Navigation Links
Effective Cancer Treatments Follow The Clock

Interesting application of chronopharmacology :

Oncologists have long thought that cancer treatments tend to be more effective at certain times of day. But they have been unable to turn this knowledge into practice, because they did not understand the phenomenon well enough. Now, researchers have discovered a molecular mechanism that explains why sensitivity to anti-cancer drugs changes with the clock. They said their findings could lead to new drug treatments that may be more effective because they harness the power and precision of the body's internal clock.

The research team, which included senior author Joseph S. Takahashi, a Howard Hughes Medical Institute investigator at Northwestern University, and senior author Marina P. Antoch at the Cleveland Clinic Lerner Research Institute in Cleveland, Ohio, published its findings February 1, 2005, in the early online edition of the Proceedings of the National Academy of Sciences.

In experiments, which were conducted in mice, the scientists found that the body's internal biological clock affects the survival of immune cells that are targets of the anti-cancer drug cyclophosphamide (CY).

“We became interested in examining this issue because there is a long history of knowledge that chemotherapeutic agents produce different mortality and morbidity at different times of the day,?said Takahashi. The initial experiments with normal mice, performed by Antoch during her tenure in Takahashi's lab, confirmed that animals treated with CY survived better when they received treatment in late afternoon than those whose treatments were initiated early in the morning. Antoch further extended these original findings after she moved to Cleveland and established her research program in the Department of Cancer Biology at the Cleveland Clinic Foundation.

To examine the mechanism for this difference, Antoch and her
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3

Related biology news :

1. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
2. FDA Works To Speed The Advent Of New, More Effective Personalized Medicines
3. Fungus Effective Against Winged Termites
4. NCI Researchers Confirm the Effectiveness of Immunotherapy Approach to Treating Melanoma
5. Effective, safe anthrax vaccine can be grown in tobacco plants
6. Effective HIV control may depend on viral protein targeted by immune cells
7. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
8. Jump-starting T Cells In Skin Cancer
9. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
10. Fox Chase Cancer Center scientists identify immune-system mutation
11. Breakthrough Microarray-based Technology for the Study of Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Effective Cancer Treatments Follow The Clock

(Date:6/19/2013)... 2013  New York College of Health Professions announces ... and Trademark Office for detecting biometric changes through smart ... have been injured, attacked or killed. This ... Intellectual Properties Agreements of New York College of Health ... New York College says, "Our ...
(Date:6/19/2013)... expected to contribute to a very large and potentially ... a University of Michigan ecologist and colleagues who released ... Chesapeake Bay. , The Gulf forecast, one of two ... for an oxygen-depleted, or hypoxic, region of between 7,286 ... the 10 largest on record. , The low end ...
(Date:6/19/2013)... June 19, 2013 Elsevier, a world-leading provider of ... pleased to announce the launch of a new open ... launch of GeoResJ , Elsevier,s earth and planetary ... journal. The journal aims to provide a forum for ... science field. The journal will be co-edited by six ...
Breaking Biology News(10 mins):New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed 2New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed 3New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed 4U-M researcher and colleagues predict possible record-setting Gulf of Mexico 'dead zone' 2U-M researcher and colleagues predict possible record-setting Gulf of Mexico 'dead zone' 3U-M researcher and colleagues predict possible record-setting Gulf of Mexico 'dead zone' 4
... supported by the National Institute on Drug Abuse (NIDA), ... the first time identified genes that might increase a ... was conducted by Dr. George Uhl at NIDA’s Intramural ... Rose at the Center for Nicotine and Smoking Cessation ...
... Diseases (NIAID), part of the National Institutes of Health ... year for seven years to establish six Centers of ... will expand NIAID’s influenza surveillance program internationally and in ... key areas, including understanding how the virus causes disease ...
... reduced calorie intake can increase health and longevity. Professor ... discovered that reducing calorie intake later in life can ... of life-long calorie reduction. Importantly, this also includes anti-cancer ... establish a novel screening technique to find drugs which ...
Cached Biology News:NIDA study identifies genes that might help some people abstain from smoking 2NIAID expands capability for influenza research and surveillance 2NIAID expands capability for influenza research and surveillance 3NIAID expands capability for influenza research and surveillance 4It's never too late to get it back! Aging interrupted 2
(Date:6/18/2013)... Philadelphia, PA (PRWEB) June 18, 2013 ... fiber-optic Ball Lenses engineered of synthetic Sapphire and Glass ... stock sizes from Swiss Jewel Company , of ... performance by expanding and collimating the light beams without ... extreme optical clarity and natural durability (9 mohs) make ...
(Date:6/18/2013)... June 18, 2013 DuPont welcomes 48 ... 11th annual DuPont National AgriScience Teachers Ambassador Academy this ... in Chestertown, Md. , The NATAA “Ag ... and is a special project of the National ... Agricultural Educators (NAAE) . The highly recommended agriscience ...
(Date:6/18/2013)... -- RegeneCure announced today the start ... Bone Regeneration (GBR) Dental Membrane as a bone stimulating aid ... encountered when patients have a tooth replaced with a dental ... the implant. Consequently there is often a need to support ... regenerates. The bone substitute material, in turn, needs to be ...
(Date:6/18/2013)... June 18, 2013  regulated information — Global biopharmaceutical ... today announced the launch of a new Pledge ... The Pledge empowers the millions ... and make a personal commitment to demand more: greater ... care team and additional partial-onset seizure control.  More information ...
Breaking Biology Technology:Swiss Jewel Introduces the Crown Jewels of Fiber-Optic Connectors 2DuPont Sponsors National AgriScience Ambassador Academy 2DuPont Sponsors National AgriScience Ambassador Academy 3RegeneCure Starts Clinical Study Using Polymeric Bone Stimulating Membrane for Dental Implants 2RegeneCure Starts Clinical Study Using Polymeric Bone Stimulating Membrane for Dental Implants 3Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 2Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 3Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 4Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 5Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 6
... Funding Milestone Continues Progress at Seneca, Illinois ... ... NBF ) announced today that it has satisfied the conditions ... million,senior secured credit facility with WestLB AG, one of the world,s ...
... Phase 2b Trial Expected to Begin in the ... 4 Mpex Pharmaceuticals, Inc. today,announced that the ... Products Development has granted Mpex orphan drug designation ... pulmonary,infections due to Pseudomonas aeruginosa and other bacteria ...
... the Chinese Pharmaceutical ... CHENGDU, China, March 4 /Xinhua-PRNewswire-FirstCall/ -- Tianyin,Pharmaceutical, ... and,supplier of modernized traditional Chinese medicine ("TCM") based ... members:,Professor Zunjian Zhang, Ph.D., Professor Jianping Hou, Ph.D. ...
Cached Biology Technology:Nova Biosource Fuels Announces First Funding Under $41 Million Senior Secured Credit Facility 2Mpex Candidate, MP-376, Granted U.S. Orphan Drug Status for the Treatment of Cystic Fibrosis 2Mpex Candidate, MP-376, Granted U.S. Orphan Drug Status for the Treatment of Cystic Fibrosis 3Tianyin Pharmaceutical Appoints Three New Independent Board Members 2Tianyin Pharmaceutical Appoints Three New Independent Board Members 3Tianyin Pharmaceutical Appoints Three New Independent Board Members 4
in vitro Translation, Accessory Products...
Request Info...
... are K-12 derivatives that have mutations in ... reductase (gor) genes, which greatly enhances disulfide ... shown that expression in Origami(DE3) yielded 10-fold ... even though overall expression levels were similar ...
Request Info...
Biology Products: