Navigation Links
Eliminate Data Analysis Bottlenecks in Drug Discovery

like its sirtuin relatives, is best known for removing molecular "decorations" on proteins that help organize DNA and restrict access to genes. It turns out that sirtuin1 also removes these decorations from PGC1, and then remains bound to PGC1 as it starts up the sugar-making process, the researchers found.

"Because both proteins are required for the liver to make sugar, targeting sirtuin1 in a very specific way might help control sugar production in people with diabetes," says Puigserver. "Sirtuin1 interacts with many different proteins, and it's just this one interaction you would want to prevent."

But, he says, PGC1 has an unusually close relationship with sirtuin1 that may make for relatively easy picking. PGC1, unlike the vast majority of proteins, only uses sirtuin1 to remove its "decorations," called acetyl groups. Most other proteins can have the groups plucked off by a number of different enzymes.

"PGC1 is a 'clean' target for sirtuin1," says Puigserver. "If sirtuin1 isn't available, PGC1 becomes covered in acetyl groups, and the acetyl-covered PGC1 can't make sugar."

In their experiments, graduate student Joseph Rodgers also discovered that the livers of fasted mice first developed high levels of a chemical called pyruvate, which is a starting material for making glucose, and then accumulated high levels of sirtuin1 protein. (Rodgers will receive the Nupur Dinesh Thekdi Research Award on April 14 for this work as part of the School of Medicine's 28th annual Young Investigators' Day celebration.)

"When there's no incoming food, muscles make lactate and alanine and send them to the liver to be converted into pyruvate and glucose," says Puigserver. "It appears, from our work, as though the pyruvate then triggers increased production of sirtuin1, which in turn lets PGC1 start converting the pyruvate into the glucose the body needs to survive."

The relationship between sirtuin1 and PGC1 also connects processes in
'"/>

Source:


Page: 1 2 3

Related biology news :

1. Ariadne Genomics Announces the Release of PathwayStudio?Central, Client-Server Software for Biological Pathway Analysis
2. Analysis Of Human Genome To Predict The Development Of Illnesses
3. Analysis of flower genes reveals the fate of an ancient gene duplication
4. Genomatix Microarray Analysis Pipeline achieves Affymetrix GeneChip compatible?status
5. Analysis of breast-cancer gene role offers promising target
6. Analysis of rhesus monkey genome uncovers genetic differences with humans, chimps
7. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Eliminate Data Analysis Bottlenecks Drug Discovery

(Date:9/15/2014)... results will allow us to better understand how ... change scenarios and provide the type of environmental ... management and siting of protected areas," said Paula ... for Coastal Ocean Science (NCCOS) and lead author ... lie within the temperate-tropical transition zone, where historically, ...
(Date:9/15/2014)... Schmid, an assistant professor in the Department of Science ... Arts and Human Sciences at Virginia Tech, has won ... Award to study the prospects and problems of creating ... failure of Japan,s Fukushima I Nuclear Power Plant in ... scientific community viewed nuclear emergencies, Schmid said. Three of ...
(Date:9/15/2014)... lifeplants and animalsto thrive in the oceans, there ... In certain coastal areas, extreme oxygen-starvation produces "dead ... web structure. As dissolved oxygen levels decline, energy ... microbial community metabolism resulting in impacts on the ... the past 50 years, oxygen minimum zones (OMZs) ...
Breaking Biology News(10 mins):Study finds warming Atlantic temperatures could increase range of invasive species 2'Nuclear disasters don't respect national boundaries' 2Decoding virus-host interactions in the oxygen-starved ocean 2Decoding virus-host interactions in the oxygen-starved ocean 3Decoding virus-host interactions in the oxygen-starved ocean 4Decoding virus-host interactions in the oxygen-starved ocean 5
... Ireland Cancer Center of University Hospitals Case Medical Center ... breast cancers express the MUC-1 target. This first-of-its-kind finding, ... has paved the way for an upcoming vaccine trial ... that could potentially prevent recurrence of this aggressive type ...
... from the effects of acid rain, as wet weather counteracts ... The research, by Professor Steve Ormerod and Dr Isabelle Durance ... year period around Llyn Brianne in mid-Wales. Their findings are ... of Applied Ecology . Carried out in 14 streams, ...
... PULLAUP, WA This Christmas season, think twice about ... Christmas tree. The good, old-fashioned methodkeeping your tree in ... to keep your tree green and healthy. Researchers have ... Christmas trees; in fact, in several cases the chemical ...
Cached Biology News:Ireland Cancer Center researcher finds most triple-negative breast cancers express muc-1 target 2Climate-change set-back for acidified rivers 2Flame retardants prove ineffective on fresh-cut Christmas trees 2
(Date:9/15/2014)... by Northeastern University has developed a novel method ... variety of nanocarbon structures in carbon nanotube arrays. ... will allow the researchers to tailor the physical ... ranging from electronic devices to CNT-reinforced composite materials ... , Their findings were published in the journal ...
(Date:9/15/2014)... The chemistry, taste, and health effects of tea ... published by the nonprofit American Botanical Council (ABC). Recent research ... its effects on the phytochemical compounds in tea ( Camellia ... Dr. Ahmed in the Yunnan province ... for the future of medicinal botanicals. Dr. Ahmed,s report ...
(Date:9/15/2014)... , Sept. 15, 2014  The second annual ... October 12-18. A joint initiative of the Plasma ... companies , IPAW is designed to: , ... Recognize the contributions of plasma donors in saving and ... protein therapies and rare diseases Member ...
(Date:9/13/2014)... September 13, 2014 Boehringer Laboratories Inc., ... is proud to announce the successful broadcast of a ... surgeons Leonardo Claros, MD, FACS, FAMBS, and Maher El ... Gastrectomy Calibration System. , This sleeve gastrectomy surgery ... of more than four hundred surgeons from around the ...
Breaking Biology Technology:Northeastern University Researchers Develop Novel Method for Working with Nanotubes 2Tea Taste and Quality Affected by Climate Change 2Tea Taste and Quality Affected by Climate Change 3Tea Taste and Quality Affected by Climate Change 4International Plasma Awareness Week To Celebrate Donors And Spotlight Rare Diseases 2International Plasma Awareness Week To Celebrate Donors And Spotlight Rare Diseases 3Boehringer Laboratories, Inc. Announces Live Surgery Using Innovative System to Calibrate Sleeve Gastrectomy 2
... N.J., May 30, 2012  Today, leading events organizer ... to showcase the latest developments and opportunities across a ... by the same team as InformexUSA, North America,s leading ... chemistry, and managed in conjunction with the UBM team ...
... California Institute for Nursing & Health Care (CINHC) released ... pilot New Graduate Nurse Transition to Practice Programs (RN ... San Francisco, found that the programs are making a ... graduates and increasing their employment opportunities in hospitals and ...
... 2012 Sequenom, Inc. (NASDAQ: SQNM ), a ... the Company,s participation at the Jefferies 2012 Global Healthcare Conference ... 4-7, 2012. Harry F. Hixson, Jr., Ph.D., ... beginning at 11:00 a.m. ET, to provide an overview of ...
Cached Biology Technology:Informex Returns To India In 2012 2Informex Returns To India In 2012 3Study Shows Transition to Practice Programs Get Nurses Employed 2
... locus encodes two unrelated proteins both of ... the cell cycle in a p53-dependent manner. ... rapid degradation of mdm2 proteinrequired for mdm2 ... This interaction is mediated by the ...
human Exodus-2 Research Focus: cytokine/growth factor Storage Temperature: -20C Shipping Temperature: 4C...
...
Gel Loading Buffer contains a precipitant to ensure that the samples sink into the wells and a tracking dye to allow the user to follow the progress of electrophoresis....
Biology Products: