Navigation Links
Einstein researchers identify new way that bacteria develop resistance to antibiotics

Scientists at the Albert Einstein College of Medicine have discovered a novel strategy by which the bacterium that causes tuberculosis may soon be able to resist the effects of antibiotics known as fluoroquinolones. The finding explains why several disease-causing microbes, including Shigella and E. coli, are rapidly becoming resistant to fluoroquinolones.

The international research effort was led by Dr. John S. Blanchard, the Dan Danciger Professor of Biochemistry at the Albert Einstein College of Medicine. The findings are published in the June 3 issue of Science.

Fluoroquinolones, an important class of antibiotics that includes ciprofloxacin (Cipro), work against TB by interfering with the microbe's ability to reproduce itself. Specifically, the drugs target an enzyme called DNA gyrase, which helps untwist bacterial DNA during replication. However, TB has been developing resistance to fluoroquinolones due to their increasing use in treating multi-drug-resistant TB infections.

Until recently, this resistance was due entirely to mutations in DNA gyrase that prevent fluoroquinolones from binding to the complex formed by the enzyme and DNA. Now, the Science article has identified a new strategy by which TB bacteria may be able to resist fluoroquinolones--and that other microbes are already using.

After studying the three-dimensional structure of a TB protein called MfpA, the researchers found that the protein contains a fold that mimics DNA. So rather than binding with DNA--and becoming a target for the fluoroquinolones--DNA gyrase instead binds with the DNA "mimic" MfpA, rendering the fluoroquinolones ineffective. Proteins similar to MfpA are also present in Shigella, E. coli and other disease-causing bacteria that have developed fluoroquinolone resistance.

"Our study shows that this novel bacterial mechanism is responsible for the rapid spread of fluoroquinolone resistance that is making hospital-acquired infections so difficu lt to treat," says Dr. Blanchard.

Additional members of the research team were postdoctoral fellows Subray S. Hegde and Matthew W. Vetting, and Dr. Steven L. Roderick (Albert Einstein College of Medicine in Bronx, NY); Dr. Anthony Maxwell (The John Innes Centre in Norwich, England); and Dr. Howard E. Takiff (Instituto Venezolano de Investigaciones Cientificas in Caracas, Venezuela).


'"/>

Source:Albert Einstein College of Medicine


Related biology news :

1. Einstein scientists discover how protein crucial for motion is synthesised at the right place in the cell
2. Study by Einstein researchers could lead to a novel strategy for treating obesity
3. Einstein researchers take the pulse of a gene in living cells
4. Einstein researchers demonstrate a novel approach to treating AIDS
5. Einsteins tea leaves inspire new blood separation technique
6. NYU researchers simulate molecular biological clock
7. Vital step in cellular migration described by UCSD medical researchers
8. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
9. UCSD researchers maintain stem cells without contaminated animal feeder layers
10. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
11. New protein discovered by Hebrew University researchers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ... of online age and identity verification solutions, announced today ... Identity Conference 2017, May 15 thru May 17, 2017, ... Building and International Trade Center. Identity ... globe and in today,s quickly evolving digital world, defining ...
(Date:4/19/2017)... 19, 2017 The global military ... is marked by the presence of several large global ... by five major players - 3M Cogent, NEC Corporation, ... for nearly 61% of the global military biometric market ... the global military biometrics market boast global presence, which ...
(Date:4/13/2017)... According to a new market research report "Consumer ... Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - ... to grow from USD 14.30 Billion in 2017 to USD 31.75 Billion ... ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... ... August 16, 2017 , ... Today, ... announced it has secured $2M in funding from an impressive group of investors, ... and SVG Thrive Fund. With this investment, 3Bar is broadening availability of its ...
(Date:8/15/2017)... After spending the past two years building a state-of-the-art ... GeneFo now offers this platform to healthcare stakeholders (hospitals, foundations, biopharma ... and data collection vis a vis their members, under their own ... of this offer. ... ...
(Date:8/15/2017)... ... 2017 , ... Any expert in stem cell research or stem cell medicine ... half a century. Despite their essential roles in human health and regenerative medicine, ... tags developed for this purpose also tag other, more abundant, non-stem tissue cells ( ...
(Date:8/15/2017)... PA (PRWEB) , ... August 15, 2017 , ... ... and encrypted shopping cart. Now mobile responsive, the new website makes it easy ... or anywhere in between. Users can now find detailed product information, educational industry ...
Breaking Biology Technology: