Navigation Links
Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure

.

The team then induced electrical activity in these engineered tissues as would occur in ventricular tachycardia and attempted to halt it with pace-setting pulses.

"In the beginning, there is a single rotating wave -- the 'culture dish' analog of ventricular tachycardia," Bursac said. "After a short period, we applied trains of pulses in an attempt to terminate this wave."

The pulses successfully halted the wave 80 percent of the time, they reported. In the remaining cases, however, the pulses converted the single wave into multiple waves that continued to activate the cardiac cells at an accelerated rate.

"In other words, instead of terminating it, the pacing actually perpetuated and worsened the initial condition in about 20 percent of the cases," Bursac said. "That percentage approximates the frequency with which this is thought to occur in patients with implanted defibrillators."

The researchers' analysis revealed a possible explanation for the two responses. They found significant differences in propagation of electrical activity through the engineered tissues between those that responded to pace-setting shocks by halting their aberrant rhythm, and those that responded by accelerating their rhythm.

Should such characteristic patterns hold in patients, physicians could potentially use them to identify those people for whom defibrillators are more likely to worsen abnormal heart rate, Bursac said.

So-called implantable cardioverter defibrillators (ICD) monitor the timing of heartbeats and can deliver small or large shocks to correct arrhythmias. Such devices have become increasingly common for patients who have experienced arrhythmias and are therefore at increased risk for future rhythm abnormalities, Bursac said.

In patients with implanted defibrillators, the devices often attempt to terminate ventricular tachycardia by delivering electrical pulses to a single site at a rate slightly higher than
'"/>

Source:Duke University


Page: 1 2 3

Related biology news :

1. Engineered molecule amplifies bodys immune response
2. Engineered skin offers clues to melanoma development
3. Engineered Stem Cells Show Promise For Sneaking Drugs Into The Brain
4. Engineered mouse mimics cognitive aspects of schizophrenia
5. Engineered yeast speeds ethanol production
6. UCSD team discovers specialized, rare heart stem cells in newborns
7. Single stem cells from bone heal a broken heart
8. Python a hearty eater
9. Columbia study shows widely used artery clearing device does not help patients during heart attack
10. Researchers reveal secret of key protein in brain and heart function
11. Stem cell therapy successfully treats heart attack in animals
Post Your Comments:
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ... "iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & ... http://photos.prnewswire.com/prnh/20130307/600769 ... introduced the fingerprint reading feature with the iPhone 5S. ...
(Date:12/19/2014)... , Dec. 18, 2014  23andMe, Inc., the leading personal genetics ... fine-scale differences in genetic ancestry of individuals from across ... first arrived more than four hundred years ago, ... place for peoples from different continents. This study illuminates how ...
(Date:12/17/2014)... Dec. 15, 2014 Research and Markets ( ... "Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor ... http://photos.prnewswire.com/prnh/20130307/600769 Based on ... Samsung introduces for the first time a fingerprint sensor ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... temperatures in the Northeast Shelf Large Marine Ecosystem during ... to the latest Ecosystem Advisory issued by NOAA,s Northeast ... (SSTs) are the latest in a trend of above ... and part of a pattern of elevated temperatures occurring ...
... Proteins, unlike diamonds, aren,t forever. And when they wear ... back into amino acids, where they will be recycled ... Howard Hughes Medical Institute have identified a new way ... of unwanted and potentially toxic proteins, a finding that ...
... , April 26, 2013  Xencor announced today that MorphoSys AG ... trial of MOR208 in B-cell acute lymphoblastic leukemia (B-ALL). MOR208 ... cytotoxic function for which MorphoSys licensed exclusive worldwide rights from ... the study triggers an undisclosed milestone payment to Xencor. ...
Cached Biology News:Sea surface temperatures reach highest level in 150 years 2Sea surface temperatures reach highest level in 150 years 3Scientists discover new way protein degradation is regulated 2Monoclonal Antibody with Xencor's High ADCC Fc Technology Enters Phase 2 Study in B-cell Acute Lymphoblastic Leukemia 2
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently was ... Pre-Conference seminar on probiotics in San Diego, CA. , ... conference for health care professionals. This year’s pre-conference seminar was ... in health. Dr. Leyer spoke about the emerging topics and ...
(Date:1/22/2015)... , Nueva Jersey , 22 de enero de ... Biomedical Research abre hoy su llamada a nominaciones para ... investigación científica ha hecho, o tiene el potencial para ... humana. Las nominaciones se aceptarán hasta el 15 de ...
(Date:1/22/2015)... PRINCETON, N.J. , Jan. 22, 2015  Derma ... tissue regeneration company focused on advanced wound care, ... from placental tissues, have been added to the ... announcement increases the opportunity for the AMNIOEXCEL® and ...
(Date:12/24/2014)...  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical solutions ... the Company closed its previously announced private placement ... W. Schuler , Birchview Fund LLC and several ... offering expenses.  The proceeds will be used for ...
Breaking Biology Technology:El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... , , Honorees ... to be recognized at Sept. 30 gala ceremony , ... Prix Galien USA will recognize innovative biopharmaceutical drugs and medical technologies ... life at a gala event on September 30. Candidates for the ...
... ALBANY, Ore., Aug. 6 Synthetech, Inc. (OTC Bulletin Board: ... 2010, which ended June 30, 2009. Revenue for the quarter ... million in the first quarter of fiscal 2009. Operating income ... of $314,000 for the same period last year. Net income ...
... , , ST. ... ) today announced the acquisition of cheminformatics company, ChemNavigator(R).com, ... tools used for design, selection and procurement of chemical ... ) comprehensive suite of virtual screening and selection ...
Cached Biology Technology:Prix Galien USA Announces 2009 Final Candidates 2Synthetech Reports First Quarter Fiscal 2010 Results 2Synthetech Reports First Quarter Fiscal 2010 Results 3Synthetech Reports First Quarter Fiscal 2010 Results 4Synthetech Reports First Quarter Fiscal 2010 Results 5Synthetech Reports First Quarter Fiscal 2010 Results 6Sigma-Aldrich Acquires ChemNavigator, Inc., to Provide Researchers With Industry-Leading Chemical Compound Selection and Procurement Services 2Sigma-Aldrich Acquires ChemNavigator, Inc., to Provide Researchers With Industry-Leading Chemical Compound Selection and Procurement Services 3
ExonBio Service provides one-stop recobinant protein shopping from cloning, expression and purification. Price including gene cloning....
... IgG FITC is used as the ... on tissues or culture cells where ... rabbits. It is highly recommended that ... the primary antibody, be included in ...
... x 25 mm; approximately 1 mm thick, ... sections, sandblasted frosted writing ... markings will not rub off or wash off ... store at room temperature ...
1000X solution used for inducing CopyControl™ based vectors to high copy numbers...
Biology Products: