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Ebola DNA vaccine produces immune responses in all fully vaccinated volunteers in Phase 1 trial

orts tested progressively higher doses of the vaccine at 2 mg (5 subjects), 4 mg (8 subjects), or 8 mg (8 subjects ?with 6 receiving the full three doses). Each cohort included two additional subjects who received placebo instead of active vaccine.

The vaccine was well tolerated, with no severe adverse reactions to the vaccine reported at any of the doses tested. Ebola-specific antibody responses against at least one of the encoded antigens were detected in all vaccine recipients. GP-specific antibody and T-cell responses were detected in all recipients who received the full three doses at all dose levels.


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Source:Porter Novelli, Life Sciences


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