( t camp. As soon as you have interac...)Ernst Mayr's theory illustrated in genetic epidemiology studies

"As soon as you have interactions between genes and then change the frequencies of these genes through some random factor, you're going to have a tremendous shift in where natural selection is directed in a genetic sense," he said. "This is the underlying basis of genetic revolution. We have documented that a gene major in one population is minor in another. This is a very real phenomenon that documents Mayr's point of view."

Templeton said that the Fisher camp views major and minor genes as if they are the properties of the single gene itself. His, Wright's and Mayr's view is that major and minor are properties of an interactive genetic system, and, depending on the frequencies of the interacting factors, some genes seem to play a larger role than others at any given time.

"The real causation of the trait is at the interaction level and not the single gene level, and therefore if you change just the frequency of the gene you'll change what's major and what's minor, and that's another way of saying you're changing how natural selection acts on the system," he said.