Navigation Links
Enlisting genomics to understand flu evolution

Multiple strains of the flu virus, circulating in a population at the same time, can reshuffle their genes and create a new virus, one capable of infecting many more people, according to a new study in the open-access journal PLoS Biology. This finding may help scientists make better predictions about which viral strains will attack during upcoming flu seasons and design more effective flu vaccines.

In the first large-scale effort to sequence the flu genome, Edward Holmes, David Lipman, and colleagues examined the genomes of 156 influenza A viruses (serotype H3N2) collected by New York State public health officials between 1999 and 2004. "We found that there are co-circulating minor variants that are not infecting many people," says Lipman. "One of these can become the next epidemic strain."

These co-circulating viruses can exchange genes in a way that creates novel, epidemiologically significant strains--a process that can occur when someone is infected simultaneously by more than one strain. The genetic reshuffling demonstrated in this study is the first to examine in detail a reassortment event from a persistently cocirculating minor strain to a previously dominant strain leading to an epidemiologically significant outcome--the emergence of the "Fujian" strain in the 2003-2004 flu season.

The Institute for Genomic Research, with funding from the National Institute for Allergy and Infectious Diseases, sequenced the genomes of the collected flu viruses. Examining these sequences, Holmes et al. found that a relatively uncommon strain of virus contributed its hemagglutinin gene (a highly variable viral protein that must be recognized by the host's immune defense system) to a virus common during the previous year. The reassorted virus suddenly became capable of infecting thousands. "The key thing here is that the general notion of epidemic flu is that there's a series of successions by variants of the flu we got the previous year." But the new s tudy shows that persistently cocirculating minor strains--which might be accumulating mutations with little obvious epidemiological consequences--can suddenly cause an epidemic with just one or two more mutations.

These results suggest that "the potential diversity is greater than we thought," says Lipman. "We need to have more comprehensive information on the entire genome [and] enough samples from around the world," he adds, to find the benign virus strain that will become next season's scourge. The more genomes scientists collect--and the more refined the tools of genomics become--the greater the chances of developing more effective vaccines.

Citation: Holmes EC, Ghedin E, Miller N, Taylor J, Bao Y, et al. (2005) Whole-genome analysis of human influenza A virus reveals multiple persistent lineages and reassortment among recent H3N2 viruses. PLoS Biol 3(9): e300.


'"/>

Source:Public Library of Science


Related biology news :

1. New comparative toxicogenomics database
2. Measuring the impact of post-genomics on Mediterranean populations
3. Owl genomics presents a HEPATOCHIP for diagnosis of non-alcoholic steatohepatitis
4. Drawing with DNA: Bioart illuminates genomics
5. Study reveals genomics of inflammation from severe injury
6. NIH launches comprehensive effort to explore cancer genomics
7. Environmental metagenomics diagnosing extreme environments, tapping opportunities for clean energy
8. Ticks, flukes, and genomics: Emerging pathogens revealed
9. UC San Diego partners with Venter Institute to build marine microbial genomics cyberinfrastructure
10. Advanced genomics and proteomics improve the diagnosis and treatment of a deadly lung disease
11. Large-scale genomics project will hunt genes behind common childhood diseases
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/20/2017)... 20, 2017 At this year,s CeBIT Chancellor Dr. ... manufacturer DERMALOG. The Chancellor came to the DERMALOG stand together with the ... year,s CeBIT partner country. At the largest German biometrics company the two ... face and iris recognition as well as DERMALOG´s multi-biometrics system.   ... ...
(Date:3/16/2017)... CeBIT 2017 - Against identity fraud with DERMALOG solutions "Made in Germany ... ... in one project, multi-biometric solutions provide a crucial contribution against identity fraud. (PRNewsFoto/Dermalog Identification Systems) ... Used combined in one project, multi-biometric solutions provide a crucial ... ...
(Date:3/9/2017)... Australia , March 9, 2017 4Dx ... prestigious World Lung Imaging Workshop at the University of ... was invited to deliver the latest data to world ... recognised event brings together leaders at the forefront of ... in lung imaging. "The quality of ...
Breaking Biology News(10 mins):
(Date:3/30/2017)... Personal Genome Diagnostics Inc. (PGDx) today announced that ... for Cancer Research (AACR) Annual Meeting 2017, being held April ... company also announced that five scientists associated with PGDx—two co-founders ... Annual AACR Team Science Award. ... Doug Ward , CEO of ...
(Date:3/29/2017)... Inc. (NASDAQ: VRML), a bio-analytical solutions company focused ... the fourth quarter and full year ended December ... year for us with our first clinical utility ... reimbursement progress with Medicare, positive medical policy coverage ... cleared our 2 nd generation product Overa ...
(Date:3/29/2017)... 2017 WuXi Biologics, a leading open-access ... biologics and a WuXi AppTec Affiliate, today announced ... Bioprocessing Excellence Award from IMAPAC, a leading consulting ... to recognize outstanding leaders and trend-setters of today, ... and biomanufacturing experts in the industry, along with ...
(Date:3/29/2017)... 29, 2017  Applied BioMath ( www.appliedbiomath.com ... to drug research and development, today announced ... Inc. for quantitative systems pharmacology (QSP) support ... the treatment of cancer. ... GLP toxicology studies and first-in-human dose predictions ...
Breaking Biology Technology: