Navigation Links
Engineered molecule amplifies body's immune response

lecule. By increasing the efficiency of the Stat1 molecule, the host could have the benefits of increased Stat1 signaling even at the low levels of interferon normally present in the body. Their results appear as the "Paper of the Week" in the October 7 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal.

"Our paper is really quite simple in conceptual terms," says Dr. Holtzman. "It is well known that interferon provides a benefit to people by protecting them against infectious diseases and cancer. Unfortunately, administration of interferon is costly and short-lived and has significant side effects. We simply reasoned that it might be possible to improve the benefits of interferon by enhancing the way it produces its beneficial effects. We therefore improved a molecule, known as Stat1, that is responsible for relaying the benefits of interferon in the body."

Their initial in vitro results were promising, and the engineered Stat1 molecule exhibited an increased responsiveness to interferon. Following up on these discoveries, Dr. Holtzman and his colleagues are currently performing gene transfer experiments, using both recombinant viruses and transgenic mice, to establish the benefits of hyper-responsive Stat1 in vivo for treating viral infection and cancer. They are also screening for drugs that might increase Stat1 responsiveness.

These experiments may eventually lead to many improvements in cancer therapy as well as the treatment of other infections. Basically, any situation in which interferon hyper-responsiveness might be beneficial will profit from Dr. Holtzman's research.

"One could use our strategy of improving Stat1 efficiency during the winter months in patients who are at risk for developing serious viral infections, for example children with asthma, or heart disease, or immune compromise," suggests Dr. Holtzman. "It may also be of benefit in situations where inter
'"/>

Source:American Society for Biochemistry and Molecular Biology


Page: 1 2 3

Related biology news :

1. Engineered skin offers clues to melanoma development
2. Engineered Stem Cells Show Promise For Sneaking Drugs Into The Brain
3. Engineered mouse mimics cognitive aspects of schizophrenia
4. Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure
5. Engineered yeast speeds ethanol production
6. Chemists create Superbowl molecule; May lead to better health
7. Key molecule in plant photo-protection identified
8. Inflammatory molecules released by pollen trigger allergies
9. Researchers discover molecule that causes secondary stroke
10. Yale researchers identify molecule for detecting parasitic infection in humans
11. Scientists identify molecule that regulates well-known tumor suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Engineered molecule amplifies body immune response

(Date:7/9/2014)... era of increasing concern about the prevalence of ... a promising new pathway to disabling disease: blocking ... The scientists showed how bacterial siderophore, a small ... to fan bacterial growth as well as ... this infection process. Their findings appear in a ...
(Date:7/9/2014)... first-ever global census of Adlie penguins shows that ... 53 percent larger than previously estimated. Adlie penguins ... to monitor and understand the effects of climate ... By using high-resolution satellite imagery, researchers from Stony ... a new method that permits regular monitoring of ...
(Date:7/9/2014)... accrue. To completely and systematically archive this body ... researchers in the life sciences spend a quarter ... online survey of 70 people working in biology ... Information Technology FIT in Sankt Augustin. Many of ... or structured approach to data collection in their ...
Breaking Biology News(10 mins):Bacteria hijack plentiful iron supply source to flourish 2New study finds that Adélie penguin population is on the rise 2New study finds that Adélie penguin population is on the rise 3Managing the data jungle 2Managing the data jungle 3
... Traffic accidents involving wildlife are on the rise in Europe. ... be useful for increasing safety and preventing human and animal ... researchers have established at what time, on what day of ... roe deer are most likely to take place. Car ...
... that cancerous tumors grow collections of abnormal blood cells, the ... new evidence in an animal model suggests that blood vessels ... same purposeand could provide the key to a new way ... L. Makey, Edmund Chinchar, Carissa Howie, and Lucio Miele, all ...
... Animal sanctuaries can play an important role in rehabilitating goats ... scientists at Queen Mary, University of London. In ... moods in 18 goats, nine of which had endured poor ... shelter before arriving at a sanctuary. They created a spatial ...
Cached Biology News:Roe deer more likely to be run over at nightfall on a Sunday in April 2Drug reduces fat by blocking blood vessels 2Drug reduces fat by blocking blood vessels 3Rescue me: New study finds animals do recover from neglect 2
(Date:1/15/2014)... 2014 The Pittcon Organizing Committee is pleased ... Safety Tech , an e-Journal and producer of ... the second year for the co-location of Food Labs Conference ... provides that the registration fee to attend the two-day Food ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Look inside ... hard-working items for the lab, from fluid handling to ... (GIS)—ready to ship when you order. , Preferred ... Pumps , from the L/S® model for precise flow ...
(Date:1/15/2014)... California , January 15, 2014 Oxford ... today announced the appointment of Thomas C Reynolds MD, PhD ... years, development experience gained in the biotechnology industry, most recently ... am delighted to welcome Tom at this transformative time for ...
(Date:1/15/2014)... This webinar will focus on EMA ... assessment in biosimilars. , Regulatory frameworks are evolving many ... however the complex nature of biopharmaceuticals makes the demonstration ... extremely challenging. Based on the specific aspects of biosimilar ...
Breaking Biology Technology:Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2
... Sept. 25 /Xinhua-PRNewswire-FirstCall/ -- 3SBio Inc.,(Nasdaq: ... on researching,developing, manufacturing and marketing biopharmaceutical products,primarily ... filed with the Chinese,State Food and Drug ... IU,dosage formulation of EPIAO for the treatment ...
... of Business ... Development Activities -, LA JOLLA, Calif., Sept. ... it will transition from a,discovery and development company to a development-only ... will,streamline operations through the shut down of its discovery operations,and seek ...
... Cells and Other ... Development Programs, ROCKVILLE, Md., ... immunotherapeutics to treat,autoimmune disorders, cancer and infectious diseases, today announced that,it ... led by,Nextech Venture, included additional new investors Arcus Ventures, Innovis,Investments and ...
Cached Biology Technology:3SBio Inc. Files for SFDA Approval of High-dose (36,000 IU) EPIAO 23SBio Inc. Files for SFDA Approval of High-dose (36,000 IU) EPIAO 3TorreyPines Therapeutics Strategically Repositions as Development Company Focusing on Three Versatile Lead Compounds 2TorreyPines Therapeutics Strategically Repositions as Development Company Focusing on Three Versatile Lead Compounds 3TorreyPines Therapeutics Strategically Repositions as Development Company Focusing on Three Versatile Lead Compounds 4MacroGenics Raises $25M in Series D-2 Financing 2MacroGenics Raises $25M in Series D-2 Financing 3MacroGenics Raises $25M in Series D-2 Financing 4
Tube-O-DIALYZER Floats, small....
Feline Rhinotracheitis Virus...
Ezrin/Radixin/Moesin Antibody...
Rabbit polyclonal to Survivin DEx3 ( Abpromise for all tested applications). entrezGeneID: 332 SwissProtID: O15392...
Biology Products: