( ormation could help modify that approac...)Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits

ormation could help modify that approach to drug discovery. "Maybe the target protein has a good and necessary role in 10 interactions, but the 11th is the only one we would need to eliminate," said Ideker. "What we really want are drugs that interfere with just that one disease-causing interaction."

Systems biologists such as Ideker say their ultimate goal is a comprehensive computer model of how cells work. A description of all protein-interaction circuits would make such a model possible. "We'd like to simulate diseased cell types, such as cancer cells, and then simulate the effects of drugs on those diseased cells," said Ideker. "Ultimately, we think this kind of a systems biology approach will have a very beneficial impact on drug design and human health."

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Source:University of California - San Diego


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