Navigation Links
Elusive HIV shape change revealed; Key clue to how virus infects cells

Structural biologists at Children's Hospital Boston and Harvard Medical School have shown how a key part of the human immunodeficiency virus (HIV) changes shape, triggering other changes that allow the AIDS virus to enter and infect cells. Their findings, published in the Feb. 24 issue of the journal Nature, offer clues that will help guide vaccine and treatment approaches.

Researchers led by Howard Hughes Medical Institute Investigator Stephen Harrison, PhD, and Bing Chen, PhD, focused on the gp120 protein, part of HIV's outer membrane, or envelope. gp120's job is to recognize and bind to the so-called CD4 receptor on the surface of the cell HIV wants to infect. Once it binds, gp120 undergoes a shape change, which signals a companion protein, gp41, to begin a set of actions that enable HIV's membrane to fuse with the target cell's membrane. This fusion of membranes allows HIV to enter the cell and begin replicating.

The structure of gp120 after it binds to the CD4 receptor and changes its shape was solved several years ago by another group. Harrison and Chen have now described gp120's structure before the shape change, yielding vital before-and-after information on how the molecule rearranges itself when it encounters the CD4 receptor.

"Knowing how gp120 changes shape is a new route to inhibiting HIV ?by using compounds that inhibit the shape change," says Harrison. He notes that some HIV inhibitors already in development seem to inhibit the shape change; the new findings may help pin down how these compounds work and hasten their development into drugs. "The findings also will help us understand why it's so hard to make an HIV vaccine, and will help us start strategizing about new approaches to vaccine development."

The studies, performed in the Children's Hospital Boston Laboratory of Molecular Medicine, used the closely related simian immunodeficiency virus (SIV) as a stand-in for HIV. By aiming an X-ray beam through a crystallized
'"/>

Source:Children's Hospital Boston


Page: 1 2

Related biology news :

1. Elusive salamanders have role in developing new sampling models
2. Elusive rust resistance genes located
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Scientists reveal the shape of a protein that helps retroviruses break into cells
5. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
6. Divergent life history shapes gene expression in brains of salmon
7. Beyond genes: Lipid helps cell wall protein fold into proper shape
8. Mechanism regulating tooth shape formulation found
9. MicroRNAs have shaped the evolution of the majority of mammalian genes
10. The shape of things to come: Morphology database going global
11. Pleasing plant shapes explained by new computer model
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Elusive HIV shape change revealed Key clue how virus infects cells

(Date:8/22/2014)... , August 22, 2014 ... ) has announced the addition of ... 2014-2018"  report to their offering.  ... ,Biometrics is a technology that helps ... on their physical or behavioral features. ...
(Date:8/22/2014)... RIVERSIDE, Calif. Thomson Reuters , a leading ... five researchers at the University of California, Riverside in ... brightest minds of our times." , To generate the ... (2002-2012) to identify researchers whose published work has had ... included among some 3,200 individuals who published the greatest ...
(Date:8/22/2014)... Research presented at the 29th Annual International Papillomavirus ... Hera Therapeutics Inc. combats three types of human ... of all cervical cancer. , When tested in ... replication of HPV-16, HPV-18 and HPV-11 cells, according ... Ph.D., who presented the findings at the Seattle ...
Breaking Biology News(10 mins):Biometrics Market in North America 2014-2018: Key Vendors are 3M Cogent, Cross Match, NEC and Safran SA 2Biometrics Market in North America 2014-2018: Key Vendors are 3M Cogent, Cross Match, NEC and Safran SA 35 UC Riverside scientists among world's most influential scientific minds 2
... being launched to try to boost the income of the ... time provide consumers with more nutritious, better tasting food. , ... quality rice varieties that could fetch a higher price from ... , The main aim of the new International Network for ...
... the United States appears to be strongly associated with ... conducted by Paul Winchester, M.D., professor of clinical pediatrics ... his findings May 7 at the Pediatric Academic Societies' ... Society, the Society for Pediatric Research, the Ambulatory Pediatric ...
... Hopkins undergraduates have invented a device to improve cell ... inside a major blood vessel. , A team ... Hopkins doctors and engineers, devised a protective "pouch" that ... the liver. This pouch would keep microcapsules of therapeutic ...
Cached Biology News:New knowledge improves rice quality 2Premature births may be linked to seasonal levels of pesticides and nitrates in surface water 2Students invent protective pouch to enhance cell therapy 2Students invent protective pouch to enhance cell therapy 3Students invent protective pouch to enhance cell therapy 4
(Date:8/21/2014)... Ontotext S4 , The Self Service Semantic ... Now the same enterprise hardened text mining, Linked Data ... is available to start-ups and mid-size businesses at a ... do not have resources to evaluate and prototype enterprise ... there is no need for on premise hardware provisioning ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 On Wednesday of ... gel to use Redox Signaling molecules, became available for purchase ... overwhelming. , "The way that RENU 28 works is, if ... slowing down of the rate of cellular renewal within your ... the increasing of that rate of cellular renewal. What RENU ...
(Date:8/20/2014)... school history lessons often have it that American Indians ... cough, chicken pox, influenza and tuberculosis brought to the ... estimates vary, about 20 million people lived in the ... of them were killed by European diseases., But new ... State University and Johannes Krause of the University of ...
(Date:8/20/2014)... 2014 High performance computing (HPC) ... most complete climate and Earth system model to ... issues. , Eight national laboratories, including Lawrence ... Center for Atmospheric Research, four academic institutions and ... participating national laboratories include Argonne, Brookhaven, Lawrence Berkeley, ...
Breaking Biology Technology:Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 2Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 3Ontotext Releases Text Mining & Semantic Technology Running in the Cloud – Welcome to “S4? 4RENU 28 Skin Care Now Available in Australia and New Zealand 2Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3
... June 6, 2011 Avantra® Biosciences, a leading ... Prototyping Service. Avantra,s new service allows researchers to ... designed biomarker assays developed on Avantra,s proven QPDx™ ... easy-to-use, quantitative multiplex protein assays using catalog or ...
... June 4, 2011 To aid the fight of ... Europe, BGI-Shenzhen and their collaborators at the University Medical ... result built upon the sequencing data previously released and ... one of the first genomes assembled using the latest ...
... FluoroPharma Medical (OTC.BB: FPMI), a biopharmaceutical company ... the change of its official stock ticker symbol from ... with the previously announced FluoroPharma Inc. merger with CEWM. ... is a biopharmaceutical company engaged in the discovery and ...
Cached Biology Technology:Further Analysis on Improved Genome Assembly Indicates the Outbreak E. coli has Complex Genetics With Resistance to at Least Eight Antibiotics 2Further Analysis on Improved Genome Assembly Indicates the Outbreak E. coli has Complex Genetics With Resistance to at Least Eight Antibiotics 3FluoroPharma Medical Announces Stock Ticker Symbol Change 2
Mouse monoclonal antibody to ST8SIA2 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2...
Mouse monoclonal antibody raised against a partial recombinant COG2. NCBI Entrez Gene ID = COG2...
Mouse monoclonal antibody raised against a partial recombinant RAB11B. NCBI Entrez Gene ID = RAB11B...
...
Biology Products: