Navigation Links
Eleven gene 'signature' reliably predicts cancer prognosis

The rather new concept of "tumor stem cells" maintains that a rare, stem cell-like population of cancer cells exists among the mix of other cells found in a tumor and that these tumor stem cells are responsible for tumor progression and metastasis. In a revolutionary study appearing in the June 1 print issue of The Journal of Clinical Investigation, Gennadi Glinsky and colleagues from the Sidney Kimmel Cancer Center evaluated 1122 cancer patients diagnosed with 10 different types of cancer.

The researchers used genetic approaches to identify an 11-gene BMI-1-pathway signature, which determines normal stem cell proliferation and which also consistently displays a stem cell-like expression profile in metastatic tumors in a mouse cancer model as well as metastatic tumors from prostate cancer patients. The results show that a stem cell-like expression profile of the 11-gene signature in primary tumors is a very consistent and powerful predictor of a short interval to disease recurrence, metastasis, and death after therapy in cancer patients diagnosed with ten distinct types of cancer.

This work indicates that the presence of the conserved BMI-1-associated gene expression pathway that exists in a very malignant subset of human cancers predicts a marked predisposition toward metastasis and a high probability of poor therapy outcome. In an accompanying commentary, Gordon Mills and others write, "such a "magic marker" [will] have a major impact on patient care."

TITLE: Microarray analysis identifies a death from cancer signature predicting therapy failure in patients with multiple types of cancer


'"/>

Source:Journal of Clinical Investigation


Page: 1

Related biology news :

1. Common molecular signature identified in solid tumors
2. Novel molecular signature marks DNA of embryonic stem cells
3. Common molecular signature identified in solid tumors
4. Molecular signature protects cells from viruses
5. Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia
6. Ocean climate predicts elk population in Canadian Rockies
7. Identification of specific genes predicts which patients will respond to Hepatitis C treatment
8. Rensselaer researchers develop approach that predicts protein separation behavior
9. Sweet water taste paradoxically predicts sweet taste inhibitors
10. Signature of chromosome instability predicts cancer outcomes
11. Blood test predicts success of quitting smoking using the nicotine patch
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... ITHACA, N.Y. , June 23, 2017 ... a leader in dairy research, today announced a new ... help reduce the chances that the global milk supply ... this dairy project, Cornell University has become the newest ... Food Supply Chain, a food safety initiative that includes ...
(Date:6/14/2017)... IBM ) is introducing several innovative partner startups at ... between startups and global businesses, taking place in ... startups will showcase the solutions they have built with IBM ... France is one of the most ... increase in the number of startups created between 2012 and ...
(Date:5/23/2017)... , May 23, 2017  Hunova, the first robotic gym for the ... been officially launched in Genoa, Italy . The first ... and the USA . The technology was developed ... market by the IIT spin-off Movendo Technology thanks to a 10 million ... News Release, please click: ...
Breaking Biology News(10 mins):
(Date:6/20/2017)... , ... June 20, 2017 , ... Do More with ... transition from being a trusted supplier in the weighing industry, to extending its expertise ... ELISA essays, enzyme reactions, immunoassays, hybridizations and more, allowing for its customers ...
(Date:6/19/2017)... PA (PRWEB) , ... June 19, 2017 , ... ... companies for over 50 years. One of the biggest challenges faced by life sciences, ... firm’s regulatory affairs services team is Kati Abraham , who is well known ...
(Date:6/16/2017)... ... ... CTNext , Connecticut’s go-to resource for entrepreneurial support, today announced the ... Piers in Stamford. , Nine finalists, all of whom are Connecticut-based companies and entrepreneurs, ... secure $10,000 awards to help support business growth. The winners included:, ...
(Date:6/15/2017)... ... June 15, 2017 , ... ... new medical device startup. Dan Parsley, angelMD’s SVP of Corporate Development, served as ... this angelMD syndicate is part of Saranas’ recently announced $4 million Series B ...
Breaking Biology Technology: