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Elucidation of the genome for diabetics with DNA chips

rvival. Zinc deficiency is common in developing countries and has been associated with many diseases, including dabetes.

These four genes may account for up to 70% of the hereditary basis of DT2. Several tens of other strong "signals" have also been identified. If confirmed, these signals may complete the diabetic genome map.

This work has predictive value and has potential implications for DT2 prevention and treatment. At a time when the number of diabetics is soaring due to the increasing frequency of early, severe obesity, we need to be able to establish the profile of the young adults most at risk; this would allow personalised preventive strategies to be implemented. Some of the genes identified in this study, including the ZnT8 zinc transporter gene in particular, may be good targets for treatments to combat DT2.

These results from the analysis of very high-density DNA chips ?the first in the world for a common disease like DT2 ?demonstrate the validity of this approach. The method will be made available in France in March 2007, through the CNRS genotyping platform at Lille, largely funded by the Nord-pas-de-Calais Regional Council. These advances should make it possible to unravel genetic predisposition to vascular complications of diabetes and to solve the mysteries shrouding childhood obesity and certain cancers linked to obesity . The work of this French-British-Canadian team was financed principally by the Canadian government and by the province of Quebec. The DNA chips were produced at the genomics centre in Montreal.


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Source:CNRS


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