Navigation Links
Eisai announces Phase II data on E7389, a potential new therapy for the treatment of breast cancer

Researchers today presented preliminary safety and efficacy data for E7389 in the treatment of advanced, refractory breast cancer during the San Antonio Breast Cancer Symposium. E7389 is a synthetic analog of halichondrin B (HB), which is a natural product shown in preclinical studies to have highly potent anti-cancer activity in vitro and in vivo. Halichondrin B was originally isolated from a type of marine sponge.

This study was designed to evaluate E7389 as a monotherapy in patients with refractory breast cancer. The primary endpoint of this trial was response rate, measured using the RECIST (Response Evaluation Criteria In Solid Tumors) criteria ?a group of standards used to measure responses to treatment in solid tumors.

Of the 65 evaluable patients, 10 partial responses were confirmed at the 4th cycle assessment. Twenty-one patients had stable disease (SD). In treatment-refractory patients with advanced breast cancer this preliminary response rate (15%) appears promising.

Based on the preliminary results of this study, the predominant serious side effect related to E7389 was neutropenia (low white blood cell counts). Other side effects were considered mild to moderate and included nausea, fatigue, dehydration, arthralgias, dyspnea and neuropathy. None of the patients discontinued the study due to hematological toxicity.

"The results from this study with E7389 appear promising, and clinical research on E7389 as a treatment for breast cancer is continuing," said Sandra Silberman, MD, PhD, Associate Vice President and Global Therapeutic Area Head, Oncology at Eisai Medical Research Inc. "E7389 is an example of Eisai's human health care (hhc) commitment to satisfy unmet medical needs of patients and their families. Eisai has targeted oncology/critical care as one of three key therapeutic areas of focus," she added.

Seventy-one women were enrolled in the 28-day cycle patient group. Preliminary efficacy data for 65 patients
'"/>

Source:JFK Communcations


Page: 1 2

Related biology news :

1. Wiley announces publication of Databasing the Brain
2. Nonlinear Dynamics announces more details of its global partnership with PerkinElmer
3. Neurologix announces positive results of gene therapy clinical trial in Parkinsons disease
4. GlycoFi announces the first production of antibodies with human glycosylation in yeast
5. NHGRI announces new sequencing targets
6. CHAVI announces international search for genes affecting HIV response
7. NHGRI announces latest sequencing targets
8. MUHC announces a transplant first in Quebec
9. St. Jude announces breakthrough in eye cancer treatment
10. NIH announces phase III clinical trial of creatine for Parkinsons disease
11. FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
Post Your Comments:
(Date:4/18/2014)... survey of emergency contraceptive pills in Peru found ... either of substandard quality or falsified. Many pills ... the wrong active ingredient. One batch had no ... the fake drugs, researchers at the Georgia Institute ... spectrometry to quickly assess suspected counterfeit drugs and ...
(Date:4/18/2014)... to the story of how barnyard chickens came to be, ... journal Proceedings of the National Academy of Sciences . ... 200-2300 years ago in Europe, researchers report that just a ... different from the chickens we know today. , The results ... domestic chickens -- such as their yellowish skin -- only ...
(Date:4/17/2014)... In the most densely forested and most densely ... centuries of human needs, values and practices. Disturbances associated ... for agriculture and development, have set the stage for ... Service study reports. , The report Five anthropogenic ... needs in the Northern United States was ...
Breaking Biology News(10 mins):Counterfeit contraceptives found in South America 2Counterfeit contraceptives found in South America 3Ancient DNA offers clues to how barnyard chickens came to be 2Five anthropogenic factors that will radically alter northern forests in 50 years 2Five anthropogenic factors that will radically alter northern forests in 50 years 3
... found in the blood of marine mammals and fish-eating ... previously been thought. Research published in BioMed Central,s open ... harms T-lymphocytes, key cells in a seal,s immune system. ... Mercury exposure is known to occur as a result ...
... scientists were dubious in the early 1980s when they stumbled ... not only were they not supposed to be there, but ... detaching from proteins, effectively switching them on and off. ... on and off -- and thus determining their actions -- ...
... The American Institute of Aeronautics and Astronautics (AIAA) ... The New Horizons Forum, and Aerospace Exposition, January 5-8 ... This year,s Aerospace Sciences Meeting will combine three distinct ... the present and the future of the aerospace enterprise ...
Cached Biology News:Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk 2Aerospace sciences meeting to be held Jan. 5-8 in Orlando 2
(Date:1/15/2014)... ON (PRWEB) January 15, 2014 AudioNotch ... experimental new therapy for the treatment of tinnitus. Patients ... tinnitus frequency, and over a period of weeks to months, ... Sound Therapy in two forms: Notched Music and Notched White ...
(Date:1/14/2014)... DC (PRWEB) January 14, 2014 Carahsoft ... for Thursday, January 23, 2014 at 2pm EST (11am ... Knowledge.” The topic focuses on how technology can turn ... critical decisions for government agencies. The online webinar will ...
(Date:1/14/2014)... 14, 2014 As pet owners drew up their lists of ... wrote: "Take better care of my furry companion." Nowadays there are ... top-brand carrying cases to take the little canine or feline darlings ... compelled to buy some pricey toys at the pet store. But ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014 ... two institutes from the National Institutes of Health (NIH) ... safer, more effective treatments to patients on a faster ... Advancing Translational Sciences (NCATS) and the National Eye Institute ...
Breaking Biology Technology:Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3
... Inc. (Nasdaq: SNUS ) today announced that it ... on July 16,2008 indicating that the NASDAQ Panel has ... its securities on The NASDAQ Global,Market. The Company,s continued ... conditions by August 29, 2008, including the,implementation of a ...
... (NYSE:,LDR), will release financial results for the fiscal ... 2008., The company will host a conference ... 2:00 p.m. Eastern Time. Investors may access the ... and Canada), or 303-262-2137,(international callers), or by visiting ...
... July 17 Silence Therapeutics plc (London AIM:,SLN), ... that,for personal reasons, Jeffery Vick has resigned as ... of Directors has appointed Iain Ross, currently Non-Executive,Chairman, ... effect. Jeremy,Curnock Cook, a Non-Executive Director of the ...
Cached Biology Technology:Sonus Pharmaceuticals Receives Favorable NASDAQ Decision 2Sonus Pharmaceuticals Receives Favorable NASDAQ Decision 3Organizational Changes at Silence Therapeutics 2Organizational Changes at Silence Therapeutics 3
The novel and unique HCTplus delivers unmatched information-rich data-dependent LC/MSn data for todays challenge in proteomics and metabonomics work....
... Adding an exciting new chapter ... GC leadership, Agilents 7890A GC ... to take your lab to ... and GC/MS performance, including advanced ...
... In the six short years since ... Dr. John Walkers widely acclaimed Protein Protocols ... developments in protein biochemistry. In recognition of ... and the rapid evolution of new methodologies ...
... call for critical, but time-consuming optimization ... siRNA transfection protocols resulting in less ... be used to efficiently transfect adherent ... without increased cytotoxicity. From start to ...
Biology Products: