Navigation Links
Engineered Stem Cells Show Promise For Sneaking Drugs Into The Brain

nction of the defective cells at the root of Parkinson's.

"This work shows that stem cells can be used as drug delivery vehicles in the brain," says Svendsen, a professor of anatomy whose laboratory is at the UW-Madison Waisman Center.

The new Wisconsin study, whose lead author is Soshana Behrstock, depended on formative brain cells that were coaxed from blank-slate stem cells. The progenitor neural cells were genetically modified to secrete the growth factor when implanted in the striatum, a large cluster of cells in the brain that controls movement, balance and walking.

To work effectively, the cells in the striatum require dopamine, a chemical that is produced deep in the brain and that travels up nerve fibers to the striatum where it is used to keep critical cells functional. Loss of the ability to produce dopamine is the root cause of Parkinson's, a disease that afflicts about 1.5 million people in the United States.

In the new Wisconsin study, the GDNF-producing cells transplanted in the striatum of animals with a condition like Parkinson's showed not only that a critical drug could be delivered to the right place, but that the drug was delivered in a way that promoted its therapeutic potential. The researchers reported new nerve fiber growth in the striatum and the transport of the critical nerve growth factor GDNF from the striatum to the substantia niagra, the part of the brain that harbors the cells that produce dopamine.

"In Parkinson's, the striatum loses fibers," Svendsen explains. But cells in the striatum exposed to GDNF in the Wisconsin study showed an ability to recover and sprout new fibers.

"It actually seems to work better in the terminal (striatum)," Svendsen says. "The bonus is it gets transported back to the substantia niagra."

The transplanted cells, according to Behrstock, survived and continued to produce GDNF in laboratory animals for up to three months.

One hurdle that needs
'"/>

Source:University of Wisconsin-Madison


Page: 1 2 3

Related biology news :

1. Engineered molecule amplifies bodys immune response
2. Engineered skin offers clues to melanoma development
3. Engineered mouse mimics cognitive aspects of schizophrenia
4. Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure
5. Engineered yeast speeds ethanol production
6. Jump-starting T Cells In Skin Cancer
7. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
8. Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
9. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
10. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
11. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Engineered Stem Cells Show Promise For Sneaking Drugs Into The Brain

(Date:12/19/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has ... America Perimeter Security Systems Market" report to their offering. ... North American perimeter security market is estimated to grow at ... U.S. market holds a larger share in this market, ...
(Date:12/17/2014)... 15, 2014 The Defense Logistics Agency is insourcing ... prevent counterfeit microcircuits from entering into its supply chain. ... microcircuit anti-counterfeit initiative dubbed DNA marking. The capability will ... reliability throughout the supply chain. The new quality control ...
(Date:12/17/2014)... , Dec. 16, 2014  Automation is fundamentally transforming the ... at international borders. Over the past decade, ePassports, biometric ... to self process through border control via eGates and ... of airports, seaports, and land borders across the globe. ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... -- Studies in recent years have demonstrated that binge ... the risk of osteoporosis. Now a Loyola University ... mechanism: Alcohol disturbs genes necessary for maintaining healthy bones. ... new drugs to minimize bone loss in alcohol abusers. ...
... Zecure, a leading,provider of e-commerce fraud ... installed its award-winning Acquirer SAFE suite to,prevent ... to keep,high risk merchants under control., ... Service Providers,(PSPs) keep high-risk merchants under control ...
... along with colleagues from the California Institute of Technology, ... institutions, have unearthed crystalline magnetic fossils of a previously ... of the Paleocene and Eocene epochs, some 55 million ... the Proceedings of the National Academy of Sciences ...
Cached Biology News:Why binge drinking is bad for your bones 2OrbitalPay, LLC Implements Zecure's Acquirer SAFE Solution to Stop Fraudulent E-Commerce Merchants 2Earlier global warming produced a whole new form of life 2
(Date:1/22/2015)... CAMBRIDGE, Mass. , Jan. 22, 2015   GenoSpace , ... suite of tools to enable the broad use of genomic, ... today announced the appointment of Michelle Munson , CEO ... independent director. Logo - http://photos.prnewswire.com/prnh/20150122/170713 ...
(Date:12/25/2014)... The report “Service Quality Management and Telco Customer ... - Global Advancements, Worldwide Forecasts & Analysis (2014-2019)” defines ... forecasting of revenues. , Browse 152 market data ... TOC on “Service Quality Management (SQM) and Telco Customer ...
(Date:12/24/2014)... NEW YORK , Dec. 24, 2014 ... patient care in critical areas, announced the closing of an ... warrants to purchase up to an aggregate 3,500,000 shares of ... and $.01 per warrant.  The warrants have a per share ...
(Date:12/24/2014)... 24, 2014   BioLife Solutions , Inc. (NASDAQ: ... clinical grade hypothermic storage and cryopreservation freeze ... cells and tissues  ("BioLife" or the "Company"), today announced that ... May 4, 2015 (the "Annual Meeting"). Because the ...
Breaking Biology Technology:GenoSpace Expands Board with Appointment of Michelle Munson 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3BioLife Solutions Sets Date for Annual Meeting of Stockholders 2
... Madison, Wis. - It may not rank with the ... Bachelor , but a Madison-based online service is doing a ... service that matches privately held companies with board candidates, has thus ... tempted to veer into another lane on the information super highway. ...
... has been awarded a $2 million grant from the ... of Energy to develop its method of converting glycerol, ... propylene glycol. , ,The grant was awarded as part of ... which was established to develop of technologies that make bio-based ...
... The Center for Advanced Technology and Innovation , a ... commercial life into unused and underused technologies, is taking ... ,If successful at facilitating the launch of new products ... in Wisconsin and elsewhere while building connections for further ...
Cached Biology Technology:Online service makes board connections 2Online service makes board connections 3Virent lands $2M grant for chemical production 2CATI takes tech transfer model national 2CATI takes tech transfer model national 3
... Synergistic enzyme mix (Thermoprime Plus DNA ... At least four times higher fidelity than ... of standard Taq DNA polymerase, Amplifies DNA ... PCR, long PCR, PCR for cloning and ...
... Assay Kit (E-22013) provides,researchers with a ... lysozyme,activity in solution. This fluorescence-based assay ... U/mL (Figure 1). The assay,measures lysozyme ... are labeled to such a degree ...
... An immuncapture enzyme-activity assay based on ... captured on monoclonal antibody coated microtiter plate. ... standards, samples or controls, 2nd ... The assay is intended for the determination ...
... HT is designed for extended ... HT is ideal for applications ... primer extension assays. iEMS Incubator/Shaker ... one-cabinet model, allowing the capacity ...
Biology Products: