Navigation Links
Elevated temperature enhances success of viral cancer therapy

A therapeutic approach for battling cancer that is based on infection with a specially designed virus similar to the one that causes the common cold has shown promise in clinical trials. Now, new research suggests that fever might be a useful weapon in the fight as well. The study, published in the July issue of Cancer Cell, demonstrates that tumor cells are even more sensitive to viral therapy after they have been incubated at an elevated temperature. The findings could have a significant impact on the future success of viral strategies for cancer therapy.

ONYX-015 is a mutated adenovirus that undergoes selective replication in tumor cells until the cells become so full of virus that they burst and die. The virus is modified so that it only copies itself in tumor cells and is safe for normal cells. In clinical trials, ONYX-015 was a successful therapy for many cancer patients, but the success varied considerably for reasons that were not well understood. Dr. Clodagh C. O'Shea and colleagues from the Cancer Research Institute at the University of California, San Francisco examined why ONYX-015 did not undergo replication in some cancer cells and if it might be possible to sensitize tumor cells to ONYX-015 therapy.

The researchers demonstrated that resistant tumor cells fail to complete an RNA export function that is necessary for ONYX-015 replication. Interestingly, when a cellular heat shock response was induced in the resistant tumor cells, either pharmacologically or by incubating the cells at an elevated temperature similar to that experienced by humans when they have a fever, the RNA export function was restored. Therefore, induction of the heat shock response could rescue ONYX-015 replication in resistant tumor cells.

According to Dr. O'Shea, "Our data suggest that a clinical strategy that does not advocate the use of pharmacological agents to suppress fever would favor the tumor-selective replication of ONYX-015. This study indicates th
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Climate model links higher temperatures to prehistoric extinction
2. Taking evolutions temperature: Researchers pinpoint the energy it takes to make a species
3. Ocean temperature predicts spread of marine species
4. Rising ocean temperatures, pollution have oysters in hot water
5. Healthy coral reefs hit hard by warmer temperatures
6. Pulsating ultrasound enhances gene therapy for tumors
7. NYU algorithm enhances ability to detect cancer genes
8. Proteasome activator enhances survival of Huntingtons disease neuronal model cells
9. New, automated tool successfully classifies and relates proteins in unprecedented way
10. Biomarkers isolated from saliva successfully predict oral and breast cancer
11. Secret of smallpoxs success may lead to bioterror cure
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Elevated temperature enhances success viral cancer therapy

(Date:5/7/2015)... 7, 2015 Fingerprint Cards ... and FPC1035, FPC,s smallest touch fingerprint sensors to ... considered for integration on the backside of the ... increased possibilities to integrate touch fingerprint sensors in ... improves possibilities for module manufacturers to customize the ...
(Date:4/27/2015)... , Apr. 27, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, ... to pre-order customers the first week of May, 2015 ... month of May. Gino Pereira ... milestone for the company as Wocket® enters the consumer ...
(Date:4/20/2015)... 20, 2015 The announcement comes ... Glenbeigh Records Management (GRM), Ireland,s foremost ... Bank. Having built up an impressive track record of clients ... player within the records management sector in Dubai ... is GCC staffbase and employ a further eight staff members ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... CA--In the coastal valleys of central California, where more ... grown, there is developing concern about the impact of ... a study published in the August 2013 issue of ... the introduction of new cultivars has increased strawberry yields ...
... is available in German . ... in the future energy mix for Germany. Up until now ... These were the conclusions of a study conducted by the TLL ... and the Helmholtz Center for Environmental Research (UFZ). According to ...
... inhabits the high-traffic waters near the Three Gorges Dam ... animals alive today. Scientists from Woods Hole Oceanographic Institution ... to shed new light on this species, critical sense ... dredging, and underwater construction. "We want to understand ...
Cached Biology News:New research informs California strawberry production practices 2The potential of straw for the energy mix has been underestimated 2The potential of straw for the energy mix has been underestimated 3Seeing in the dark 2Seeing in the dark 3
(Date:5/22/2015)... May 22, 2015 Baylor Research Institute (BRI) ... Translational Genomics Research Institute (TGen) in Phoenix, ... on accelerating early detection and treatments for patients with a ... institutions will lead to new clinical trials and access to ... the gap from bench to bedside across Baylor Scott ...
(Date:5/21/2015)... -- Prima Biomed Ltd. (NASDAQ: PBMD ) a globally ... leader in the development of immunotherapeutic products for the ... data from the Phase II CAN-003 ovarian cancer clinical ... meaningful improvement in Overall Survival ("OS") over standard of ... the group of second remission patients (n=20), the median ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 Patent Offering, ... method for diagnostic or therapeutic imaging within a body ... uses an endoscope having a low cost, single-use disposable ... filing date was October 18, 2013 and the patent ... technology enables the physician to customize the lighting and ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 Veolia’s ... an exclusive North American distribution agreement with VWR ... system. , With more than 160 years of ... and services for laboratory and production facilities, has ... excellence and differentiated services to enable science. ...
Breaking Biology Technology:Precision Medicine Collaboration to Increase Options for Cancer Patients 2Precision Medicine Collaboration to Increase Options for Cancer Patients 3Precision Medicine Collaboration to Increase Options for Cancer Patients 4Correction Continues after Big Move - BrokerBank Securities, Inc. 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3Veolia’s TECTA™ B16 Instrument for E. Coli Detection is Offered Exclusively Through VWR 2
... of Origin Test Aids in the Diagnosis of Uncertain ... ... Calif., April 22 Pathwork Diagnostics, Inc.,a genomics-based diagnostics company focused ... Test through its CLIA-certified,Pathwork(R) Diagnostics Laboratory. The new test aids in ...
... Responsible Site to Significantly Increase Company,s ... Presence ... GENZ ) announced today that it will build a major new ... in,Genzyme,s ongoing global expansion and commitment to establishing a,long-term presence in ...
... Kingdom Needs to Wake Up to Threat of Bioterrorism, Says UK ... ... the only company in,the world to develop and deploy technology that ... the tainted,materials, today announced it has partnered with General Lord Guthrie,former ...
Cached Biology Technology:Pathwork(R) Diagnostics Launches Genomics-Based Test For Hard-To-Identify Tumors Through Its CLIA-Certified Laboratory 2Pathwork(R) Diagnostics Launches Genomics-Based Test For Hard-To-Identify Tumors Through Its CLIA-Certified Laboratory 3Genzyme to Build New R&D Center in Beijing 2Genzyme to Build New R&D Center in Beijing 3Genzyme to Build New R&D Center in Beijing 4Genzyme to Build New R&D Center in Beijing 5Boston-Based BioDefense Corp. Announces New UK Partnership to Expand Markets for Biohazard Protection 2Boston-Based BioDefense Corp. Announces New UK Partnership to Expand Markets for Biohazard Protection 3
XPC Immunogen: XPC (NP_004619, 141 a.a. ~ 251 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Rabbit polyclonal to Lck (phospho Y192) ( Abpromise for all tested applications). entrezGeneID: 3932 SwissProtID: P06239...
Anti 7H6 Antigen (tight-junction associated protein Antigen) Monoclonal Antibody 7H6...
Goat polyclonal to Ephrin B2 ( Abpromise for all tested applications). entrezGeneID: 1948 SwissProtID: P52799...
Biology Products: