Navigation Links
Eleven gene 'signature' reliably predicts cancer prognosis

The rather new concept of "tumor stem cells" maintains that a rare, stem cell-like population of cancer cells exists among the mix of other cells found in a tumor and that these tumor stem cells are responsible for tumor progression and metastasis. In a revolutionary study appearing in the June 1 print issue of The Journal of Clinical Investigation, Gennadi Glinsky and colleagues from the Sidney Kimmel Cancer Center evaluated 1122 cancer patients diagnosed with 10 different types of cancer.

The researchers used genetic approaches to identify an 11-gene BMI-1-pathway signature, which determines normal stem cell proliferation and which also consistently displays a stem cell-like expression profile in metastatic tumors in a mouse cancer model as well as metastatic tumors from prostate cancer patients. The results show that a stem cell-like expression profile of the 11-gene signature in primary tumors is a very consistent and powerful predictor of a short interval to disease recurrence, metastasis, and death after therapy in cancer patients diagnosed with ten distinct types of cancer.

This work indicates that the presence of the conserved BMI-1-associated gene expression pathway that exists in a very malignant subset of human cancers predicts a marked predisposition toward metastasis and a high probability of poor therapy outcome. In an accompanying commentary, Gordon Mills and others write, "such a "magic marker" [will] have a major impact on patient care."

TITLE: Microarray analysis identifies a death from cancer signature predicting therapy failure in patients with multiple types of cancer


'"/>

Source:Journal of Clinical Investigation


Page: 1

Related biology news :

1. Common molecular signature identified in solid tumors
2. Novel molecular signature marks DNA of embryonic stem cells
3. Common molecular signature identified in solid tumors
4. Molecular signature protects cells from viruses
5. Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia
6. Ocean climate predicts elk population in Canadian Rockies
7. Identification of specific genes predicts which patients will respond to Hepatitis C treatment
8. Rensselaer researchers develop approach that predicts protein separation behavior
9. Sweet water taste paradoxically predicts sweet taste inhibitors
10. Signature of chromosome instability predicts cancer outcomes
11. Blood test predicts success of quitting smoking using the nicotine patch
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Eleven gene signature reliably predicts cancer prognosis

(Date:8/27/2014)... is a dreaded bacterium that can be found in ... weeks, 28 persons in Denmark have been infected with ... 13 have died. , The bacterium is notoriously difficult ... to adapt to changes in its surroundings, says Associate ... colleagues from the Department of Biochemistry and Molecular Biology, ...
(Date:8/26/2014)... have developed algorithms to identify weak spots in tendons, ... technology, which needs to be refined before it is ... strains and tiny injuries in the body,s tissues long ... online Aug. 27 in the Journal of the ... nexus of the physical and life sciences. , "Tendons ...
(Date:8/26/2014)... in obtaining an unprecedented view of a type ... range of neurological illnesses, including Alzheimer,s disease, Parkinson,s ... with stroke. , The team of biologists at ... of Energy,s Advanced Photon Source at Argonne National ... intact NMDA (N-methyl, D-aspartate) receptor should serve as ...
Breaking Biology News(10 mins):Researchers discover why Listeria bacterium is so hard to fight 2Researchers discover why Listeria bacterium is so hard to fight 3New technology may identify tiny strains in body tissues before injuries occur 2New technology may identify tiny strains in body tissues before injuries occur 3Unprecedented detail of intact neuronal receptor offers blueprint for drug developers 2Unprecedented detail of intact neuronal receptor offers blueprint for drug developers 3
... that shifts the body's fuel consumption from glucose to fat ... team led by scientists at The University of Texas Medical ... Nature. , While their findings could provide new ... signal that emerged from the dark also presents a new ...
... newly identified human bocavirus was found in nearly 5 ... very young children. Researchers from the Centers for ... the International Conference on Emerging Infectious Diseases , "Our ... with pneumonia in Thailand, especially among young children," says ...
... Institute of Allergy and Infectious Diseases (NIAID), part of ... defect in the immune response of people with the ... of developing serious complications following smallpox vaccination. Led by ... Medical and Research Center in Denver, the researchers used ...
Cached Biology News:Darkness unveils vital metabolic fuel switch between sugar and fat 2Darkness unveils vital metabolic fuel switch between sugar and fat 3Bocavirus infection may be associated with pneumonia in Thailand, especially in children 2Defective immune system response to smallpox vaccine detailed in new study 2Defective immune system response to smallpox vaccine detailed in new study 3
(Date:8/27/2014)... plants survive impact by the huge amounts of ... this energy for photosynthesis. The hypothesis is that ... dissipate the energy throughout the entire protein molecule ... have now managed to successfully ,film, this process. ... proteins which play a role in photosynthesis and ...
(Date:8/27/2014)... , Aug. 27, 2014 ... the "Global Lactic Acid  (Biodegradable Polymer, Food ... Trends & Forecasts to 2019" report to ... simplest hydroxyl-carboxylic acid with an asymmetrical carbon atom. ... the biodegradable polymer, food and beverage, personal care ...
(Date:8/27/2014)... “We are honored to be named ... Thangaraj, CEO of Radiant Sage. “We are offering truly ... imaging corelab market to a different level. We ... to efficiently and effectively manage the massive amounts of ... analyzed and read by trained physicians. Being recognized by ...
(Date:8/27/2014)... 27, 2014 Flagship Biosciences LLC, a ... to the pharmaceutical and medical device industries, has announced ... fast growing company has consolidated its histology and tissue ... to Westminster, CO, just north of Denver. The ... W. 103rd Ave., Suite 100, Westminster, CO 80021 , ...
Breaking Biology Technology:DTU researchers film protein quake for the first time 2Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2Flagship Biosciences Announces Relocation and Expansion 2
... Host Conference Call Today at 5:00 p.m., CAMBRIDGE, ... announced today that the FDA has informed the,company of ... bioreactor scale and Myozyme produced at the 2000L scale ... in the,carbohydrate structures of the molecules. Currently, Genzyme has ...
... at DiscoverTesting.com, Test Kit Developed in Response to ... Consumer Demand for ... Research unveils,its newest Watersafe product this week, addressing consumer concerns,regarding ... Test Kit tests for ten contaminants with easy-to-use,at-home results, most ...
... ATLANTA, April 21 Biofisica Inc., an Atlanta-based,company ... it has,obtained a commitment of $2.3 million in ... marketing efforts in the UK and,ongoing planning initiatives ... ), The round was led by Unilever ...
Cached Biology Technology:Genzyme Provides Update on Myozyme(R) Manufacturing 2Genzyme Provides Update on Myozyme(R) Manufacturing 3Genzyme Provides Update on Myozyme(R) Manufacturing 4Genzyme Provides Update on Myozyme(R) Manufacturing 5Silver Lake Research Unveils Watersafe(R) Well Water Test Kit 2Biofisica Obtains $2.3 Million in Financing From Investors 2
... System - dCTP with CyScribe GFX ... generation and purification of Cy3- and ... for complete cDNA labeling and purification.Flexible ... for performing labeling reactions with either ...
Canine Serum...
UV-NIR light source for USB2000, HR4000, HR2000+...
... EPS 1001 Power Supply, 1. ... maximum.Constant voltage, constant current, and constant ... read-outs for precision and reproducibility.Stores and ... ultrathin flatbed gels on Multiphor ...
Biology Products: