Navigation Links
Elevated temperature enhances success of viral cancer therapy

A therapeutic approach for battling cancer that is based on infection with a specially designed virus similar to the one that causes the common cold has shown promise in clinical trials. Now, new research suggests that fever might be a useful weapon in the fight as well. The study, published in the July issue of Cancer Cell, demonstrates that tumor cells are even more sensitive to viral therapy after they have been incubated at an elevated temperature. The findings could have a significant impact on the future success of viral strategies for cancer therapy.

ONYX-015 is a mutated adenovirus that undergoes selective replication in tumor cells until the cells become so full of virus that they burst and die. The virus is modified so that it only copies itself in tumor cells and is safe for normal cells. In clinical trials, ONYX-015 was a successful therapy for many cancer patients, but the success varied considerably for reasons that were not well understood. Dr. Clodagh C. O'Shea and colleagues from the Cancer Research Institute at the University of California, San Francisco examined why ONYX-015 did not undergo replication in some cancer cells and if it might be possible to sensitize tumor cells to ONYX-015 therapy.

The researchers demonstrated that resistant tumor cells fail to complete an RNA export function that is necessary for ONYX-015 replication. Interestingly, when a cellular heat shock response was induced in the resistant tumor cells, either pharmacologically or by incubating the cells at an elevated temperature similar to that experienced by humans when they have a fever, the RNA export function was restored. Therefore, induction of the heat shock response could rescue ONYX-015 replication in resistant tumor cells.

According to Dr. O'Shea, "Our data suggest that a clinical strategy that does not advocate the use of pharmacological agents to suppress fever would favor the tumor-selective replication of ONYX-015. This study indicates th
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Climate model links higher temperatures to prehistoric extinction
2. Taking evolutions temperature: Researchers pinpoint the energy it takes to make a species
3. Ocean temperature predicts spread of marine species
4. Rising ocean temperatures, pollution have oysters in hot water
5. Healthy coral reefs hit hard by warmer temperatures
6. Pulsating ultrasound enhances gene therapy for tumors
7. NYU algorithm enhances ability to detect cancer genes
8. Proteasome activator enhances survival of Huntingtons disease neuronal model cells
9. New, automated tool successfully classifies and relates proteins in unprecedented way
10. Biomarkers isolated from saliva successfully predict oral and breast cancer
11. Secret of smallpoxs success may lead to bioterror cure
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Elevated temperature enhances success viral cancer therapy

(Date:8/21/2014)... scientists including researchers from the University of Georgia recently published ... the journal Science . Their discovery paves the way ... in farming and industry. , Canola is grown across ... crop is increasingly cultivated in Georgia. Canola oil used for ... fat and rich supply of omega-3 fatty acids, but the ...
(Date:8/21/2014)... in smog-producing toxins in past decade, GTA still ... shows that while the Greater Toronto Area (GTA) ... contribute to smog, the city continues to violate ... which can cause or aggravate health problems such ... by a set of complex photochemical reactions involving ...
(Date:8/21/2014)... of American singles found that during sex with ... rates. On average, men experience orgasm 85.1 percent ... little difference. For women, however, orgasm occurrence is ... percent of the time during sex with a ... women,s sexual orientation, with lesbian women experiencing orgasm ...
Breaking Biology News(10 mins):Canola genome sequence reveals evolutionary 'love triangle' 2Despite a significant reduction in smog-producing toxins, the Greater Toronto Area still violates Canada's standards for ozone air pollution 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4
... and evolution of every living organism. In plants, the general ... growing down, into the soil, and their stems respond negatively, ... plants sense gravity and how do they direct or signal ... botanists understand a great deal about how this works, a ...
... Educational Research Association (AERA) is proud to announce the ... Education, a volume aimed at educators, researchers, policy makers, ... issues. This book is published by Routledge Publishers on ... on environmental education could not come at a better ...
... Bethesda, MD The Federation of American Societies ... registration for the Science Research Conference (SRC): Genetic ... Science Research Conference on Genetic Recombination & Genome ... and representing all leading model systems in the ...
Cached Biology News:How plants sense gravity -- a new look at the roles of genetics and the cytoskeleton 2How plants sense gravity -- a new look at the roles of genetics and the cytoskeleton 3AERA announces publication of the 'International Handbook of Research on Environmental Education' 2
(Date:8/20/2014)... 20, 2014 Clintrax Global, Inc., a ... Raleigh, NC , recently announced ... Vice President of Administration. As ... corporate processes, including their alignment with company objectives ... worked as an HR executive, specializing in needs ...
(Date:8/20/2014)... often have it that American Indians largely were wiped ... influenza and tuberculosis brought to the New World by ... 20 million people lived in the Americas shortly before ... killed by European diseases., But new research led by ... Johannes Krause of the University of Tubingen in Germany ...
(Date:8/20/2014)... , Aug. 20, 2014 Neurotrope, ... host a conference call to provide an update ... p.m. Eastern daylight timeDial-in numbers:(888) 505-4369 (U.S. and ... Live web cast: www.neurotropebioscience.com , under "Investor Relations"The ... after completion through September 2, 2014 at (888) ...
(Date:8/20/2014)... , Aug. 20, 2014  Decision Resources Group finds that the ... Russia , India and ... in 2013, roughly equal to the size of the ... BRIC market will experience much faster growth as a result of ... Other key findings from Decision Resources Group,s coverage of ...
Breaking Biology Technology:Clintrax Global, Inc. Announces Addition to Executive Team 2Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3Neurotrope To Host Conference Call 2BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 2BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 3
... GlaxoSmithKline plc (LSE/NYSE: GSK ) announced ... its wholly-owned subsidiary Gemstone Acquisition Corporation for shares of ... GNLB ). The tender offer expired at 12:00 midnight, ... depositary for the tender offer has advised GSK that ...
... 7 Intradigm Corporation, a leading,developer of targeted, ... company has closed the final tranche of its ... million tranche, with,existing investor, Lilly Ventures, also participating. ... Series B financing to $21.4 million. Intradigm ...
... 7 Cell Therapeutics, Inc. (CTI),(Nasdaq and MTA: CTIC) ... Listing Qualifications Panel has granted CTI,s request to transfer,the ... Market to The NASDAQ,Capital Market, which will be effective ... CTI,s shares will continue to trade under the ticker ...
Cached Biology Technology:GlaxoSmithKline Successfully Completes Tender Offer for Shares of Genelabs Technologies, Inc. 2Intradigm Closes Final Tranche of $21.4 Million Series B Financing 2Intradigm Closes Final Tranche of $21.4 Million Series B Financing 3Cell Therapeutics Announces Receipt of NASDAQ Panel Decision to Transfer to NASDAQ Capital Market 2Cell Therapeutics Announces Receipt of NASDAQ Panel Decision to Transfer to NASDAQ Capital Market 3
... General description: self locking design in ... a new product number, created to ... showing no availability yet, please order ... or contact customer service for assistance. ...
... Arabidopsis 2 Oligo Microarray Kit (V2), 22K is ... and stress response. Each microarray contains content derived ... Institute for Genomic Research (TIGR) and represents 21,500 ... 5 standard 1 x 3? glass slides each ...
... of poor quality running into billions ... are under increasing pressure to reduce ... the microscopic distribution of ingredients is ... such as dissolution, stability, bio-availability and ...
... allows a rapid and efficient immunoprecipitation ... protein. The immunoprecipitation is performed with ... highly specific monoclonal antibody covalently attached ... affinity resin allows an efficient binding ...
Biology Products: