Navigation Links
Effective HIV control may depend on viral protein targeted by immune cells

d be destroyed. Earlier studies, including a 2004 Nature report from the same group, showed that the genetically determined version of an individual’s HLA Class I molecules could strongly influence immune control of HIV.

The current study found that only CD8 responses against the Gag protein were associated with significantly reduced viral levels and that individuals with responses against several different Gag fragments had even lower viral loads. In contrast, those with stronger responses against other HIV proteins ?including Env, a protein that is the focus of several vaccine studies ?had higher viral levels indicating poorer control of HIV.

In people receiving no antiretroviral treatment, the improved HIV control associated with Gag-specific CD8 response would probably translate into asymptomatic infection for more than a decade, compared with progression to AIDS within two to three years of infection in those with no Gag responses. The reason why patients?particular HLA Class I molecules are linked to different HIV disease outcomes now appears to be related to the number of Gag fragments displayed by different versions of the Class I molecule.

Mechanisms underlying the different effects of the protein-specific immune responses are unknown and require further investigation. The researchers suggest that responses against proteins like Env might be inherently less effective or might only be generated in response to elevated viral loads. Therefore, the findings of this study, which reflect chronic HIV infection, might not apply in situations in which vaccination generates an immune response before infection occurs.

"The possibility that there may be fundamental differences between the impact of Gag and non-Gag CD8 responses on the ability to control HIV has clear relevance to vaccine development," says Goulder, who is an associate professor of Medicine at Harvard Medical School.
'"/>

Source:Massachusetts General Hospital


Page: 1 2

Related biology news :

1. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
2. Effective Cancer Treatments Follow The Clock
3. FDA Works To Speed The Advent Of New, More Effective Personalized Medicines
4. Fungus Effective Against Winged Termites
5. NCI Researchers Confirm the Effectiveness of Immunotherapy Approach to Treating Melanoma
6. Effective, safe anthrax vaccine can be grown in tobacco plants
7. Ancient olfaction protein is shared by many bugs, offering new pest control target
8. Gene variations explain drug dose required to control seizures
9. U-M scientists find genes that control growth of common skin cancer
10. Scientists discuss improved biopesticides for locust control in West Africa
11. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
Post Your Comments:
(Date:3/20/2015)... 2015 Research and Markets ( ... "India Sensors Market Forecast and Opportunities 2020" ... sensor market is projected to grow at a ... electronics, automotive, industrial and healthcare sectors are the ... In addition, adoption of MEMS technology in sensors ...
(Date:3/20/2015)... March 20, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces ... one of the products featured in 2015 "I Want ... 11:00 PM EST on the DIY Network.   ... Las Vegas , site of the 2015 International ...
(Date:3/19/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... mobile commerce market, announces its biometric payment technology, the Wocket® ... this week on Washington DC,s Fox ... segment "The Next Great Thing", host Laura Evans ... and ,a really big breakthrough in mobile payment.,  ...
Breaking Biology News(10 mins):India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3
... episodes of reduced precipitation in the Southern Rocky Mountains, especially ... of mountain pine beetles. The overabundance is a threat to ... the evolution of the current pine beetle epidemic in the ... in the two primary host species, the ponderosa pine and ...
... been great advancements in the development of the high-strength ... grow. Various industries have a need for structural components ... emissions and pollution increase safety and cost less to ... of researchers in Wayne State University,s College of Engineering ...
... herpes virus particles attack a skin cell in the first stage ... may be vulnerable to medical treatment. Unlike most viruses ... particles, herpes simplex virus type 1 (HSV-1) a virus that ... two viral particles to infect a skin cell in the first ...
Cached Biology News:Drought in 2001-2002 fueled Rocky Mountain pine beetle outbreak 2Drought in 2001-2002 fueled Rocky Mountain pine beetle outbreak 3Drought in 2001-2002 fueled Rocky Mountain pine beetle outbreak 4High-strength material advancements at Wayne State University may lead to new, life-saving steel 2Princeton researchers identify unexpected bottleneck in the spread of herpes simplex virus 2Princeton researchers identify unexpected bottleneck in the spread of herpes simplex virus 3
(Date:4/16/2015)... IL (PRWEB) April 16, 2015 Regis ... the American Association for Cancer Research (AACR) annual meeting. ... Pennsylvania Convention Center, starting Saturday, April 18, in Philadelphia ... holds claim to title of the oldest and largest ... provides fellowships and grants, and partners with survivors to ...
(Date:4/16/2015)... April 16, 2015 The Council ... the prestigious 2015 Borlaug CAST Communication Award goes ... at Tuskegee University in Alabama. Award nominees must ... public presentations; and/or the use of television, radio, ... three areas. As a specialist in the field ...
(Date:4/16/2015)... 16, 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ... joint venture with G-treeBNT (ReGenTree LLC) has retained ... trial for the orphan disorder, neurotrophic keratopathy (NK), ... eye syndrome (DES) in the U.S.  Both trials ... this year.  Each of these eye disorders was ...
(Date:4/16/2015)... PHOENIX, AZ (PRWEB) April 16, 2015 ... and makes it easier for research institutions to learn ... collect clinical data. , The timing is ideal since ... on Tuesday. Research Kit is an open-source framework for ... 9. It provides a way for researchers to collect ...
Breaking Biology Technology:Regis Technologies Joins American Association for Cancer Research Annual Meeting 2The 2015 Borlaug CAST Communication Award Goes to Channapatna Prakash 2RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 2RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 3RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 4RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 5Infographic Illustrates Potential for Research Kit to Impact Clinical Research 2Infographic Illustrates Potential for Research Kit to Impact Clinical Research 3
... Acquisition of Remainder of NexGen Diagnostics Captures Promising ... Intellectual ... BEC ), a leading developer of products that simplify and,automate complex ... acquire the remaining 80.1 percent of NexGen,Diagnostics LLC, a spin out ...
... Marks & Co. LP has partnered,with BlueStar Capital Management ... LP. The partnership also gives Carl Marks a stake ... and an,increased presence in the healthcare investment sector., ... which are,long and short public healthcare equities, in both ...
... announced today,the presentation of the results obtained so far ... and Dr. John Barrett* of the National,Heart, Lung, and ... Health (NIH) on Kiadis, lead product ATIR at the ... According to the NHLBI investigators the challenge in the ...
Cached Biology Technology:Beckman Coulter to Acquire Exclusive Rights to Break-Through Technologies 2Carl Marks Seeds New Healthcare Fund Through Strategic Partnership With BlueStar Capital Management 2Promising Data ATIR Studies Presented by NIH Investigators 2
BD BioCoat Poly-D-Lysine/Laminin 100 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of poly-D-lysine and laminin....
...
...
BD BioCoat Osteologic Coverslips that have been sterilized by ETO gas. Coating : Osteologic&trade ,Thickness : 0.16 mm ,Diameter : 12.7 mm ,Gridded : No ...
Biology Products: