Navigation Links
Engineered skin offers clues to melanoma development

up to six months and sacrificed at different time points to examine the skin grafts for signs of melanoma and to determine whether the cancer had metastasized.

The researchers began by introducing several mutant genes commonly found in human melanomas. These included genes that interfere with the retinoblastoma (Rb) and p53 tumor suppressor pathways, which normally act to keep cell growth in check, as well as human telomerase reverse transcriptase (hTERT), the enzyme that protects the ends of chromosomes during cell division. This enzyme is associated with the progression of many cancers. None of these mutant genes, when introduced individually or in combination, led to cancerous growth. But when a mutant form of Ras--produced by an oncogene that sends growth signals to a cell--was added to this combination, it produced clinical features of invasive human melanoma: darkly pigmented skin that progressed to ulcerated tumor nodules.

Melanoma was observed as early as one month after the oncogenic combination was introduced. The tumors demonstrated aggressive local invasion but did not metastasize.

Next, Chudnovsky and colleagues investigated whether interfering with either the Rb or p53 pathways could trigger melanoma. They found that in combination with Ras and hTERT, the expression of cyclin-dependent kinase 4 (CDK4),which promotes cell growth and inhibits Rb function, induced invasive melanoma in human tissue. Similarly, inhibition of p53, when combined with Ras and hTERT, resulted in invasive melanoma.

The scientists also investigated the role of elevated telomerase activity. In combination with other cancer genes, hTERT, the active protein in the enzyme telomerase, caused progressively invasive melanoma. In contrast, melanocytes that did not receive hTERT remained in an early stage of benign growth.

Finally, the team looked at the PI3K and Raf pathways, frequently implicated in the development of melanoma. They found the exp
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3

Related biology news :

1. Engineered molecule amplifies bodys immune response
2. Engineered Stem Cells Show Promise For Sneaking Drugs Into The Brain
3. Engineered mouse mimics cognitive aspects of schizophrenia
4. Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure
5. Engineered yeast speeds ethanol production
6. Protein offers way to stop microscopic parasites in their tracks
7. Gene silencing technique offers new strategy for treating, curing disease
8. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
9. GM crop that holds on to its seeds offers higher yields
10. Novel enzyme offers new look at gene regulation
11. Technique offers new view of dynamic biological landscape
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Engineered skin offers clues melanoma development

(Date:9/15/2014)... to a morphine regimen can result in better pain ... reduce the dosage of the opioid needed to be ... Indiana University. , The result could bring significant relief ... often felt in the arms and legs and associated ... unmet need for better treatments for neuropathic pain," said ...
(Date:9/15/2014)... all kingdoms of life and constitute a large family ... activities. The presence of halogen substituents in many bioactive ... , One of the Holy Grails in ... incorporation of a halogen atom into a complex natural ... the most inert chemical bonds known in an organic ...
(Date:9/15/2014)... Australia,s leading coral reef ecologists fears that reef biodiversity ... survival that we once thought. , In an international ... Centre of Excellence for Coral Reef Studies (Coral CoE) ... important species within reef ecosystems. , In coral reefs, ... jobs that keep the ecosystem safe and functioning. ...
Breaking Biology News(10 mins):IU study: Combining epilepsy drug, morphine can result in less pain, lower opioid doses 2Pitt chemical biologist finds new halogenation enzyme 2Specialized species critical for reefs 2
... Top 100 Internet Retailers, BOISE, Idaho, Oct. ... provider of fraud control for ecommerce merchants, has ... National Account Sales,directors. Together, they bring Kount customers ... ecommerce fraud control and online,payments., Scott Lewer ...
... pine beetle moves through the forest boring tunnels inside the bark ... competitor. The helper is a fungus that the insect plants inside ... is a tiny, hitchhiking mite, which likewise carries a fungus for ... millennia-old arrangement has grown even more curious. Writing in the Oct. ...
... experiments, biomedical engineers at the Johns Hopkins University School of ... can slow or stop the growth of cells that make ... in the Proceedings of the National Academy of Sciences, ... treatments to fight diseases that depend on the growth of ...
Cached Biology News:Kount Lands Veteran Fraud Experts From Retail Decisions and iovation 2Wielding microbe against microbe, beetle defends its food source 2Wielding microbe against microbe, beetle defends its food source 3Discovery of natural compounds that could slow blood vessel growth 2
(Date:9/15/2014)... (PRWEB) September 15, 2014 Hydro ... ) announced today that it will be partnering ... CA ( http://www.proteaf.com ) for implementing its Shock ... value continuous processing. Continuous flow chemistry through ... chemical, pharmaceutical and petrochemical markets for decades. ...
(Date:9/14/2014)... of ways, including by modifying the protein structure. In ... and perform no or even the "wrong" function: in ... such as Alzheimer,s, Parkinson,s or cystic fibrosis. Some of ... molecules of the same type and congregate into insoluble ... cells and tissues and make people ill. , ...
(Date:9/13/2014)... 2014 Boehringer Laboratories Inc., with a ... to announce the successful broadcast of a live surgery ... Claros, MD, FACS, FAMBS, and Maher El Chaar, MD, ... System. , This sleeve gastrectomy surgery was performed ... than four hundred surgeons from around the world during ...
(Date:9/12/2014)... Arthur Kay , the 23-year-old British founder of environmentally ... Challenge 2014. The jury, chaired by Ellen MacArthur ... final in Amsterdam to realize ... uses a patented process to upcycle waste coffee grounds ... used for powering buildings and transport systems. Bio-bean is ...
Breaking Biology Technology:Hydro Dynamics Partners with the Continuous Flow Chemistry Experts of Proteaf Technologies 2Measuring modified protein structures 2Measuring modified protein structures 3Boehringer Laboratories, Inc. Announces Live Surgery Using Innovative System to Calibrate Sleeve Gastrectomy 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 2Green Startup Bio-Bean Wins $680,000 in Postcode Lottery Green Challenge 3
... word of the day last Thursday at the ... representatives from across Wisconsin told the tales of their ... broad spectrum of industries represented, ranging from prescription drugs ... radio frequency identification technology could be tailored to fit ...
... the economic downturn in Wisconsin to be over. , ,You dont ... allow me to sing a chorus of Happy Days Are Here ... , ,A pile of available evidence proclaims that Wisconsins economy is ... to 4.8 percent in May, down from 5.1 percent in April. ...
... a national priority , ,MADISON - Kathleen Heuer, ... the U.S. Department of Health and Human Services, and ... of the National Health Information Infrastructure at HHS, will ... being held June 22-23, at the Fluno Center in ...
Cached Biology Technology:Upgrading your business with RFID 2Upgrading your business with RFID 3The economy has come roaring back or is that roar just a purr? 2The economy has come roaring back or is that roar just a purr? 3U.S. Health and Human Services officials to speak at the Digital Healthcare Conference 2
Anti-hamster Ig HRP detection kit...
The 50 ml Magnetic Separation Rack is designed to be used for small-scale separations using magnetic particles. ,Capacity: four 50 ml tubes. ,Magnets: Neodymium rare earth permanent magnets....
...
Highly efficient electroporation solution suitable for transfection of plasmid DNA, oligonucleotides and siRNA. Compatible with all common electroporators....
Biology Products: