Navigation Links
Environmental chemical cocktail may sabotage sperm

m to undergo an acrosome reaction. This is when the cap on the head of the sperm ruptures and releases enzymes that enable the sperm to penetrate the coverings of the egg. If the acrosome reaction happens before a sperm reaches the egg, then fertilisation is unable to take place because the sperm has lost special "docking" molecules that allow it to bind to the egg.

Prof Fraser said: "Human sperm proved to be even more responsive than mouse sperm to genistein. These compounds are classified as environmental oestrogens, but they are very weak, so normally you would expect them to have to be in concentrations around 1,000 times stronger to get a response similar to that prompted by the naturally occurring oestrogen, oestradiol. Yet human sperm are responding to very low concentrations ?well within the amounts that have been measured in people's blood.

"At a time when there are concerns that the incidence of infertility may be rising, this research flags up important warning signs. Very little is currently known about the control of sperm function, especially in the body rather than in the laboratory, but the sensitivity of human sperm to these chemicals means that further investigations should be carried out to determine whether such environmental compounds might contribute to a decrease in human fertility. Other scientists have investigated the negative impact of environmental chemicals on testis function, resulting in reduced numbers of sperm being produced, but these effects require much larger doses than we have used. As far as I am aware, we are the only group looking at subtle effects that could have a serious impact on fertility without reducing the number of sperm being produced."

The mechanism of action of the environmental oestrogens was still not clear, but the researchers discovered that both genistein and nonylphenol significantly stimulated the production of cyclic AMP ?a chemical messenger, produced within the cell after external
'"/>

Source:European Society for Human Reproduction and Embryology


Page: 1 2 3

Related biology news :

1. Environmental lessons from tsunami as worlds coastal population doubles
2. Environmental tobacco smoke linked to behavior problems in children and pre-teens
3. Environmental metagenomics diagnosing extreme environments, tapping opportunities for clean energy
4. Environmental toxins may cause bodys defenses to worsen lung disease
5. BRCA1 causes ovarian cancer through indirect, biochemical route
6. Study shows nanoshells ideal as chemical nanosensors
7. MSI releases moleculizer - a new approach to simulation of intracellular biochemical networks
8. Researchers discover chemical compounds that affect plant growth
9. Harmful chemicals may reprogram gene response to estrogen
10. Disease diagnosis, biodefense among UH chemical research projects
11. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Environmental chemical cocktail may sabotage sperm

(Date:9/18/2014)... cheerful, happy-go-lucky characters, so you might expect that most ... In fact some dogs are distinctly more pessimistic than ... , "This research is exciting because it measures positive ... It offers researchers and dog owners an insight into ... Dr Melissa Starling, from the Faculty of Veterinary Science. ...
(Date:9/18/2014)... 18, 2014 Elsevier, a world-leading provider of ... and the Australasian Research Management Society (ARMS), recognized ... at the 5th Scopus Young Researcher of the ... today at the National Convention Centre and in ... attended by guests representing Australia,s and New Zealand,s ...
(Date:9/18/2014)... swim up to 400 kilometres in search of a home, ... , Clownfish spend their entire adult lives under the protection ... the open ocean, says study co-author, Dr Hugo Harrison from ... CoE) at James Cook University. , "In the past we ... a rare glimpse into how far they can swim, crossing ...
Breaking Biology News(10 mins):Dogs can be pessimists too 2Dogs can be pessimists too 3Elsevier and Australasian Research Management Society award scientists at Scopus ceremony 2Nemo's epic journey to find a new home 2
... RESTON, Virginia, February 10 WCC Smart Search ... match software, today,announced its participation as a subcontractor ... - Unrestricted (BOSS-U) program. , ... will compete for,task orders with an overall ceiling ...
... The National Science Foundation has awarded a five-year, ... and two other universities to fund a research ... new technologies include improved monitoring of large-scale water ... of detecting dangerous chemical or biological contaminants. ...
... squeezing the middle class on land, it,s also affecting ... Conservation Society (WCS) and other organizations, researchers discovered a ... and low fish levels. Curiously, areas with both ... levels. Appearing in the latest edition of ...
Cached Biology News:WCC Smart Search & Match to Support U.S. Army's BOSS-U Program 2NSF to fund water and environment technology center 2Study says 'middle class' coral reef fish feel the economic squeeze 2
(Date:9/18/2014)...  Health Enhancement Products, Inc. (OTCQB: HEPI), a ... and metabolic processes, is pleased to announce the addition of ... Nola E. Masterson , a California ... September 17, 2014. "We,re very pleased and ... states Andrew Dahl , President and CEO. "She joins ...
(Date:9/18/2014)... Washington, D.C. (PRWEB) September 18, 2014 ... Dick Durbin and Sen. Jim Risch for National Lab ... research projects from across the national laboratory system. Durbin ... Caucus, which aims to increase awareness of the reach ... breakthrough technologies and discoveries to address some of our ...
(Date:9/18/2014)... DUBLIN , Sept. 18, 2014 ... the "Global Human Albumin Industry Report 2014" ... Human Albumin Industry Report 2014 is a professional and ... human albumin industry. The report provides a ... and industry chain structure. The human albumin market analysis ...
(Date:9/18/2014)...  U.S. biotech company Kultevat has strengthened ... technology developed by the Donald Danforth Plant Science ... for applications in production of natural rubber in ... developed under the direction of Roger Beachy , ... of the Danforth Plant Science Center, and is used ...
Breaking Biology Technology:Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Kultevat obtains license of gene switch technology 2
... second time this year, a tech-based company in Wisconsin has ... public. Called an initial public offering, this kind of business ... who are directly involved, but to others who may follow ... company, has filed papers with the Securities and Exchange ...
... Madison, Wis. - Alfalight , a manufacturer ... and development contract worth $1.7 million from the ... Alfalight will develop pump modules suitable for pumping high-power, ... for defense applications and new commercial products. , ,Manoj ...
... athlete only three years ago, but his Milwaukee-based mobile software ... opening in 1996. , ,And now, the route of ... Asia. , ,Psuik, founder and owner of Developer ... with O2 , a European mobile phone provider, to ...
Cached Biology Technology:Wisconsin IPOs are a harbinger of growing tech economy 2Wisconsin IPOs are a harbinger of growing tech economy 3Milwaukee software developer gains bottom line, loses waistline 2Milwaukee software developer gains bottom line, loses waistline 3Milwaukee software developer gains bottom line, loses waistline 4
Mouse monoclonal antibody raised against a full length recombinant GPT. NCBI Entrez Gene ID = GPT...
Mouse monoclonal antibody raised against a partial recombinant PDE2A. NCBI Entrez Gene ID = PDE2A...
... The E. coli protein sample ... to give a consistent pattern when ... rehydration and sample buffer. This sample ... to validate your 2-D system and ...
... Tecans new HydroFlex platform provides ... a range of 96-well format applications, ... and protein arrays, and vacuum filtration-to-waste, ... platforms outstanding on-line control features set ...
Biology Products: