT1-MMP gene is specifically important in regulation of fat cell size and metabolic gene expression. When the gene function was deleted, mice became skinny. The fat tissues around their bellies were very small, but the brown adipose tissue, a specialized fat depot to regulate body energy consumption, was unaffected.

Importantly, the research team also discovered that adipocyte differentiation in conventional two-dimensional (2-D) cell culture is different from three-dimensional (3-D) microenvironment taking place inside the complex body. In regular 2-D culture system, the MT1-MMP gene was not necessary, but it becomes a critical metabolic scissors once cells are inside 3-D environment either in collagen gel or in the real tissue of mouse. This finding may fill a gap between conventional 2-D cell biology and 3-D tissue function.

These findings shed new light on adipocyte biology and possibly will provide novel therapeutics to prevent the progression of obesity. The researchers will continue to work on the cellular mechanism of obesity and metabolic diseases from the perspective of 3-D cell biology.


'"/>

Source:University of Michigan


Related biology news :

1. Expanding forests darken the outlook for butterflies, study shows
2. Opposing fat metabolism pathways triggered by a single gene
3. Autoimmune disease triggered if T cells miss a single protein early on
4. Scientists document complex genomic events leading to the birth of new genes
5. Advances in the characterisation of the oyster mushroom genes
6. Compounds in plastic packaging act as environmental estrogens altering breast genes
7. Where bacteria get their genes
8. NYU, Rockefeller researchers find complexity of regulation by microRNA genes
9. Exercise training in ordinary people affects the activity of 500 genes
10. Carnegie Mellon University research reveals how cells process large genes
11. Sleeping beauty plays a significant role in identifying cancer genes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... Janice Kephart , former 9/11 ... Partners, LLP (IdSP) , today issues the following ... March 6, 2017 Executive Order: Protecting the ... be instilled with greater confidence, enabling the reactivation ... applications are suspended by until at least July ...
(Date:4/19/2017)... 19, 2017 The global military ... is marked by the presence of several large global ... by five major players - 3M Cogent, NEC Corporation, ... for nearly 61% of the global military biometric market ... the global military biometrics market boast global presence, which ...
(Date:4/18/2017)... SUNNYVALE, Calif. , April 18, 2017  Socionext Inc., a ... prototype of a media edge server, the M820, which features the ... face recognition software provided by Tera Probe, Inc., will be showcased ... and at the NAB show at the Las Vegas ... ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... ... 2017 , ... Dr. Robert G. Schwartz, the principal of ... that acclaimed physiatrist Matthew Terzella, MD, has joined the practice as a partner, ... completed his residency in Physical Medicine and Rehabilitation at UMDNJ-Robert Wood Johnson and ...
(Date:4/25/2017)... ... April 25, 2017 , ... ... , Covalent’s Analytical Services unit provides high-quality data to clients, both ... 24 hours of receipt. There are no price premiums, and customers are welcome ...
(Date:4/25/2017)... ... ... Leaders of Quorum Review IRB and Kinetiq , the ... week’s Association of Clinical Research Professionals (ACRP) 2017 Meeting & Expo with ... are excited to present subject matter expertise on topics that impact the global clinical ...
(Date:4/24/2017)... ... April 24, 2017 , ... ... in a cellular milieu; however, the broad application of this cellular target engagement ... with sensitive quantitative readouts. Cell-based thermal stabilization assays are valuable methods for particular ...
Breaking Biology Technology: