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Embryonic patterning makes the feathers fly

Analyses of fluorescent-labeled cells confirmed an increase in mesenchymal cell motility following MAPK pathway inhibition. In the controls, rudimentary feather bud epithelia emerge by cell rearrangements and coordinated cell shape elongation. In inhibitor-treated explant epithelia, cells remain cobblestone shaped and randomly arranged.

While the chicken feather movie poses no threat to Hollywood, the researchers say that watching the formative process of stripes versus dots play out was fascinating. From those feathery patterns, a team of theoretical biologists was able to develop a mathematical model that simulated the process of periodic pattern formation. This kind of basic work can throw light on health problems like developmental disorders, on questions in evolutionary biology, and on new biotech possibilities including tissue engineering.
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Source:American Society for Cell Biology


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