Navigation Links
Environmental toxins may cause body's defenses to worsen lung disease

he cell receives a signal that the tissue is infected, it will automatically destroy it to protect the body from disease.

"The immune system thinks it's eradicating disease from the body when it destroys cells that have been damaged by environmental toxins, but in chronic lung disease that destruction may be doing more harm than good," he says.

Chronic pulmonary diseases cause irreversible damage and inflammation in the lungs that lead to scarring and narrowing of the airways. The most common of these diseases are obstructive pulmonary disease, chronic bronchitis and emphysema. When a large amount of tissue is destroyed, Borchers says, it can cause irreparable damage to the elasticity of the lung and lead to additional health problems.

Using an animal model, Borchers will expose surface cells in the lung to two environmental toxins--the bacteria pseudomonas aeruginosa, a major cause of in-hospital infections, and acrolein, an air pollutant found in tobacco smoke, smog and diesel exhaust--to determine how cells respond to infection and toxicant-induced cell damage.

"By looking at how the cells react to these stimuli, we hope to gain insight into what triggers and mediates the immune system response," Borchers says.

This will help scientists determine which lymphocytes are important for regulating damage in the lungs, so they can develop ways to "tweak" the immune system and prevent the lymphocytes from causing additional damage to already-injured tissue.

Borchers says understanding these pathways could play an important role in future drug treatments for patients with chronic obstructive pulmonary disease and the basic scientific findings may also have applications in asthma and cystic fibrosis as well as other chronic lung diseases.

The overall goal of the study is to expand existing scientific knowledge of how epithelial cells in the lungs communicate with the immune system in response to environmental an
'"/>

Source:University of Cincinnati


Page: 1 2 3

Related biology news :

1. Environmental chemical cocktail may sabotage sperm
2. Environmental lessons from tsunami as worlds coastal population doubles
3. Environmental tobacco smoke linked to behavior problems in children and pre-teens
4. Environmental metagenomics diagnosing extreme environments, tapping opportunities for clean energy
5. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
6. Structures of marine toxins provide insight into their effectiveness as cancer drugs
7. UCSD study finds anthrax toxins also harmful to fruit flies
8. Yale researchers find environmental toxins disruptive to hearing in mammals
9. A new understanding of how cells defend themselves against bacterial pore-forming toxins
10. Dysentery uses sword and shield to cause infection
11. Scientists detect probable genetic cause of some Parkinsons disease cases
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Environmental toxins may cause body defenses worsen lung disease

(Date:8/20/2014)... Washington , August 20, 2014 ... Concerns in the Payment Industry?   Investorideas.com ... including biometrics, issues commentary from analysts and experts on the ... Managing Partner at Thrive Analytics, Isabelle Moeller of ... NXT-ID, Inc. (OTCBB: NXTD) ( OTCQB:NXTD ), a biometric company ...
(Date:8/19/2014)... systems be used in supermarkets to encourage healthier spending ... to answer that very question by tracking the purchasing ... Stars System to rate the nutritional value of foods ... Brand Lab,s David Just, PhD, and Brian Wansink PhD, ... records of over 150 Hannaford Supermarkets in the Northeastern ...
(Date:8/19/2014)... parts of the world, leprosy and tuberculosis live ... of leprosy per year, with nearly all of ... available century-old vaccine Bacille Calmette-Guerin, or BCG, provides ... so a more potent vaccine is needed to ... a stronger weapon against both diseases., In a ...
Breaking Biology News(10 mins):Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 2Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 3Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 4Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 5Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 6Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 7New vaccine shows promise as stronger weapon against both tuberculosis and leprosy 2
... 3 HIV vaccine efficacy trial are reported in the March ... online. Although the vaccine was ineffective in preventing HIV infection, ... and offers the scientific community a foundation on which to ... United States and the Netherlands and completed in 2003, is ...
... evidence in laboratory studies that the immune system may ... the drug through an unusual vaccine-like mechanism. Their finding, ... chronic users go on long binges with the illicit ... to new treatments for the drug's addiction, they say. ...
... access publishing and the NIH new policy from ... of Health (NIH) rule on Enhanced Public Access to ... and a missed opportunity to take advantage of available ... the nation's leading not-for-profit medical and scientific publishers. The ...
Cached Biology News:HIV vaccine trial breaks ground for future research 2Chemists identify immune system mechanism for methamphetamine binges 2Chemists identify immune system mechanism for methamphetamine binges 3Not-for-profit publishers call NIH public access rule a missed opportunity 2Not-for-profit publishers call NIH public access rule a missed opportunity 3
(Date:8/18/2014)... 2014 Deep Research Report on ... and in-depth research report on the China Linalool ... including its definition, classification, application, and industry chain ... covers the international market analysis, including China’s domestic ... macroeconomic environment & economic situation analysis. The report ...
(Date:8/18/2014)... Aug. 18, 2014 BioElectronics Corporation ... consumer medical devices said that its EVP ... by CEOLIVE.TV as part of its Executive ... is available at http://ceolive.tv/bioelectronics-corp-otc-biel/biel-videos/2282-ceolive-tv-interview-bioelectronics-corp-otcqb-biel ... to investors the unique advantages of BioElectronics ...
(Date:8/18/2014)... Global HIV Infection Drug Market and Pipeline Insight ... of HIV infection and the number of deaths due to ... rate across the globe. It has been estimated that the ... in 2013, with the rates for children being even much ... infection rates has been the improved access to antiretroviral drugs ...
(Date:8/18/2014)... , Aug. 18, 2014 TNI BioTech, Inc. ... pioneering the manufacturing and marketing of innovative therapies for ... Company is providing a second notice of TNI BioTech,s ... making the announcement, Noreen Griffin , founder and ... advance for your participation in the Annual Meeting. On ...
Breaking Biology Technology:Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 2Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 3Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 4BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 2BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 3Global HIV Infection Drug Market Overview 2Global HIV Infection Drug Market Overview 3Global HIV Infection Drug Market Overview 4TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 2TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 3TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 4
... from the nations nuclear weapons program lie in a ... Beneath this desert landscape about two million curies of ... are captured within the stratified vadose zone below which ... paths create uncertainties about where the contaminants go and ...
... - Researchers have developed a new modeling technique ... that could help industry perfect lab-on-a-chip technology for ... , The experimental devices represent a new class ... specific "target molecules," which will allow the sensors ...
... PAUL, Minn., Jan. 3 /Xinhua-PRNewswire/ --,WuXi PharmaTech ... of pharmaceutical R&D,outsourcing services, has signed a ... Inc. (AppTec). The acquisition of AppTec allows,WuXi ... expertise,gain a significant U.S. operational footprint, and ...
Cached Biology Technology:Where does stored nuclear waste go? 2Model is first to compare performance of 'biosensors' 2Model is first to compare performance of 'biosensors' 3WuXi PharmaTech to Acquire AppTec Laboratory Services, Inc. 2WuXi PharmaTech to Acquire AppTec Laboratory Services, Inc. 3WuXi PharmaTech to Acquire AppTec Laboratory Services, Inc. 4WuXi PharmaTech to Acquire AppTec Laboratory Services, Inc. 5
... Tracker Intracellular Localization Kit provides a straight ... siRNA, of your design, in an efficient ... experiments. Subcellular localization and functional inhibition of ... introduction of the labeled siRNA into mammalian ...
Ideal for chemical processing that requires downward flow of exhaust fumes. Powderful 1200 CFM blower draws fumes into sub-surface bonded charcoal filter for safe removal of organic vapors (final HEP...
... siRNA Tracker Intracellular Localization Kit with ... forward approach to directly label and ... an efficient yet non-destructive manner, for ... and functional inhibition of target gene ...
... IT siRNA Tracker Intracellular Localization Kit provides ... and deliver siRNA, of your design, in ... vitro tracking experiments. Subcellular localization and functional ... monitored following introduction of the labeled siRNA ...
Biology Products: