Navigation Links
Enhancing activity of marijuana-like chemicals in brain helps treat

Marijuana-like chemicals in the brain may point to a treatment for the debilitating condition of Parkinson's disease. In a study to be published in the Feb. 8 issue of Nature, researchers from the Stanford University School of Medicine report that endocannabinoids, naturally occurring chemicals found in the brain that are similar to the active compounds in marijuana and hashish, helped trigger a dramatic improvement in mice with a condition similar to Parkinson's.

"This study points to a potentially new kind of therapy for Parkinson's disease," said senior author Robert Malenka, MD, PhD, the Nancy Friend Pritzker Professor in Psychiatry and Behavioral Sciences. "Of course, it is a long, long way to go before this will be tested in humans, but nonetheless, we have identified a new way of potentially manipulating the circuits that are malfunctioning in this disease."

Malenka and postdoctoral scholar Anatol Kreitzer, PhD, the study's lead author, combined a drug already used to treat Parkinson's disease with an experimental compound that can boost the level of endocannabinoids in the brain. When they used the combination in mice with a condition like Parkinson's, the mice went from being frozen in place to moving around freely in 15 minutes. "They were basically normal," Kreitzer said.

But Kreitzer and Malenka cautioned that their findings don't mean smoking marijuana could be therapeutic for Parkinson's disease.

"It turns out the receptors for cannabinoids are all over the brain, but they are not always activated by the naturally occurring endocannabinoids," said Malenka. The treatment used on the mice involves enhancing the activity of the chemicals where they occur naturally in the brain. "That is a really important difference, and it is why we think our manipulation of the chemicals is really different from smoking marijuana."

The researchers began their study by focusing on a region of the br
'"/>

Source:Stanford University Medical Center


Page: 1 2 3

Related biology news :

1. Exercise training in ordinary people affects the activity of 500 genes
2. New bioinformatics technique for systematically analyzing key regions in DNA that help control gene activity
3. Natural compound from pond scum shows potential activity against Alzheimers
4. Brain activity related to processing faces is similar in people with, without autism
5. Molecule by molecule, new assay shows real-time gene activity
6. Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers
7. Inflammation and drugs to control this activity studied in a variety of tumors sites
8. Hopkins researchers develop new tool to watch real-time chemical activity in cells
9. Structure determined for p53 tumor suppressor protein as bound to DNA for anti-cancer activity
10. Stem cell activity deciphered in the aging brain
11. Innovative movies show real-time immune-cell activity within tumors
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Enhancing activity marijuana like chemicals brain helps treat

(Date:8/19/2014)... analyzed concentrations of African dust transported to South ... spring. These research findings offer new insight on ... of African dust, including the climate change-induced human ... increased African dust emissions in the coming decades., ... School of Marine and Atmospheric Science and colleagues ...
(Date:8/19/2014)... release is available in German . ... new information about the metabolism of plants can switch ... Erich Kombrink from the Max Planck Institute for Plant ... University of Duisburg-Essen adopt a different approach. They identify ... process like brake pads and prevent the downstream reactions. ...
(Date:8/19/2014)... DIEGO, Calif. (August 19, 2014) Daylight was breaking ... MY Hanse Explorer. Between sips, about a dozen scientists ... and slip below the surface to collect water samples ... would tinker with the whirring gizmos and delicate machinery ... single goal: Be the first research group to bring ...
Breaking Biology News(10 mins):Study of African dust transport to South America reveals air quality impacts 2Researchers block plant hormone 2Researchers block plant hormone 3Sequencing at sea 2Sequencing at sea 3
... WORCESTER, Mass. A Worcester Polytechnic Institute (WPI) research ... the National Institutes of Health (NIH) to continue a ... to tools that will enable physicians to predict the ... heart attacks and strokes. Led by Dalin Tang, PhD, ...
... of bacteria can produce a lethal chemical that keeps ... the growth of nearby colonies and even killing some ... for themselves, even when the encroaching colony is closely ... is a superorganism, a multicellular organism with it,s own ...
... German . , In the coming decades, ... living conditions for plants, whereby major regional differences may be ... future provide habitats for additional species, and in arid and ... plant diversity will deteriorate. This is the conclusion reached in ...
Cached Biology News:WPI receives $1.4 million from NIH for pioneering work on arterial plaque and cardiovascular disease 2WPI receives $1.4 million from NIH for pioneering work on arterial plaque and cardiovascular disease 3Colonies of bacteria fight for resources with lethal protein 2Global warming threatens plant diversity 2Global warming threatens plant diversity 3
(Date:8/19/2014)... , Aug. 19, 2014 /PRNewswire/ - iCo Therapeutics Inc. ... today reported results of its Oral Amphotericin B ... reservoirs.  The study, conducted by ImmuneCarta®, the immune ... vitro effectiveness of Oral Amp B in ... in individuals despite intensive treatment with antiretroviral therapy. ...
(Date:8/18/2014)... FREDERICK, Md. , Aug. 18, 2014 ... the maker of advanced consumer medical devices ... Kotak was interviewed by CEOLIVE.TV as ... The entire interview is available at ... interview Dr. Kotak explains to investors the ...
(Date:8/18/2014)... According to the new ... (Municipal Wastewater Treatment and Industrial Wastewater Treatment), By ... By Configuration (Internal/Submerged and External/Sidestream), and By Region-Trends ... market for membrane bioreactor systems is projected to ... CAGR of 15.28% between 2014 and 2019. ...
(Date:8/16/2014)... NY (PRWEB) August 16, 2014 ... industry provide guidance and advisory services to ... and technical issues. Industry services are highly diverse ... Therefore, industry services range from geological and geophysical ... plans. “Consequently, over the past five years, the ...
Breaking Biology Technology:iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 3BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 2BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 3Membrane Bioreactor Systems Market Worth $2,927 Million by 2019 2Membrane Bioreactor Systems Market Worth $2,927 Million by 2019 3Scientific and Economic Consulting in Canada Industry Market Research Report Now Available from IBISWorld 2Scientific and Economic Consulting in Canada Industry Market Research Report Now Available from IBISWorld 3
... CPHD ) today announced that it will report financial results ... 30, 2009, after the close of the market. , , ... Time on Thursday, July 30, 2009, to discuss the results. ... www.cepheid.com/investors at least 15 minutes before the scheduled ...
... June 25, 2009 Veritide Ltd., a developer of ... new independent data to be presented at the Biodetection ... Ceeker (pronounced "seeker") portable bacterial detection device in discriminating ... data show that in over two weeks of testing ...
... N.J. Dr. Frank Fisher, an Assistant Professor of ... and Co-Director of the Graduate Nantoechnology Program at Stevens ... two 2009 Ferdinand P. Beer and E. Russell Johnston ... of Engineering Education (ASEE). , Fisher was selected on ...
Cached Biology Technology:Cepheid Schedules 2009 Second Quarter Financial Results Announcement and Webcast 2Novel handheld device detects anthrax with outstanding accuracy and reliability 2Novel handheld device detects anthrax with outstanding accuracy and reliability 3
...
... measures NOS activity by monitoring the conversion ... is simple, sensitive, and specific for NOS ... crude and purified enzyme preparations. The kit ... total reactions. Radiolabeled arginine and NADPH are ...
Human TSLP MAb (Clone 258136)...
Human Complement Component C5a MAb (Clone 295003)...
Biology Products: