Navigation Links
Elderly mice yield clues to the process of growing old

Delving deep into the molecular subtleties of a strain of mice engineered to age rapidly, scientists have found that an accumulation of genetic mutations prompts a cascade of programmed cell death that seems to underpin the aging process.

Writing today (July 15, 2005) in the journal Science, a team of scientists led by University of Wisconsin-Madison geneticist Tomas A. Prolla describes a series of experiments in mutant and normal mice that peel away some of the root secrets of mammalian aging.

Growing old, according to the new study, occurs, in part, as mutations build up in the DNA of energy-generating mitochondria, triggering the death of critical cells that lead to such things as hair and weight loss, hearing and vision impairment, loss of muscle mass, weakened bones and fewer circulating red blood cells. Mitochondria are structures within cells that provide energy for cells to move, divide, contract and secrete products vital for the health of organisms.

"We think that the key to what is happening in aging is that as (genetic) mutations or DNA damage accumulates, critical cells die," says Prolla. "These experiments favor a major role for programmed cell death in aging."

If true, the new insights may one day lead to opportunities to stave off old age through drugs that could prevent the gathering of genetic defects in mitochondrial DNA, genetic material that resides outside of the nucleus of a cell and that helps power critical cell processes.

Such insight could also lead to strategies to restore some functions such as hearing by protecting mitochondrial DNA from naturally occurring mutations.

Using mice genetically altered to have a deficiency in a protein that proofreads mitochondrial DNA and thus accumulate genetic mutations at a higher rate than unaltered mice, the group led by Prolla found evidence that programmed cell death, known as apoptosis, was greatly accelerated. The altered mice exhibited obvious hallma
'"/>

Source:University of Wisconsin-Madison


Page: 1 2 3

Related biology news :

1. FDA Warns About Antipsychotic Drugs and Elderly
2. Elderly spinal cord injuries increase five-fold in 30 years, Jefferson neurosurgeons find
3. Genome-wide mouse study yields link to human leukemia
4. Microbial fuel cell: High yield hydrogen source and wastewater cleaner
5. Insight into DNAs weakest links may yield clues to cancer biology
6. Marine sponge yields nanoscale secrets
7. New understanding of cell movement may yield ways to brake cancers spread
8. Small worm yields big clue on muscle receptor action
9. Modified collagen could yield important medical applications
10. Organic farms produce same yields as conventional farms
11. Weight control protein may yield antiobesity drugs
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Elderly mice yield clues the process growing old

(Date:8/22/2014)... first comprehensive study of captive black rhino reproduction ... the success of breeding programmes. , Researchers from ... University of Liverpool carried out a six-year study ... rhino. , Dr Katie Edwards led the research ... of Liverpool. She says: "Although some black rhinoceros ...
(Date:8/22/2014)... 2015, American consumers will finally be able to purchase ... touted as zero-emissions vehicles, most of the cars will ... fuel that contributes to global warming. , Now scientists ... that uses an ordinary AAA battery to produce hydrogen ... current through two electrodes that split liquid water into ...
(Date:8/21/2014)... toxins in past decade, GTA still violates Canada,s ... while the Greater Toronto Area (GTA) has significantly ... smog, the city continues to violate the Canada-wide ... cause or aggravate health problems such as asthma, ... set of complex photochemical reactions involving volatile organic ...
Breaking Biology News(10 mins):Hormone analysis helps identify horny rhinos 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 3Despite a significant reduction in smog-producing toxins, the Greater Toronto Area still violates Canada's standards for ozone air pollution 2
... Fourth Biennial Review, 2012 -- a new congressionally mandated ... in the Comprehensive Everglades Restoration Plan (CERP), a multibillion-dollar, ... the ecosystem,s decline while meeting growing demands for clean ... evaluation of CERP, which was launched in 2000 by ...
... in cellular DNA can trigger tumorigenesis. Researchers from ... structure of a protein involved in the repair ... throws new light on the origins of neurodegenerative ... as radiation or environmental toxins can cause double-stranded ...
... Digicel Pacific Limited, a mobile network operator across the Pacific ... deploying biometric enabled payment systems into stores in New Zealand ... way to send money home to the Pacific. ... register just once and record their fingerprint as permanent identification ...
Cached Biology News:Digicel Launches World's First Biometric Identification System For International Money Transfers 2Digicel Launches World's First Biometric Identification System For International Money Transfers 3
(Date:8/21/2014)... August 21, 2014 On Wednesday of last ... to use Redox Signaling molecules, became available for purchase in ... , "The way that RENU 28 works is, if you ... down of the rate of cellular renewal within your body. ... increasing of that rate of cellular renewal. What RENU 28 ...
(Date:8/20/2014)... history lessons often have it that American Indians largely ... chicken pox, influenza and tuberculosis brought to the New ... vary, about 20 million people lived in the Americas ... them were killed by European diseases., But new research ... University and Johannes Krause of the University of Tubingen ...
(Date:8/20/2014)... California (PRWEB) August 20, 2014 ... develop and apply the most complete climate and ... and demanding climate change issues. , Eight national ... forces with the National Center for Atmospheric Research, ... the new effort. Other participating national laboratories include ...
(Date:8/20/2014)... 2014 The 6th Annual Arrowhead ... on October 29-30 in San Francisco, CA. This year’s ... government researchers and clinicians focused on addressing and solving ... In the twelve years since the sequencing of the ... introduced with pharmacogenetic information in the label and molecular ...
Breaking Biology Technology:RENU 28 Skin Care Now Available in Australia and New Zealand 2Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 36th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2
... COLOGNE, Germany and ... has opened its seventh laboratory worldwide in Electronics City in,the ... and systems. The world,leader in independent safety and quality testing ... new solar test centre, which in particular will,offer services to ...
... team based at the University of Pittsburgh has received ... of Defense to tackle some of the most significant ... that could solve problems too complex for all of ... the Universe to crack. The project was one of ...
... AVANIR Pharmaceuticals, Inc. (Nasdaq: ... Annual Canaccord Genuity Growth Conference on Tuesday, August 10th at ... at the InterContinental Hotel in Boston .  The Canaccord Genuity Growth ... and industry leaders.   , , ...
Cached Biology Technology:New Test Centre in India: TUV Rheinland Continues Worldwide Investment Programme for Solar Industry 2New Test Centre in India: TUV Rheinland Continues Worldwide Investment Programme for Solar Industry 3Pitt-led researchers to build foundation for quantum supercomputers with $7.5 million federal grant 2AVANIR to Present at the Canaccord Genuity Growth Conference 2
Sequencing and primer design rolled into one. Just give us your clone and a reference sequence, and we'll do the rest. Single-strand or double-strand coverage. Guaranteed results....
... polyclonal antibody to human XAB2 (amino terminus) ... identified through its interaction with XPA. Immunoprecipitation ... of XAB2 interacts with the transcription-coupled repair-specific ... with RNA polymerase II. Microinjection experiments with ...
... provide custom microplate coating using advanced automated high throughput microplate ... formats. We can also accommodate virtually any lot size of ... , 8 and 12 ... 384 well microplate, ...
...
Biology Products: