Navigation Links
Energy management in cells may hold key to cancer defense

In an ongoing effort to fight disease by manipulating energy regulation of cells, a collaborative study led by Dartmouth Medical School (DMS) has demonstrated that cells lacking a tumor-suppressing kinase called LKB1 can still maintain healthy energy levels when they become stressed. This energy regulation is essential for keeping cells from dying off too quickly. The study's results could signal new advances for combating cancerous tumor growth, but also type 2 diabetes and obesity.

The study, published in the August 12 issue of the Journal of Biological Chemistry (JBC), was headed by Dr. Lee Witters, Eugene W. Leonard 1921 Professor of Medicine and Biochemistry at DMS and of Biological Sciences at Dartmouth College, who has researched kinases for over 25 years. Kinases encompass a large family of enzyme proteins that play key roles in the workings of most animal cells. He has focused much of his research on the AMP-activated kinase (AMPK) which responsible for managing energy within cellular pathways.

"A cell's energy level is critical to its survival," explains Witters, who likens a low-energy cell to a car with no gas in its tank. "In a previous study, we found that the cellular "gas gauge," AMPK, can turn around and alter any deficits in the cell if it is turned on by the kinase LKB1. In this JBC study, we wanted to see if AMPK could also be turned on by something besides LKB1."

"We decided to work with cervical and lung cancer cells because LKB1 is absent from the cellular pathway," said Rebecca Hurley, lead author of the study and a graduate student in the Molecular and Cellular Biology Program at Dartmouth. Working closely with scientists at St. Vincent's Institute in Australia and Duke University, the DMS team concluded that two kinases in these cancer cells, CaMKKα and CaMKKβ, are able to regulate AMPK independent of LBK1.

"With the addition of these two kinases, we think we have all nearly the players re
'"/>

Source:Dartmouth Medical School


Page: 1 2

Related biology news :

1. Special Imaging Study Shows Failing Hearts Are Energy Starved
2. Leptin-signaling Protein Maintains Normal Body Weight And Energy Balance In Mice
3. GeneNotes - A novel information management software for biologists
4. Study of energy and health in Africa focuses spotlight on charcoal and forest management
5. Water management in cells
6. Aquatic plants may hold key to advancing plant disease management
7. Saharas edge studied from ground, air and space to improve water management
8. Madagascan tropical forests return thanks to better management and well-defined ownership
9. Wisconsin scientists grow critical nerve cells
10. Spleen may be source of versatile stem cells
11. Researchers discover way to make cells in the eye sensitive to light
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Energy management cells may hold key cancer defense

(Date:9/18/2014)... A new GSA Bulletin study uses ... Rio Puerco and Chaco Wash in northern New Mexico, ... salt cedar and willow, investigators were able to precisely ... They then combined this data with aerial imagery, LiDAR, ... of these arroyos. , Arroyos are deep, oversized channels ...
(Date:9/18/2014)... novel robotic system that can operate inside the bore ... part of a biomedical research partnership program at Brigham ... determining if the robot, in conjunction with real-time MRI ... less costly, and less discomforting for the patient. The ... cancer therapies with greater precision. , Developed by a ...
(Date:9/18/2014)... The fall foliage season that prompts millions of Americans to ... later and possibly last a little longer within a century, ... leaf peeping in some areas of the United States as ... report in the journal Global Ecology and Biogeography . ... that is the state tree of New Hampshire could ...
Breaking Biology News(10 mins):Tree rings and arroyos 2Tree rings and arroyos 3Tree rings and arroyos 4Tree rings and arroyos 5Tree rings and arroyos 6Tree rings and arroyos 7Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5Fall foliage season may be later, but longer on warmer Earth 2Fall foliage season may be later, but longer on warmer Earth 3Fall foliage season may be later, but longer on warmer Earth 4
... (miRNAs) tiny strands of non-protein-coding RNAs start ... strands get chopped up by a special kind of ... shorter functional form. The resulting miRNAs bind to messenger ... thus regulating the levels of hundreds of different proteins. ...
... development is affected by nature or nurture our genetic ... we live, according to research funded by the Medical Research ... today in the journal Molecular Psychiatry , researchers from ... of Psychiatry studied data from over 6,700 families relating to ...
... June 11, 2012 /PRNewswire-iReach/ -- FirstMark, the ... Prediman K. (PK) Shah has joined it,s Scientific Advisory ... Cedars-Sinai Professorial Series, and Director of the Division of ... Atherosclerosis Research Center at Cedars-Sinai Medical Center where he ...
Cached Biology News:Living microprocessor tunes in to feedback 2Nature or nurture? It may depend on where you live 2Nature or nurture? It may depend on where you live 3FirstMark Welcomes Renowned Cardiologist and Researcher Dr. Prediman K. Shah to Scientific Advisor Board 2FirstMark Welcomes Renowned Cardiologist and Researcher Dr. Prediman K. Shah to Scientific Advisor Board 3
(Date:9/19/2014)... simple. From crop yields to disease risks, the biological ... "complex traits." Just as for heightthe textbook example of ... disease are shaped by multiple genetic and environmental influences, ... track down such genes, geneticists typically mate two individuals ... and a small mouseand then study their descendents, looking ...
(Date:9/19/2014)... Florida , September 19, 2014 ... medical technology, development of emerging drug systems and advanced ... Benton, Dickinson and Company (NYSE: BDX ), ... Regado Biosciences Inc. (NASDAQ: RGDO ), Sangamo ... Inc. (NASDAQ: HOLX) Pressure BioSciences, Inc. (OTCQB: ...
(Date:9/19/2014)... 19, 2014 Cereal grain scientists, ... will gather October 5–8, 2014, for the AACC ... Convention Center in Providence, Rhode Island. The comprehensive ... of food scientists, chemists, microbiologists, nutritionists, and those ... production management. To date, 1,000 attendees have registered ...
(Date:9/18/2014)... September 18, 2014 HealthTronics, ... and interventional radiology products and services, announced that ... cryotherapy and cryoablation) versus external beam radiotherapy (EBRT) ... the American Urological Association (MAAUA) Annual Meeting in ... Relative Effectiveness of Cryosurgery and External Beam Radiation ...
Breaking Biology Technology:Want to link genes to complex traits? Start with more diversity 2Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 2Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 3Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 4Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 5Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 6Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 7Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2
... 31 Cardinal Health, a,global provider of products ... health care, today announced a three-year agreement with,Prime ... managers,to serve as its primary supply chain partner ... Prime Therapeutics managed more than $8.2 billion in ...
... Pa., July 31 The Quigley,Corporation (Nasdaq: QGLY ... million, for the second quarter ended June 30, 2008,compared ... June 30,2007. For the six months ended June 30, ... reported for the six months ended June 30, 2007., ...
... Inc. (Nasdaq: ALXA ) announced today that it ... 30, 2008, on Wednesday,August 6, 2008, following the close ... investor conference call to discuss the financial,results and other ... day, Thursday, August 7, 2008. A replay of the ...
Cached Biology Technology:Cardinal Health, Prime Therapeutics Sign Primary Distribution Agreement 2The Quigley Corporation Reports Second Quarter 2008 Results: Continues Investment in Pharmaceutical R&D Future 2The Quigley Corporation Reports Second Quarter 2008 Results: Continues Investment in Pharmaceutical R&D Future 3The Quigley Corporation Reports Second Quarter 2008 Results: Continues Investment in Pharmaceutical R&D Future 4The Quigley Corporation Reports Second Quarter 2008 Results: Continues Investment in Pharmaceutical R&D Future 5The Quigley Corporation Reports Second Quarter 2008 Results: Continues Investment in Pharmaceutical R&D Future 6Alexza to Announce 2008 Second Quarter Financial Results and Update Its Clinical Pipeline on Wednesday, August 6, 2008 2Alexza to Announce 2008 Second Quarter Financial Results and Update Its Clinical Pipeline on Wednesday, August 6, 2008 3
... Accurate To score SNPs, ... sequencing, the gold standard in DNA analysis. ... The polymorphic locus can be confirmed by ... DNA sequencing also provides sequence context information, ...
... basic power supply are used for submerged horizontal ... This Model 192 cell includes a buffer tank, ... with fluorescent ruler, and a gel caster. The ... provides output of 10-300 V, 4-400 mA, and ...
The imaging screen-K (Kodak), tritium, is a 20 x 25 cm storage phosphor screen that is used for the quantitation and imaging of 32P, 33P, 35S, 14C, and 3H....
The filter 695RDF55 Reflect 635 for the Molecular Imager FX is a band pass filter for Cy5 and Alexa Fluor 635 dyes....
Biology Products: