Navigation Links
Evolution and the workaround

Living things are resourceful, which is a comforting thought unless the living thing in question is a pathogen or a cancer cell. Noxious cells excel at developing drug resistance, outwitting immune systems, and evading cellular controls. They even show an unhealthy talent for surviving internal perturbations such as mutations that affect the function of vital genes, and they do this by evolving new mechanisms to perform old tasks. Somehow the bad guys find a workaround.

That observation led Norman Pavelka, Giulia Rancati, and Rong Li, researchers at the Stowers Institute for Medical Research in Kansas City, MO, to step back and consider the basic process by which cells adapt to the loss of seemingly irreplaceable genes. The researchers reasoned that understanding how cells adapt to internal perturbations could offer insight into how pathogens and cancer cells mutate to evade the body’s defenses and resist treatment with drugs.

The Stowers researchers used the benign budding yeast Saccharomyces cerevisiae as their model organism and deleted a key cell division gene called MYO1. Surely, eliminating this important gene would shut down cell division. This seemed to be the case in the beginning, and yet as the MYO1 defective cells were cultured and subjected to consecutive rounds of selection for best growers, the yeast came up with new strategies to carry out division. When the researchers analyzed the genetic content of these evolved strains, they found that those who were best at cell division had accumulated multiple copies of many of their chromosomes.

Intriguingly, cancer cells also accumulate extra chromosomes as they become more aggressive. The theory is that these extra chromosomes provide “backup?copies of important genes, allowing the original copies to mutate in ways that help the cells survive stresses (such as drugs) that are meant to kill them.

The observation that both yeast and cancer cells evolve chr omosome duplications to work around lethal stresses suggests that drugs aimed at defeating this process might be particularly effective against pathogens and cancers adept at rapid drug resistance, the researchers say.

To stay alive, you have to be both sturdy and flexible. The Stowers researchers look to these evolved yeast strains for future explanations of how the duplication of genetic information contributes to the robustness and adaptability of all living things.


'"/>

Source:American Society for Cell Biology


Related biology news :

1. To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists
2. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
3. Evolution of life on Earth may hold key to finding life in outer space
4. Evolutionary conservation of a mechanism of longevity from worms to mammals
5. Evolutionary biology research techniques predict cancer
6. Evolutionary shifts in olfactory sensitivities in fruit flies
7. Evolution follows few of the possible paths to antibiotic resistance
8. Evolution mystery: Spider venom and bacteria share same toxin
9. Evolution of irreducible complexity explained
10. Evolutionary scrap-heap challenge: Antifreeze fish make sense out of junk DNA
11. Evolutionary forces explain why women live longer than men
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2017)... The global military biometrics market ... by the presence of several large global players. The ... major players - 3M Cogent, NEC Corporation, M2SYS Technology, ... 61% of the global military biometric market in 2016. ... military biometrics market boast global presence, which has catapulted ...
(Date:4/11/2017)... BEACH GARDENS, Fla. , April 11, 2017 ... identity management and secure authentication solutions, today announced ... contract by Intelligence Advanced Research Projects Activity (IARPA) ... for IARPA,s Thor program. "Innovation has ... onset and IARPA,s Thor program will allow us ...
(Date:4/5/2017)...  The Allen Institute for Cell Science today announces ... portal and dynamic digital window into the human cell. ... application of deep learning to create predictive models of ... a growing suite of powerful tools. The Allen Cell ... publicly available resources created and shared by the Allen ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... ... April 27, 2017 , ... ... Borlaug CAST Communication Award goes to Jayson Lusk, a consummate communicator who promotes ... media to advocate for science, as he explains how innovation and growth in ...
(Date:4/26/2017)... SAN DIEGO, CALIF. (PRWEB) , ... April 26, ... ... Mother’s Day? Lajollacooks4u, San Diego’s premiere team-building and cooking events company, offers ... cooking classes. , Menus specialize in California cuisine, and guests leave inspired ...
(Date:4/26/2017)... ... April 25, 2017 , ... LABS, Inc. (LABS) announced in December 2016 ... extensive test menu: Nucleic Acid Testing (NAT) for ZIKV; and Enzyme Immunoassays (EIAs) specific ... offer NAT screening for blood donors under an Investigational New Drug (IND) study protocol. ...
(Date:4/26/2017)... Va. (PRWEB) , ... April 26, 2017 , ... ... make headlines and drive high-level conversations among healthcare industry stakeholders, the discussion surrounding ... Environment – taking place May 15-18, 2017 in Los Angeles, Calif. Hosted by ...
Breaking Biology Technology: