Navigation Links
Engineered yeast speeds ethanol production

Scientists from Whitehead Institute and MIT have engineered yeast that can improve the speed and efficiency of ethanol production, a key component to making biofuels a significant part of the U.S. energy supply.

Currently used as a fuel additive to improve gasoline combustibility, ethanol is often touted as a potential solution to the growing oil-driven energy crisis. But there are significant obstacles to producing ethanol. One is that high ethanol levels are toxic to the yeast that ferments corn and other plant material into ethanol.

By manipulating the yeast genome, the researchers have engineered a new strain of yeast that can tolerate elevated levels of both ethanol and glucose, while producing ethanol faster than un-engineered yeast.

The work will be reported in the Dec. 8 issue of Science.

Fuels such as E85, which is 85 percent ethanol, are becoming common in states where corn is plentiful; however, their use is mainly confined to the Midwest because corn supplies are limited and ethanol production technology is not yet efficient enough.

Boosting efficiency has been an elusive goal, but the researchers, led by Hal Alper, a postdoctoral associate in the laboratories of MIT chemical engineering professor Gregory Stephanopoulos and Whitehead Member Gerald Fink, took a new approach.

The team targeted two proteins that belong to a class of proteins called transcription factors. These proteins typically control large groups of genes, regulating when these genes are turned on or shut off.

When the researchers altered a transcription factor called the TATA-binding protein, it caused the over-expression of at least a dozen genes, all of which were found to be necessary to elicit an improved ethanol tolerance. As a result, that strain of yeast was able to survive high ethanol concentrations.

In addition, this altered strain produced 50 percent more ethanol during a 21-hour period than normal yeast.

The prospect of using this approach to engineer similar tolerance traits in industrial yeast could dramatically impact industrial ethanol production, a multi-step process in which yeast plays a crucial role. First, cornstarch or another polymer of glucose is broken down into single sugar (glucose) molecules by enzymes, then yeast ferments the glucose into ethanol and carbon dioxide.

Last year, four billion gallons of ethanol were produced from 1.43 billion bushels of corn grain (including kernels, stalks, leaves, cobs, husks) in the United States, according to the Department of Energy. In comparison, the United States consumed about 140 billion gallons of gasoline.
'"/>

Source:Whitehead Institute for Biomedical Research


Related biology news :

1. Engineered molecule amplifies bodys immune response
2. Engineered skin offers clues to melanoma development
3. Engineered Stem Cells Show Promise For Sneaking Drugs Into The Brain
4. Engineered mouse mimics cognitive aspects of schizophrenia
5. Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure
6. Examination of internal wiring of yeast, worm, and fly reveals conserved circuits
7. Navigating an integrated yeast network
8. After the yeast is gone bacteria continue to develop flavor of sparkling wine
9. GlycoFi announces the first production of antibodies with human glycosylation in yeast
10. From a lowly yeast, researchers divine a clue to human disease
11. GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)... the first robotic gym for the rehabilitation and functional motor sense evaluation ... Genoa, Italy . The first 30 robots will be available from ... . The technology was developed and patented at the IIT laboratories ... Technology thanks to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
(Date:5/6/2017)... , May 5, 2017 ... just announced a new breakthrough in biometric authentication ... exploits quantum mechanical properties to perform biometric authentication. These ... smart semiconductor material created by Ram Group and ... finance, entertainment, transportation, supply chains and security. Ram ...
(Date:4/18/2017)... , April 18, 2017  Socionext Inc., a global expert ... a media edge server, the M820, which features the company,s hybrid ... software provided by Tera Probe, Inc., will be showcased during the ... the NAB show at the Las Vegas ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... BALTIMORE, Md. (PRWEB) , ... October 11, 2017 ... ... for digital pathology, announced today it will be hosting a Webinar titled, “Pathology ... of  Advanced Pathology Associates , on digital pathology adoption best practices and how ...
(Date:10/11/2017)... Florida (PRWEB) , ... October 11, 2017 , ... ... Drug Administration (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 ... for the treatment of osteosarcoma. SBT-100 is able to cross the cell membrane ...
(Date:10/10/2017)... International research firm Parks Associates announced today that ... TMA 2017 Annual Meeting , October 11 in Scottsdale, ... security market and how smart safety and security products impact the competitive ... Parks Associates: Smart Home Devices: Main ... "The residential security market has experienced continued ...
(Date:10/9/2017)... ... ... The award-winning American Farmer television series will feature 3 Bar Biologics in ... 8:30aET on RFD-TV. , With global population estimates nearing ten billion people by ... feed a growing nation. At the same time, many of our valuable resources are ...
Breaking Biology Technology: