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Enlisting genomics to understand flu evolution

tudy shows that persistently cocirculating minor strains--which might be accumulating mutations with little obvious epidemiological consequences--can suddenly cause an epidemic with just one or two more mutations.

These results suggest that "the potential diversity is greater than we thought," says Lipman. "We need to have more comprehensive information on the entire genome [and] enough samples from around the world," he adds, to find the benign virus strain that will become next season's scourge. The more genomes scientists collect--and the more refined the tools of genomics become--the greater the chances of developing more effective vaccines.

Citation: Holmes EC, Ghedin E, Miller N, Taylor J, Bao Y, et al. (2005) Whole-genome analysis of human influenza A virus reveals multiple persistent lineages and reassortment among recent H3N2 viruses. PLoS Biol 3(9): e300.


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Source:Public Library of Science


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