Navigation Links
Engineering the heart piece by piece

“Although there remain tremendous technological challenges, we are now at a point where we can engineer first-generation prototypes of all cardiovascular structures: heart muscle, tri-leaflet valves, blood vessels, cell-based cardiac pumps and tissue engineered ventricles,?says Birla.

Research at the Artificial Heart Laboratory has focused on comparing different platforms to engineer functional heart muscle in the laboratory. Last December, Birla and first author Yen-Chih Huang, PhD, published a paper describing their success in growing pulsing, three-dimensional patches of bioengineered heart muscle, or BEHM. That paper describes the use of an innovative technique, using a fibrin hydrogel, that is faster than others, but still yields tissue with significantly better properties.

The gel was able to support rat cardiac cells temporarily, before the fibrin broke down as the cells multiplied and organized into tissue within a few days. Tests showed that the BEHM was capable of generating pulsating forces and reacting to stimulation more like real muscle than ever before.

Previously, the group described the results of a self organization strategy, showing that it was possible to engineer heart muscle that closely resembles normal heart muscle physiology without any synthetic scaffolding material. The U-M team and others have also shown how polymeric scaffolds can be used to engineer heart muscle of any shape or size to match the area of the damaged heart muscle ?raising the possibility of engineering customized patches to meet the specific requirements of patients. All of these approaches are described in the recent review article.

The new article, by Birla and lead author Louise Hecker, a graduate student in the U-M Department of Cell & Developmental Biology, describes the “bioreactor?that the team uses to grow their BEHM. It also details many other discoveries that have been made by other teams using different ce
'"/>

Source:University of Michigan Health System


Page: 1 2 3 4

Related biology news :

1. Ants Genetic Engineering Leads To Species Interdependency
2. UCSD team discovers specialized, rare heart stem cells in newborns
3. Single stem cells from bone heal a broken heart
4. Python a hearty eater
5. Columbia study shows widely used artery clearing device does not help patients during heart attack
6. Researchers reveal secret of key protein in brain and heart function
7. Stem cell therapy successfully treats heart attack in animals
8. New defibrillator signals doctor of patients irregular heartbeat or device malfunction
9. Survival of heart patients on beta-blockers varies greatly with genetic variation
10. Chemical band-aid prevents heart failure in mice with muscular dystrophy
11. MicroRNA tweaks protein that controls early heart development
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Engineering the heart piece piece

(Date:7/31/2015)... La 10 th International Conference on Genomics ... 22 al 25 de octubre de 2015 en ... conferencia celebra su décimo aniversario. Desde su inauguración en el ... reuniones anuales más influyentes del mundo en el campo ,ómico, ... y mejores a nivel científico. ICG-10 se ...
(Date:7/30/2015)... 2015 Cellecta, Inc., a U.S.-based provider ... and biomarker discovery, announced the release of its ... all human protein coding genes. CRISPR technology enables ... gene,s function. Cellecta,s new Human Whole Genome CRISPR ... so that researchers can investigate in a single ...
(Date:7/23/2015)... July 23, 2015 Research and Markets ... the "Global Outlook of the Biometrics Industry ... The global biometrics market is likely ... commercial applications owing to the uptake of multiple ... transformation that enhances the growth of biometrics in ...
Breaking Biology News(10 mins):La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3
... the nature of crowds playing Foldit called some strategies ... methods already used by protein scientists., Gamers made headlines ... central to research on AIDS. Today, in a ... National Academy of Sciences, University of Washington researchers ...
... 2011 AVT, Inc. (formerly Automated Vending Technologies) (Ticker: ... provide a new line of Secure Automated Retailing Systems ... This new system provides extra security for automated ... customer is critical. AVT worked with ...
... characterize the genes involved in wood formation in poplar trees ... wood as a feedstock for biofuels production. "This ... work of other biofuels researchers who develop better and more ... Beers, professor of horticulture and the lead investigator on the ...
Cached Biology News:Paper uncovers power of Foldit gamers' strategies 2Paper uncovers power of Foldit gamers' strategies 3AVT Partners with MedBox to Provide New Biometric Fingerprint Recognition for Secure Automated Retailing 2Genomics of wood for biofuels production investigated 2
(Date:7/30/2015)... ... July 30, 2015 , ... ... field clinical study of its canine osteoarthritis stem cell product, currently under development ... City, KS) and will be marketed in the US by Aratana. This product, ...
(Date:7/30/2015)... customers across the globe, ISN improves the efficiency and effectiveness of contractor management systems. ... and reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers In More Than 80 Countries ... Headquartered in Dallas, TX , ISN has additional offices in ...
(Date:7/30/2015)... Pa. , July 30, 2015  Discovery ... that it has received the second $1.0M tranche ... Innovation Research (SBIR) grant valued at up to ... company,s aerosolized KL4 surfactant as a potential medical ... injury.  Discovery Labs was awarded an initial $1.0 ...
(Date:7/29/2015)... Sanofi, a global and ... quarter of 2015. CEO Olivier Brandicourt ... in different businesses. Watch video interview ... Topics covered in the interview include:  ... Performance drivers - Diabetes ...
Breaking Biology Technology:VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3
... U.S. Secretary of Health and Human Services Tommy Thompson has ... , a provider of information systems for high-acuity care areas ... room and the intensive care unit. , ,Thompson began his ... Wisconsin's state Assembly. He was elected assistant Assembly minority leader ...
... has approved a $500,000 start-up grant for the ... group for classified, defense-related projects. , ,The ... also initially include the UW System, the Medical ... and the Milwaukee School of Engineering. , ,The ...
... National LambdaRail Two UW-Madison computer science professors, ... have been named to the National LambdaRails Networking Researching ... the high-speed fiber optic networks research goals. , ,The ... educational groups across the country, which over the past ...
Cached Biology Technology:Wisconsin consortium aims for defense business 2Two UW-Madison professors named to National LambdaRail Networking Research Council 2
... enables complete conversion of unmethylated cytosines ... hours. The highly sensitive method utilizes ... and a spin-column-based purification and desulfonation ... results for all downstream applications. The ...
... Shimadzus GCMS-QP2010s Gas Chromatograph/Mass Spectrometer, ... of the GCMS-QP2010 Plus, offers high ... with an excellent performance-to-cost ratio. Like ... patented constant linear velocity for optimum ...
... enterprise microarray informatics platform for microarray data storage, ... and use it forever without paying ongoing license ... Acuity has all the analysis tools you need ... quality control statistics and normalization, all the way ...
... Pro is the industry standard microarray image ... of imaging and analysis tools, visualizations, automation ... Pro is included with every GenePix scanner, ... third-party scanners and all types of arrays. ...
Biology Products: