Navigation Links
Expanding waistlines triggered by your genes

A gene that degrades the body's collagen infrastructure has been shown to make fat cells fatter and expand girth.

Excess fat is stored in white adipose tissue, the primary energy depot in the body, primarily around the midsection. The gene studied by a University of Michigan team acts as a metabolic scissors, cutting through the collagen tissue matrix that holds fat in place, which allows fat cells to expand beneath the belly.

The collaborative research team, headed by researchers Tae-Hwa Chun, Stephen Weiss, and Alan Saltiel at U-M's Life Sciences Institute (LSI), discovered that the gene membrane-type 1 matrix metalloproteinase (MT1-MMP) shears the collagen meshwork that holds fat cells in place and frees expanding fat cells, allowing their spread and expansion underneath the skin. The study illustrates a relationship between the gene and obesity and metabolism.

The MT1-MMP gene is specifically important in regulation of fat cell size and metabolic gene expression. When the gene function was deleted, mice became skinny. The fat tissues around their bellies were very small, but the brown adipose tissue, a specialized fat depot to regulate body energy consumption, was unaffected.

Importantly, the research team also discovered that adipocyte differentiation in conventional two-dimensional (2-D) cell culture is different from three-dimensional (3-D) microenvironment taking place inside the complex body. In regular 2-D culture system, the MT1-MMP gene was not necessary, but it becomes a critical metabolic scissors once cells are inside 3-D environment either in collagen gel or in the real tissue of mouse. This finding may fill a gap between conventional 2-D cell biology and 3-D tissue function.

These findings shed new light on adipocyte biology and possibly will provide novel therapeutics to prevent the progression of obesity. The researchers will continue to work on the cellular mechanism of obesity and metabolic diseases from the perspective of 3-D cell biology.


'"/>

Source:University of Michigan


Related biology news :

1. Expanding forests darken the outlook for butterflies, study shows
2. Opposing fat metabolism pathways triggered by a single gene
3. Autoimmune disease triggered if T cells miss a single protein early on
4. Scientists document complex genomic events leading to the birth of new genes
5. Advances in the characterisation of the oyster mushroom genes
6. Compounds in plastic packaging act as environmental estrogens altering breast genes
7. Where bacteria get their genes
8. NYU, Rockefeller researchers find complexity of regulation by microRNA genes
9. Exercise training in ordinary people affects the activity of 500 genes
10. Carnegie Mellon University research reveals how cells process large genes
11. Sleeping beauty plays a significant role in identifying cancer genes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/13/2017)... 2017 Future of security: Biometric Face Matching software  ... ... DERMALOGs Face Matching enables to match face pictures against each other or ... individuals. (PRNewsFoto/Dermalog Identification Systems) ... "Face Matching" is the fastest software for biometric Face Matching on the market. ...
(Date:3/7/2017)... LAKE CITY , March 7, 2017   ... that help top global companies identify the best talent, ... as Chief Sales Officer (CSO) and Diana ... Kucer,s appointments round out a seasoned executive team poised to ... and beyond, building on a year of record bookings ...
(Date:3/2/2017)... Who risk to be deprived of its ... report: https://www.reportbuyer.com/product/4313699/ WILL APPLE AND SAMSUNG ... Fingerprint sensors using capacitive technology represent a fast growing ... forecasts an increase of 360% of the number of ... fingerprint sensor market between 2014 and 2017 (source : ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... ... March 22, 2017 , ... Researchers face ... small lab samples to full-size tissues, bones, even whole organs to implant in ... that delivers blood deep into the developing tissue. , Current bioengineering techniques, ...
(Date:3/22/2017)... --  iSpecimen ®, the marketplace for human ... (DPS), a full-service anatomic pathology reference lab serving ... , has joined a program offered by iSpecimen ... to make human biospecimens and associated data available to ... in 2015 as a collaboration between iSpecimen and DHIN, ...
(Date:3/22/2017)... 2017   VWR (NASDAQ: VWR), ... and service solutions to laboratory and production ... EPL Archives, Inc., an international biorepository services ... regulated product research, development and commercialization lifecycle ... ancillary services. EPL Archives is widely recognized ...
(Date:3/22/2017)... ... 21, 2017 , ... Aqua Design Innovations (ADI) has launched ... over $30,000 in the first 40 minutes of crowdfunding. EcoQube is a living ... and affordably, anywhere. , “Simply add fertilized water and in less than 10 ...
Breaking Biology Technology: