Navigation Links
Enzyme allows B cells to resist death, leading to leukemia

B cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia in adults and is characterized by the progressive accumulation of mature B lymphocytes in the blood, bone marrow, and lymphatic tissues. It is believed that in the early stages of disease, B-CLL is the result of an undefined defect in the programmed signals that trigger normal B cell death (apoptosis). Livio Trentin and colleagues from Padua University School of Medicine now demonstrate that high levels of expression and altered cellular location of an enzyme in B cells known as Lyn, contributes to the development of B-CLL.

The authors examined leukemia cells from 40 patients with B-CLL and compared them with lymphocytes from normal donors. They found that Lyn was markedly overexpressed in CLL cells and an unusual amount of the enzyme was found in the cell cytosol. In addition, the enzyme was constantly active compared with levels of activity in normal donor cells. The authors went on to show that inhibition of Lyn was able to restore the process of cell apoptosis to normal and treatment of malignant cells with drugs that induce cell death decreased both Lyn expression levels and activity ?suggesting a direct correlation between high Lyn activity and the ability of these B cells to resist apoptosis. The authors suggest that Lyn is involved in the development of B-CLL and that this enzyme therefore represents an attractive target for therapy. The study will appear online on January 13 in advance of publication in the February 1 print edition of the Journal of Clinical Investigation.
'"/>

Source:Journal of Clinical Investigation


Page: 1

Related biology news :

1. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
2. Novel Enzyme Shows Potential As An Anti-HIV Target
3. Enzyme shown to help protect genomic stability
4. Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol
5. Enzymes newly discovered role may make it target for arthritis treatment
6. Promiscuous Catalytic Activity Possessed by Novel Enzyme Structure
7. Gene Bridges And Covalys To Develop Restriction-Enzyme-Free SNAP-tag Gene Fusion Kits
8. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
9. Enzyme affects hypertension by controlling salt levels in body
10. Enzyme inhibitors block replication of SARS virus
11. Enzyme crystal structure reveals unexpected genome repair functions
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Enzyme allows cells resist death leading leukemia

(Date:8/21/2014)... intake, health and quality of life of older adults ... the University of Waterloo receiving close to $1.5 million ... (CIHR). , Professor Heather Keller, of the Faculty ... research chair in nutrition and aging, will receive $979,000 ... in long-term care homes are poorly nourished. The project ...
(Date:8/21/2014)... In a finding that has implications for life ... elsewhere in the solar system, LSU Associate Professor of ... the National Science Foundation, or NSF, this week published ... a lake that lies 800 meters (2600 feet) beneath ... "viable microbial ecosystems.", Given that more than 400 subglacial ...
(Date:8/21/2014)... water window? It consists of radiations in the 3.3 ... the water in biological tissues. New theoretical findings show ... the water window. These could be the basis of ... the biological samples or to be used in high-precision ... mechanism needed to efficiently generate the harmonic radiationswhich are ...
Breaking Biology News(10 mins):Grants will fund landmark aging research at Waterloo 2800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 2800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 3800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 4Water window imaging opportunity 2
... in French . , Montreal, December 11, ... that prevents cancer. In the December 11 edition of the ... de Montral and the Universit de Sherbrooke explain how they ... cytokines, hormones that are culprits in cancer-prone chronic inflammation diseases ...
... Arno Motulsky, the senior editor of the 4th edition ... Human Genetics, was recently given the Victor A. McKusick ... contributions to the field of human genetics, was presented ... American Society of Human Genetics on 24 October 2009 ...
... ORFruit growers, profits have traditionally been limited by ... seasons can be short. Thanks to researchers and ... that offer growers the ability to produce fruit ... producers and consumers. Fresh examples are the new ...
Cached Biology News:Scientists identify natural anti-cancer defenses 2New management methods extend blackberry season 2
(Date:8/21/2014)... 21, 2014  BioSpecifics Technologies Corp. (NASDAQ: ... in class collagenase-based products marketed as XIAFLEX ® ... U.S. and XIAPEX ® in the EU, ... randomized, double-blind Phase 2a study of CCH for ... panniculopathy. The results showed that all three doses ...
(Date:8/21/2014)... observed tiny quantum vortices in cold droplets of liquid ... that the exotic vortices arrange themselves as densely ... time that the quantum vortices, which have already been ... superfluid helium, have been detected in nanodroplets. "The experiment ... the University of Southern California, one of the experiment,s ...
(Date:8/21/2014)... 21, 2014 His Majesty Willem-Alexander, King ... The Court of His Majesty Willem-Alexander, King of the ... Grand Opening of POET-DSM Advanced Biofuels’ Project LIBERTY cellulosic ... , The King will take part in the Grand ... for 11 a.m.-12:20 p.m. and tour the plant. POET-DSM ...
(Date:8/21/2014)... , Aug. 21, 2014  Decision Resources Group ... Brazil and Mexico ... of several newly approved agents, the anticipated label ... and the launch of emerging biologics will substantially ... particular, the emerging IL-5 inhibitors will introduce a ...
Breaking Biology Technology:BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5Scientists observe quantum vortices in cold helium droplets 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3
... , , ... July 14 Accera, Inc., a biotechnology company delivering ... further evidence for genetic interactions impacting the efficacy of ... New data from the company,s previously completed double-blind, placebo-controlled ...
... ... ... July 14, 2009 -- Quantros, a leading provider of safety and quality software and ... Hospital and USC Kenneth Norris, Jr. Cancer Hospital at the University of Southern California. ...
... ... developed by Dr. Charles Stewart at DualAlign LLC is breaking new ground in medical ... and stitch images even if the originals were taken from different cameras, of varying ... , ...
Cached Biology Technology:Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimer's Disease 2Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimer's Disease 3Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimer's Disease 4USC Hospitals Extend Relationship With Quantros to Manage Compliance and Risk 2USC Hospitals Extend Relationship With Quantros to Manage Compliance and Risk 3Powerful Image Registration and Recognition Software Unveiled for Medical, Satellite, and Defense Imaging Industries 2Powerful Image Registration and Recognition Software Unveiled for Medical, Satellite, and Defense Imaging Industries 3
HybriWell seals securely to a microscope slide surface in seconds to enclose single or multiple specimens in a small reagent volume and eliminate evaporation....
... mm depth • Reusable, press-to-seal gasket and ... assembled and disassembled for hybridizing and imaging ... thickness with up to a 13 mm ... slide. Minimize specimen handling, eliminate evaporation and ...
... polystyrene formulation , High antibody-binding surface improves ... , Plates are certified for performance ... , Eight-well strips fit snugly in the plate ... even if turned upside down ...
12 breakable polypropylene strips of 8 wells each held in a rigid frame. Ideal for antibody assays....
Biology Products: