Navigation Links
Einstein scientists discover how protein crucial for motion is synthesised at the right place in the cell

Researchers at the Albert Einstein College of Medicine and the German Cancer Research Institute have shown how protein synthesis is targeted to certain regions of a cell--a process crucial for the cellular motility that governs nerve growth, wound healing and cancer metastasis. Their study appears in the November 24 issue of the journal Nature.

Led by Drs. Robert Singer and Dr Stefan Huettelmaier, the research team focused on migrating fibroblast cells important in wound healing. To move towards a wound, these cells manufacture the protein actin, which polymerizes into long filaments that push the cell's membrane outward to form protrusions.

The team's previous work showed how newly formed actin messenger RNA molecules find their way to the cell's periphery: A protein called ZBP1 binds to the messenger RNA and "escorts" it out of the fibroblast nucleus and into the cytoplasm. On reaching the cell's periphery, the messenger RNA is translated into actin protein responsible for cell motility.

This new study reveals another key role for ZBP1: Not only does ZBP1 bind to actin messenger RNA and guide it to the cell's periphery, but it also helps regulate where in the cell the messenger RNA is translated into actin.

"The ZBP1 bound to actin's messenger RNA acts like a lock to prevent it from being translated into protein before reaching its destination," explains Dr. Singer. "On arriving at the cell periphery, the messenger RNA/ZBP1 complex encounters an enzyme, the protein kinase Src, which is active only in that part of the cell. Src adds a phosphate group to ZBP1 close to where it binds to messenger RNA, and this phosphorylation reaction detaches ZBP1 from the actin messenger RNA--unlocking the messenger RNA so it can now be translated into the actin protein that makes cell movement possible."

Understanding how actin synthesis is spatially regulated in motile cells could lead to new cancer therapies. "In cancer," says Dr. Singer , "we know that expression of ZBP1 correlates with benign tumors, while suppression of ZBP1 is associated with metastasis--when motile cancer cells break off from the primary tumor and invade other areas of the body. So a drug that could force tumor cells to express ZBP1 might prevent cancers from spreading."

In addition to Dr. Singer, other Einstein researchers involved in the study are Dr. John Condeelis, professor and co-chair with Dr. Singer of Einstein's Department of Anatomy and Structural Biology, Daniel Zenklusen, Mike Lorenz, XiuHua Meng, and Jason Dictenberg of that department, Gary J. Bassell of the Department of Neuroscience at Einstein, and Dr. Marcell Lederer, now in Dr. Huettelmaier's laboratory of Martin-Luther-University of Halle, Germany.


'"/>

Source:Albert Einstein College of Medicine


Related biology news :

1. Einstein researchers identify new way that bacteria develop resistance to antibiotics
2. Study by Einstein researchers could lead to a novel strategy for treating obesity
3. Einstein researchers take the pulse of a gene in living cells
4. Einstein researchers demonstrate a novel approach to treating AIDS
5. Einsteins tea leaves inspire new blood separation technique
6. Wisconsin scientists grow critical nerve cells
7. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
8. UAB scientists discover the origin of a mysterious physical force
9. Fox Chase Cancer Center scientists identify immune-system mutation
10. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
11. U-M scientists find genes that control growth of common skin cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/4/2017)... VEGAS , Jan. 4, 2017  For the thousands of attendees ... a global leader in connected health and biometric measurement devices and services, ... monitors. On display in A&D Medical,s special CES Exhibit ... represent the ongoing expansion of the company,s WellnessConnected product platform.  ... ...
(Date:1/3/2017)... , Jan. 3, 2017 Onitor, provider of ... of Onitor Track, an innovative biometric data-driven program designed ... this month at the 2017 Consumer Electronics Show (CES) ... In the U.S., the World Health Organization (WHO), ... two-thirds of adults who are overweight or obese. WHO ...
(Date:12/22/2016)... 2016 SuperCom (NASDAQ:   ... the e-Government, Public Safety, HealthCare, and Finance sectors announced today that ... selected to implement and deploy a community-based supportive services program to ... , further expanding its presence in the state. ... This new program, which is ...
Breaking Biology News(10 mins):
(Date:1/23/2017)... , ... January 23, 2017 , ... CallTower ... an INTERNET TELEPHONY Product of the Year Award winner for 2017. , For ... in unified communications solutions. In 2016, CallTower was awarded with the hosted VoIP Excellence ...
(Date:1/21/2017)... Colo. , Jan. 20, 2017 ... or the "Company"), announced that on January 14, 2017 ... plan under which the Company will terminate certain employees ... Bioptix Diagnostics, Inc.  The Company commenced terminations on January ... within 30 days.  The Company may pay severance benefits ...
(Date:1/20/2017)... 2017 Ginkgo Bioworks, the organism company, ... in the synthesis and assembly of DNA. The ... pathway-length synthetic DNA into Ginkgo,s automated organism engineering ... construction of new organism designs for application across ... was founded to significantly increase the world,s capacity ...
(Date:1/19/2017)... and HOUSTON , Jan. ... Prenatal") today announced the formation of its Medical/Clinical ... clinicians and industry veterans who enhance the range ... it accelerates development of its novel prenatal diagnostic ... medical, clinical and strategic guidance for the company,s ...
Breaking Biology Technology: