Navigation Links
Enlisting genomics to understand flu evolution

Multiple strains of the flu virus, circulating in a population at the same time, can reshuffle their genes and create a new virus, one capable of infecting many more people, according to a new study in the open-access journal PLoS Biology. This finding may help scientists make better predictions about which viral strains will attack during upcoming flu seasons and design more effective flu vaccines.

In the first large-scale effort to sequence the flu genome, Edward Holmes, David Lipman, and colleagues examined the genomes of 156 influenza A viruses (serotype H3N2) collected by New York State public health officials between 1999 and 2004. "We found that there are co-circulating minor variants that are not infecting many people," says Lipman. "One of these can become the next epidemic strain."

These co-circulating viruses can exchange genes in a way that creates novel, epidemiologically significant strains--a process that can occur when someone is infected simultaneously by more than one strain. The genetic reshuffling demonstrated in this study is the first to examine in detail a reassortment event from a persistently cocirculating minor strain to a previously dominant strain leading to an epidemiologically significant outcome--the emergence of the "Fujian" strain in the 2003-2004 flu season.

The Institute for Genomic Research, with funding from the National Institute for Allergy and Infectious Diseases, sequenced the genomes of the collected flu viruses. Examining these sequences, Holmes et al. found that a relatively uncommon strain of virus contributed its hemagglutinin gene (a highly variable viral protein that must be recognized by the host's immune defense system) to a virus common during the previous year. The reassorted virus suddenly became capable of infecting thousands. "The key thing here is that the general notion of epidemic flu is that there's a series of successions by variants of the flu we got the previous year." But the new s
'"/>

Source:Public Library of Science


Page: 1 2

Related biology news :

1. New comparative toxicogenomics database
2. Measuring the impact of post-genomics on Mediterranean populations
3. Owl genomics presents a HEPATOCHIP for diagnosis of non-alcoholic steatohepatitis
4. Drawing with DNA: Bioart illuminates genomics
5. Study reveals genomics of inflammation from severe injury
6. NIH launches comprehensive effort to explore cancer genomics
7. Environmental metagenomics diagnosing extreme environments, tapping opportunities for clean energy
8. Ticks, flukes, and genomics: Emerging pathogens revealed
9. UC San Diego partners with Venter Institute to build marine microbial genomics cyberinfrastructure
10. Advanced genomics and proteomics improve the diagnosis and treatment of a deadly lung disease
11. Large-scale genomics project will hunt genes behind common childhood diseases
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Enlisting genomics understand flu evolution

(Date:12/17/2014)... -- Automation is fundamentally transforming the travel experience and ... borders. Over the past decade, ePassports, biometric readers, ... to self process through border control via eGates ... increasing number of airports, seaports, and land borders ... Maxine Most , Principal at Acuity Market ...
(Date:12/11/2014)... DUBLIN , Dec. 09, 2014 Research ... http://photos.prnewswire.com/prnh/20130307/600769 ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) ... Market in India 2015-2019" report to their ... in this market is the adoption of multimodal ... one characteristic of an individual for verification and ...
(Date:12/10/2014)... 2014 You,ve been here before: you desperately need ... your password, site key or the answer to your secret ... teacher? Today, Hoyos Labs , a ... will finally put an end to the frustration that comes ... . 1U leverages a user,s smartphone to acquire his or ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... Mutations that help HIV hide from the immune system undermine ... researchers in the April 13 issue of the Journal ... March 23. When HIV infects a cell, a ... leukocyte antigen) alert killer T cells by displaying bits of ...
... the latest American Chemical Society (ACS) Weekly PressPac from ... ACS, 34 peer-reviewed journals and Chemical & Engineering News.,Please ... as the source for this information. PressPac Archive: ... # 1 FOR IMMEDIATE RELEASE, Solving the mystery of ...
... BOSTON, Mass. (April 12, 2009) In certain respects, ... True, they have lots of components, but they also ... of people are studied in aggregate (conservatives, liberals, atheists, ... But when looked at one person at a time, ...
Cached Biology News:HIV pays a price for invisibility 2American Chemical Society Weekly PressPac -- April 8, 2009 2American Chemical Society Weekly PressPac -- April 8, 2009 3American Chemical Society Weekly PressPac -- April 8, 2009 4American Chemical Society Weekly PressPac -- April 8, 2009 5American Chemical Society Weekly PressPac -- April 8, 2009 6American Chemical Society Weekly PressPac -- April 8, 2009 7American Chemical Society Weekly PressPac -- April 8, 2009 8American Chemical Society Weekly PressPac -- April 8, 2009 9American Chemical Society Weekly PressPac -- April 8, 2009 10American Chemical Society Weekly PressPac -- April 8, 2009 11For cancer cells, genetics alone is poor indicator for drug response 2For cancer cells, genetics alone is poor indicator for drug response 3
(Date:12/22/2014)... December 22, 2014 Fertility Associates of ... Egg Bank USA , a network of more than ... this partnership, patients have fast access to a national ... fertilization, IVF . Fertility Associates of Memphis is the ... fertility treatment option. , Dr. William Kutteh , ...
(Date:12/19/2014)... Dec. 19, 2014  Roche (SIX: RO, ROG; OTCQX: ... Inc. (Bina), a privately held company based in ... Bina provides a big data platform for centralized ... data. Bina,s proprietary on-market Genomic Management Solution, Bina-GMS ... to perform fast and scalable analyses to maximize ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 Today, ... locate its pilot production facility and future company ... and produce innovative new materials that safely and ... not only because of its historic, strong support ... efforts to attract leading edge, technology-based companies such ...
(Date:12/19/2014)... 2014 In contrast to traditional LED ... various colors, Valoya uses proprietary LED technology to incorporate ... possible uniformity which is critical in low proximity installations. ... accuracy throughout its lifetime which is up to four ... , "The investment cost was clearly higher when compared ...
Breaking Biology Technology:Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 4
... Jan. 27, 2011 Warner Chilcott plc (Nasdaq: ... financial guidance prior to the market opening on Tuesday, February ... press release, the Company will host a conference call for ... AM (Eastern Time) to review the guidance. To participate in ...
... (GaN) and zinc oxide (ZnO) are among the ... ubiquitous today in optoelectronic elements such as blue ... zinc oxide also finds many uses in optoelectronics ... though, nanostructures made of these materials have shown ...
... Jan. 26, 2011 Sangamo BioSciences, Inc. (Nasdaq: ... fourth quarter and full year 2010 financial results on Wednesday, ... will be followed by a conference call at 5:00 p.m. ... and webcast. During the conference call, the company will review ...
Cached Biology Technology:Nanowires exhibit giant piezoelectricity 2Nanowires exhibit giant piezoelectricity 3Sangamo BioSciences Announces Fourth Quarter and Full Year 2010 Conference Call and Webcast 2
... direct, simple approach to covalently ... surface of an EIA plate ... its integrity and availability for ... room temperature conditions Open ...
... and clarification reagent; Ideal for clarifying ... antibodies, proteins, nucleic acids, & proteoglycans; ... and improves downstream processing; Utilizes a ... adsorbent supplied as a suspension in ...
AC input: 230 V...
... is designed to stabilize the biomolecules ... storage. There are neither animal ... is a convenient 10 times solution ... superior to other traditional lyophilizing additives ...
Biology Products: