Navigation Links
Eliminating bacterial infections out of thin air

When microorganisms invade the body, immune mechanisms kick in to fight them off. The infected tissues typically show depleted oxygen levels, and a protein called HIF-1 alpha regulates this. Interestingly, the cells responsible for destroying the foreign pathogens are effective in this low-oxygen environment. In a new study appearing in the July 1 print issue of The Journal of Clinical Investigation, Randall Johnson and collegues from UCSD show for the first time that induction of the HIF-1 pathway can act as a "super-antibiotic", accelerating the killing of bacteria in conditions typical of those found during bacterial infection and sepsis.

The authors show that regulation of HIF-1 is required for immune defense against bacterial infection. They also show that bacteria killing is increased under conditions of low oxygen due to HIF-1 upregulation, and that bacterial infection upregulates HIF-1. In fact, upregulation of HIF-1 enhances expression of bactericidal agents and killing of bacteria.

This reveals that a novel approach to treating bacterial infection is by increasing the killing capacity of cells of the innate immune system. In a related commentary, Kol Zarember and Harry Melach write, "By dissecting the role of HIF-1 in innate immune defenses, the study…introduces new targets for therapeutic immunomodulation."

###

TITLE: HIF-1alpha expression regulates the bactericidal capacity of phagocytes

View the PDF of this article at: https://www.the-jci.org/article.php?id=23865

ACCOMPANYING COMMENTARY:

Title: HIF-1alpha: a master regulator of innate host defenses?

View the PDF of this article at: https://www.the-jci.org/article.php?id=25740


'"/>

Source:Journal of Clinical Investigation


Page: 1

Related biology news :

1. Anti-bacterial additive widespread in U.S. waterways
2. A bacterial genome reveals new targets to combat infectious disease
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Scientists discover that host cell lipids facilitate bacterial movement
5. Protein prevents detrimental immune effects of bacterial sepsis
6. Researchers develop new method for facile identification of proteins in bacterial cells
7. A virus-like hitchhiker may trigger bacterial meningitis
8. Using the genomic shortcut to predict bacterial behavior
9. Student scientists create living bacterial photographs
10. Researchers identify molecular anchor that allows bacterial invasion of central nervous system
11. Scientists determine structure of enzyme that disrupts bacterial virulence
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/3/2017)... 3, 2017 Onitor, provider of digital health ... Track, an innovative biometric data-driven program designed to aid ... at the 2017 Consumer Electronics Show (CES) in ... the U.S., the World Health Organization (WHO), have identified ... adults who are overweight or obese. WHO also states ...
(Date:12/22/2016)... YORK , December 22, 2016 ... provider of secure solutions for the e-Government, Public Safety, HealthCare, and ... subsidiary of SuperCom, has been selected to implement and deploy a ... in Northern California , further expanding its presence ... ...
(Date:12/20/2016)... N.C. and GENEVA, Dec, 20, 2016 /PRNewswire/ ... biometric data sensor technology, and STMicroelectronics ... the spectrum of electronics applications, announced today the ... development kit for biometric wearables that includes ST,s ... with Valencell,s Benchmark™ biometric sensor system. ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... 2017 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ) ... agreement with Rodman & Renshaw, a unit of ... running manager and representative of several underwriters, under which the ... basis a minimum of 2,105,264 shares of common stock ... minimum of 1,052,632 shares of common stock of the ...
(Date:1/23/2017)... 23, 2017  Spherix Incorporated (Nasdaq: SPEX ... fostering of technology and monetization of intellectual property, today ... Anthony Hayes , Chief Executive Officer ... continue to communicate with shareholders about the status of ... diligence on other patent assets that fit with our ...
(Date:1/23/2017)... CALGARY , Jan. 23, 2017 /PRNewswire/ - Resverlogix ... preliminary results from the New Zealand ... impaired patients. The data showed remarkable results in reducing ... versus healthy control patients. It is believed that this ... direct connection of this type can be made between ...
(Date:1/23/2017)... ... January 23, 2017 , ... Calvert ... President, Preclinical Safety and Senior Director, Safety Pharmacology. Dr. Thomas earned his ... , Dr. Thomas’ career as an academic and industry preclinical drug developer spans ...
Breaking Biology Technology: