Navigation Links
Einstein scientists discover how protein crucial for motion is synthesised at the right place in the cell

Researchers at the Albert Einstein College of Medicine and the German Cancer Research Institute have shown how protein synthesis is targeted to certain regions of a cell--a process crucial for the cellular motility that governs nerve growth, wound healing and cancer metastasis. Their study appears in the November 24 issue of the journal Nature.

Led by Drs. Robert Singer and Dr Stefan Huettelmaier, the research team focused on migrating fibroblast cells important in wound healing. To move towards a wound, these cells manufacture the protein actin, which polymerizes into long filaments that push the cell's membrane outward to form protrusions.

The team's previous work showed how newly formed actin messenger RNA molecules find their way to the cell's periphery: A protein called ZBP1 binds to the messenger RNA and "escorts" it out of the fibroblast nucleus and into the cytoplasm. On reaching the cell's periphery, the messenger RNA is translated into actin protein responsible for cell motility.

This new study reveals another key role for ZBP1: Not only does ZBP1 bind to actin messenger RNA and guide it to the cell's periphery, but it also helps regulate where in the cell the messenger RNA is translated into actin.

"The ZBP1 bound to actin's messenger RNA acts like a lock to prevent it from being translated into protein before reaching its destination," explains Dr. Singer. "On arriving at the cell periphery, the messenger RNA/ZBP1 complex encounters an enzyme, the protein kinase Src, which is active only in that part of the cell. Src adds a phosphate group to ZBP1 close to where it binds to messenger RNA, and this phosphorylation reaction detaches ZBP1 from the actin messenger RNA--unlocking the messenger RNA so it can now be translated into the actin protein that makes cell movement possible."

Understanding how actin synthesis is spatially regulated in motile cells could lead to new cancer therapies. "In cancer," says Dr. Singer
'"/>

Source:Albert Einstein College of Medicine


Page: 1 2

Related biology news :

1. Einstein researchers identify new way that bacteria develop resistance to antibiotics
2. Study by Einstein researchers could lead to a novel strategy for treating obesity
3. Einstein researchers take the pulse of a gene in living cells
4. Einstein researchers demonstrate a novel approach to treating AIDS
5. Einsteins tea leaves inspire new blood separation technique
6. Wisconsin scientists grow critical nerve cells
7. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
8. UAB scientists discover the origin of a mysterious physical force
9. Fox Chase Cancer Center scientists identify immune-system mutation
10. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
11. U-M scientists find genes that control growth of common skin cancer
Post Your Comments:
(Date:11/21/2014)... , Nov. 20, 2014 Strict laws against ... are piloting the North American and European automotive sector ... growing, gesture recognition systems that are intuitive and able ... in the industry. New analysis from ... Recognition Market in Europe and ...
(Date:11/18/2014)... , Nov. 17, 2014   ... EMC collaborate to develop The Partners Data Lake, ... The Partners Data Lake will allow researcher and ... diagnostics, treatment and the lives of patients ... and clinical activities across the Partners system, breaking ...
(Date:11/12/2014)... , Nov. 12, 2014 Crossmatch™, a leading ... its U.are.U ® fingerprint readers have been deployed ... Central Mexico . The bakery chain ... eliminate payroll issues caused by employees clocking in for ... U.are.U fingerprint readers, Montparnasse relied on paper timecards and ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2
... available in Spanish . , Feeding the amino ... regular diet makes them less aggressive and easier to manage, ... and cooperators. The tryptophan-enhanced diet reduced aggression and overall ... Tryptophan, which is only acquired through diet, is the precursor ...
... an ongoing effort to mirror the ability of biological ... scientists from the McGowan Institute for Regenerative Medicine have ... both biological and chemical toxins. They described the findings ... biological principles to create materials that can do many ...
... The Center for Wireless Information Network Studies (CWINS) ... $1.2 million award from the National Institute of Standards ... the propagation of radio waves around and through the ... and computer engineering and director of CWINS, the research ...
Cached Biology News:Tryptophan-enriched diet reduces pig aggression 2Multifunctional polymer neutralizes both biological and chemical weapons 2WPI receives $1.2 million NIST award for pioneering study of wireless body area networks 2WPI receives $1.2 million NIST award for pioneering study of wireless body area networks 3
(Date:11/26/2014)... -- Theravalues Corporation est fier d,annoncer le lancement ... salon Hi Europe 2014 (du 2 au 4 décembre ... Curcumine la plus biodisponible actuellement sur le marché, ... ingrédients approuvés par les règlements européens. ... la racine de curcuma ( Curcuma longa ) ...
(Date:11/24/2014)... Five American winners will receive ... Awards for Medical Sciences", in its 8 th ... , on 15 December 2014.      ... Carter Center which won the Hamdan Award for Volunteers ... programs that aim to improve health and promote peace ...
(Date:11/24/2014)... USA (PRWEB) November 23, 2014 One of ... field of optics and photonics is now available to high ... very low cost. SPIE, the international society for optics ... to the complete SPIE Digital Library available to ... price. , “Light-based technologies are integral to all areas of ...
(Date:11/24/2014)... Senior Vice President, General Manager for Clinical ... acumen Elsevier , a world-leading provider ... congratulates Diane Bartoli , Senior Vice President and ... Solutions, for being recognized in the 13 th ... Profiles in Diversity Journal ® . ...
Breaking Biology Technology:La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 3Five US Winners Among Recipients of Hamdan Medical Awards 2SPIE Digital Library Now Available to High Schools, Two-Year Colleges at No or Low Cost 2Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 2Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 3
... April 27 Cellectricon, a leading,provider of ... announced,its collaboration with BioFocus DPI, a contract ... screening. BioFocus DPI will utilize,Cellectricon,s Dynaflow(R)HT, a ... increase its electrophysiology-based screening capacity, particularly,for fast ...
... SALEM, Mass., April 27 LaVoie Group, a life ... been selected as investor relations agency of record for ... of LaVoie Group, commented, "Pegasus has the opportunity to ... The Company is changing the standard of care ...
... MISSISSAUGA, ON, April 24 /PRNewswire-FirstCall/ - Vasogen Inc. (NASDAQ: ... will succeed Terrance H. Gregg as Chairman of its Board ... Gregg,s resignation from Vasogen,s Board is due to the requirements ... , Dr. Smith, a Vasogen Board member since 1998, is ...
Cached Biology Technology:Cellectricon and BioFocus DPI Advance High Throughput ion Channel Drug Discovery 2LaVoie Group Adds Bio-Surgery Company, Pegasus Biologics, to Its Life Sciences Agency Roster 2Vasogen Appoints Dr. Eldon Smith Chairman 2Vasogen Appoints Dr. Eldon Smith Chairman 3
... Purification Kit, 100. For the purification, isolation and ... kb) from solution and from TAE or TBE ... in as little as 5 min or from ... fiber matrix columns provide consistent results and reduce ...
BD BaculoGold Max-XP Insect Cell Medium 1 Liter...
Performance, mycoplasma, virus, and endotoxin tested...
... 10X BlueJuice Gel ... for easy loading and ... in agarose or native ... buffer features higher density ...
Biology Products: