The authors show that regulation of HIF-1 is required for immune defense against bacterial infection. They also show that bacteria killing is increased under conditions of low oxygen due to HIF-1 upregulation, and that bacterial infection upregulates HIF-1. In fact, upregulation of HIF-1 enhances expression of bactericidal agents and killing of bacteria.
This reveals that a novel approach to treating bacterial infection is by increasing the killing capacity of cells of the innate immune system. In a related commentary, Kol Zarember and Harry Melach write, "By dissecting the role of HIF-1 in innate immune defenses, the study…introduces new targets for therapeutic immunomodulation."
TITLE: HIF-1alpha expression regulates the bactericidal capacity of phagocytes
View the PDF of this article at: https://www.the-jci.org/article.php?id=23865
Title: HIF-1alpha: a master regulator of innate host defenses?
View the PDF of this article at: https://www.the-jci.org/article.php?id=25740