Navigation Links
Einstein researchers identify new way that bacteria develop resistance to antibiotics

Scientists at the Albert Einstein College of Medicine have discovered a novel strategy by which the bacterium that causes tuberculosis may soon be able to resist the effects of antibiotics known as fluoroquinolones. The finding explains why several disease-causing microbes, including Shigella and E. coli, are rapidly becoming resistant to fluoroquinolones.

The international research effort was led by Dr. John S. Blanchard, the Dan Danciger Professor of Biochemistry at the Albert Einstein College of Medicine. The findings are published in the June 3 issue of Science.

Fluoroquinolones, an important class of antibiotics that includes ciprofloxacin (Cipro), work against TB by interfering with the microbe's ability to reproduce itself. Specifically, the drugs target an enzyme called DNA gyrase, which helps untwist bacterial DNA during replication. However, TB has been developing resistance to fluoroquinolones due to their increasing use in treating multi-drug-resistant TB infections.

Until recently, this resistance was due entirely to mutations in DNA gyrase that prevent fluoroquinolones from binding to the complex formed by the enzyme and DNA. Now, the Science article has identified a new strategy by which TB bacteria may be able to resist fluoroquinolones--and that other microbes are already using.

After studying the three-dimensional structure of a TB protein called MfpA, the researchers found that the protein contains a fold that mimics DNA. So rather than binding with DNA--and becoming a target for the fluoroquinolones--DNA gyrase instead binds with the DNA "mimic" MfpA, rendering the fluoroquinolones ineffective. Proteins similar to MfpA are also present in Shigella, E. coli and other disease-causing bacteria that have developed fluoroquinolone resistance.

"Our study shows that this novel bacterial mechanism is responsible for the rapid spread of fluoroquinolone resistance that is making hospital-acquired infections so difficu lt to treat," says Dr. Blanchard.

Additional members of the research team were postdoctoral fellows Subray S. Hegde and Matthew W. Vetting, and Dr. Steven L. Roderick (Albert Einstein College of Medicine in Bronx, NY); Dr. Anthony Maxwell (The John Innes Centre in Norwich, England); and Dr. Howard E. Takiff (Instituto Venezolano de Investigaciones Cientificas in Caracas, Venezuela).


'"/>

Source:Albert Einstein College of Medicine


Related biology news :

1. Einstein scientists discover how protein crucial for motion is synthesised at the right place in the cell
2. Study by Einstein researchers could lead to a novel strategy for treating obesity
3. Einstein researchers take the pulse of a gene in living cells
4. Einstein researchers demonstrate a novel approach to treating AIDS
5. Einsteins tea leaves inspire new blood separation technique
6. NYU researchers simulate molecular biological clock
7. Vital step in cellular migration described by UCSD medical researchers
8. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
9. UCSD researchers maintain stem cells without contaminated animal feeder layers
10. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
11. New protein discovered by Hebrew University researchers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/21/2016)... , March 22, 2016 ... recognition with passcodes for superior security   ... a leading provider of secure digital communications services, today ... biometric technology and offer enterprise customers, particularly those in ... facial recognition and voice authentication within a mobile app, ...
(Date:3/15/2016)... 2016 --> --> ... Market Research "Digital Door Lock Systems Market - Global Industry ... the global digital door lock systems market in terms of ... is forecast to grow at a CAGR of 31.8% during ... medium enterprises (MSMEs) across the world and high industrial activity ...
(Date:3/14/2016)... 2016 http://www.apimages.com ) - ... - Renvoi : image disponible via AP Images ... --> DERMALOG, le leader de ... lecteurs d,empreintes digitales pour l,enregistrement des réfugiés en ... pour produire des cartes d,identité aux réfugiés. DERMALOG ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... WARSAW, Ind. , May 23, 2016 Zimmer ... in musculoskeletal healthcare, today announced that its Board of Directors ... stockholders for the second quarter of 2016. ... on or about July 29, 2016 to stockholders of record ... Future declarations of dividends are subject to approval of the ...
(Date:5/23/2016)... (PRWEB) , ... May 23, 2016 , ... ... building management solutions and services based in Aurora, Ohio, has broken ground on ... business in the Research Triangle Park area, this new location solidifies a commitment ...
(Date:5/20/2016)... ... May 20, 2016 , ... The leading Regenerative Veterinary Medicine Company, ... clients have treated over 100 of their own patients with the VetStem Cell Therapy. ... level of care for their patients. , The veterinarians are Dr Ross Rich ...
(Date:5/20/2016)... ... May 20, 2016 , ... The recent recall by Costco and ... Food Safety News on May 12, 2016(1), demonstrates the need for faster and more ... Baltimore-based biotech firm, PathSensors, Inc. , PathSensor’s latest solution uses a ...
Breaking Biology Technology: