Navigation Links
Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer

In a finding that broadens our insight into the cause of certain kinds of UV-induced skin cancer, researchers at Erasmus University Medical Center (Rotterdam, The Netherlands) have employed an evolutionarily ancient enzyme-repair system to identify the principal type of DNA damage responsible for the onset of skin-tumor development. The researchers' findings also suggest that this enzyme system may be useful in developing preventative therapies against skin cancer.

Ultraviolet light is a known source of damage to our DNA, but under normal conditions humans and other mammals are capable of removing UV-induced DNA damage by a DNA repair mechanism called nucleotide excision repair. Insufficient repair of UV-induced DNA damage, which for example may occur after excessive unprotected sunbathing, can lead to cellular death ?recognized as sunburn of the skin ?and may cause permanent changes in the DNA (mutations) that ultimately can result in the onset of skin cancer. Thus far it was not clear how the two major types of UV-induced DNA lesions ?cyclobutane pyrimidine dimers (CPDs) and (6-4)photoproducts (6-4PPs) ?contribute to the processes of cell death and cancer formation. Identifying the relative contributions of the two types of damage to tumor formation is critical for the development of therapies that could help prevent skin cancer. Moreover, CPDs and 6-4PPs have particular potential to cause lasting damage to mammalian cells because photolyases ?a class of enzymes capable of efficiently repairing these lesions ?have apparently been lost from placental mammals over the course of evolution. Thus, most mammals, including humans, can only repair these lesions through a much less direct and elaborate process called nucleotide excision repair. In the new work, Dr. Bert van der Horst and colleagues studied the effects of CPD and 6-4PP lesions by providing mice with transgenes encoding CPD and 6-4PP photolyase enzymes. Although mice do not ordinarily produce these en
'"/>

Source:Eurekalert


Page: 1 2

Related biology news :

1. Unlike other mammals, newborn dolphins and orcas stay active 24/7 during first months of development
2. More evidence mammals, fruit flies share make-up on function of biological clocks
3. Dinosaur extinction didnt cause the rise of present-day mammals, claim researchers
4. Topical treatment shown to inhibit HIV and herpes simplex virus infection
5. Controversial drug shown to act on brain protein to cut alcohol use
6. Enzyme shown to help protect genomic stability
7. Novel gene-silencing nanoparticles shown to inhibit Ewings sarcoma
8. New imaging technology shown to detect pancreatic inflammation in type 1 diabetes
9. First direct mechanical communication of mitochondria, cardiomyocyte nucleus shown
10. Ultra low-dose estrogen shown safe for post-menopausal women
11. Vaccine shown effective against chancroid
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Enzyme lost most mammals shown protect against induced skin cancer

(Date:9/19/2014)... unveiled today by researchers from several Harvard University ... both experienced and aspiring researchers with the intellectual ... robots made from soft, flexible materials. , With ... and other advances in manufacturing technology, soft robotics ... principles drawn from conventional rigid robot design, but ...
(Date:9/19/2014)... sense of fairness did not evolve for the sake ... the benefits of continued cooperation, so say Frans de ... review article about inequity aversion (IA), which is defined ... is published in Science . , Their ... IA-related studies to address their hypothesis that it is ...
(Date:9/19/2014)... new study shows that legume plants regulate their ... molecules that are transmitted through the plant structure ... number of bacteria-holding nodules in the roots. This ... National Institute for Basic Biology, the Graduate University ... for Sustainable Resource Science in Japan. , ...
Breaking Biology News(10 mins):Soft robotics 'toolkit' features everything a robot-maker needs 2Evolution of responses to (un)fairness 2Evolution of responses to (un)fairness 3For legume plants, a new route from shoot to root 2
... painted with gold purify the air when they are ... of Technology experts have discovered. Associate Professor Zhu ... Sciences said that glaziers in medieval forges were the ... different sizes. Professor Zhu said numerous church ...
... detailed images of the body,s anatomy. Thanks to novel ... scientist Eric Ahrens, MRI can be used to visualize ... in the living body. The ability to non-invasively locate ... aid the study and treatment of cancer, inflammation, and ...
... August 20, 2008 New phase 2 data published ... investigational oral drug PTC124 demonstrates activity in nonsense-mutation cystic ... PTC124 results in statistically significant improvements in the chloride ... study was conducted at the Hadassah Hebrew University Hospital ...
Cached Biology News:Air-purifying church windows early nanotechnology 2Carnegie Mellon MRI technology that non-invasively locates, quantifies specific cells in the body 2Carnegie Mellon MRI technology that non-invasively locates, quantifies specific cells in the body 3PTC124 shows activity in cystic fibrosis; Phase 2 proof-of-concept data published in Lancet 2PTC124 shows activity in cystic fibrosis; Phase 2 proof-of-concept data published in Lancet 3
(Date:9/19/2014)... Charlotte, NC (PRWEB) September 19, 2014 ... Certified Biobased Product Label for its Organic Cotton ... the product’s amount of renewable biobased ingredients meets or ... or intermediate materials composed in whole or in significant ... “This logo/label will allow our Organic cotton to be ...
(Date:9/19/2014)... , September 19, 2014 , ... European Society for Paediatric Endocrinology (ESPE) Meeting  ... and medical research in the field of growth  , ... Darmstadt, Germany , today announced the ... for 2014. The awards were announced during a Satellite ...
(Date:9/18/2014)... HealthTronics, Inc ., a ... products and services, announced that a poster related ... versus external beam radiotherapy (EBRT) is being presented ... Association (MAAUA) Annual Meeting in Baltimore, Maryland September ... Cryosurgery and External Beam Radiation as Treatments for ...
(Date:9/18/2014)... 18, 2014 A novel robotic system ... scanner is currently being tested as part of a ... in Boston with the aim of determining if the ... prostate cancer biopsies faster, more accurate, less costly, and ... has the potential to deliver prostate cancer therapies with ...
Breaking Biology Technology:Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 3HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6
... Sweden has shown that biosynthetic corneas can help regenerate and ... results, from an early phase clinical trial with 10 patients, ... Science Translational Medicine . "This study is important because ... cornea can integrate with the human eye and stimulate regeneration," ...
... Enterprise Institute (Mtech) Bioprocess Scale-Up Facility (BSF) will double ... equipment, and create a pilot plant for biofuels in College ... from the Maryland Biotechnology Center . "The ... make sure the BSF,s capabilities are available to the growing ...
... bioserie is first to market with a line ... device owners the protection they demand while using only ... use of the latest in bioplastics technology offers considerably ... of environmental toxic pollution once the cover is discarded. ...
Cached Biology Technology:Seeing the world with new eyes: Biosynthetic corneas restore vision in humans 2Mtech Bioprocess Scale-Up Facility to Double in Staff and Size, Expand to Shady Grove, Create Pilot Plant for Biofuels in College Park 2Mtech Bioprocess Scale-Up Facility to Double in Staff and Size, Expand to Shady Grove, Create Pilot Plant for Biofuels in College Park 3bioserie Introduces the World's First 'Made of Plants' iPhone 4 Cover 2
... fluorescent and highly photostable FluoSpheres microspheres ... a variety of applications requiring probes ... Unfortunately, protein- and other macromolecule-labeled microspheres ... them to bind to non-target surfaces ...
Goat polyclonal to Duffy / FY / DARC...
SMVT (N-14)...
... Description: Proteinase K is a highly ... range of applications purified from the fungus T. ... carboxyl group of N-substituted hydrophobic aliphatic and aromatic ... a serine protease. Proteinase K is useful in ...
Biology Products: