Navigation Links
Early-stage sperm cells created from human bone marrow

Human bone marrow has been used to create early-stage sperm cells for the first time, a scientific step forward that will help researchers understand more about how sperm cells are created.

The research published today (Friday, April 13 2007), in the academic journal Reproduction: Gamete Biology, was carried out in Germany* by a team of scientists led by Professor Karim Nayernia, formerly of the University of Göttingen but now of the North-east England Stem Cell Institute (NESCI), based at the Centre for Life in Newcastle upon Tyne.

For the experiment, Prof Nayernia and his team took bone marrow from male volunteers and isolated the mesenchymal stem cells. These cells have previously been found to grow into other body tissues such as muscle.

They cultured these cells in the laboratory and coaxed them into becoming male reproductive cells, which are scientifically known as ‘germ cells? Genetic markers showed the presence of partly-developed sperm cells called spermatagonial stem cells, which are an early phase of the male germ cell development. In most men, spermatagonial cells eventually develop into mature, functional sperm but this progression was not achieved in this experiment.

Earlier research led by Prof Nayernia using mice, published in Laboratory Investigations, also created spermatagonial cells from mouse bone marrow. The cells were transplanted into mouse testes and were observed to undergo early meiosis - cell division - the next stage to them becoming mature sperm cells, although they did not develop further.

Talking about his newly published research paper, Prof Nayernia, of Newcastle University, said : "We’re very excited about this discovery, particularly as our earlier work in mice suggests that we could develop this work even further.

"Our next goal is to see if we can get the spermatagonial stem cells to progress to mature sperm in the laboratory and this should take aroun
'"/>

Source:University of Newcastle upon Tyne


Page: 1 2

Related biology news :

1. Early-stage immune system control of HIV may depend on inherited factors
2. Environmental chemical cocktail may sabotage sperm
3. Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory
4. UK sperm donor crisis
5. Protein translation in sperm
6. How sperm crack the whip
7. Chromosomal abnormalities in sperm higher after vasectomy reversal
8. Ecologists home in on how sperm whales find their prey
9. Study links high levels of nitric oxide to infertility and sperm DNA damage
10. Even when faint, ovary scent draws sperm cells
11. Single molecular mark seen as pivotal for genome compaction in spores and sperm
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Early stage sperm cells created from human bone marrow

(Date:6/17/2013)... 2013How kids eat their food may turn out to be ... new study out of St. Michael,s Hospital. , The ... a significant association between poor eating habits in kids ... or "bad" cholesterol, putting them at risk for cardiovascular ... the Canadian Medical Association Journal today. , ...
(Date:6/17/2013)... ST. LOUIS -- In research published in Biochemical ... describe a technology that can detect new, previously unknown ... for viruses even when doctors have not identified a ... , In the new approach, scientists use ... discover viruses. , Taking advantage of the complete deciphering ...
(Date:6/17/2013)... As mobile devices, smartphones and tablets ... grows exponentially, and biometric authentication offers that security, ... Reading Insider ( www.heavyreading.com/mobile-networks ), a subscription ... www.heavyreading.com ). Biometrics Offer Promise for ... authentication on smartphones, analyzing the most lucrative verticals ...
Breaking Biology News(10 mins):Poor eating behaviors may put preschoolers at risk for later health problems 2Saint Louis University researchers discover a way to detect new viruses 2Saint Louis University researchers discover a way to detect new viruses 3Biometric Authentication Provides Better Mobile Device Security, Heavy Reading Finds 2Biometric Authentication Provides Better Mobile Device Security, Heavy Reading Finds 3
... Autism Speaks, the worlds largest autism advocacy organization announces ... South and Central America. This multinational initiative will help ... public health and screening for early diagnosis and enhanced ... is important to form partnerships with countries that have ...
... the May 2008 Pediatric Academic Societies and Asian Society ... adolescent obesity negatively impacts vascular endothelial function, which relates ... in the U.S. during the past 20 years and ... The incidence of obesity in children is also increasing ...
... of Leicester engineer has won a share of grants ... In an unusual move, Dr. Declan Bates, a ... University of Leicester, is co-recipient of 1,068,000 in the ... Engineering and Physical Sciences Research Council (EPSRC) and the ...
Cached Biology News:Autism Speaks announces multinational initiative 2Study supports reason for concern in childhood and adolescent obesity 2Engineer to spearhead research into cell metabolism and medical injuries 2
(Date:6/19/2013)... Canada (PRWEB) June 19, 2013 ... trial business can potentially be worth up to ... this opportunity, the Indian government is taking serious ... trials the process. , This presentation will examine:, ... trial regulations ,     Immediate and long term ...
(Date:6/19/2013)... A new look at “big glass” and visionary ... highlight technical sessions at SPIE Photomask Technology 2013 ... year, the three-day event is the industry’s largest mask ... 100 technical presentations and numerous networking lunches and receptions. ... and photonics , the meeting will be held at ...
(Date:6/19/2013)... (PRWEB) June 19, 2013 Adding to ... is now stocked with Simport’s Dropette® and Heathrow ... at the customer doing basic biology, chemistry and any ... serology). , For over 35 years, Simport has been ... labware - products like the Simport Dropette®. Simport’s Dropette® ...
(Date:6/18/2013)... 17, 2013) A million electric cars could be on ... with the help of research by the United States Department ... Waterloo. , Professor Zhongwei Chen is part of a team ... non-precious materials to replace the expensive platinum catalysts in fuel ... of fuel cells in vehicles is the cost of the ...
Breaking Biology Technology:‘Big Glass’ and Visions for the Future are on the Program for SPIE Photomask Technology 2‘Big Glass’ and Visions for the Future are on the Program for SPIE Photomask Technology 3Leading Pipette Distributor Pipette.com Now Stocks Transfer Pipettes: Simport’s Dropette and Heathrow Scientific Disposable Plastic Transfer Pipettes 2US and Canadian researchers drive towards cheaper fuel cells for electric cars 2
... key engineering challenges to building a clean, efficient, hydrogen-powered ... enough raw hydrogen for a reasonable driving range would ... extremely low temperatures for liquid hydrogen. In a new ... Technologys Center for Neutron Research (NCNR) have demonstrated that ...
... 2008 With their ability to extend,product life, excipients ... strategy during lean times, and this portends a robust ... major life sciences market research,publisher. There are about 1200 ... This $4.6 billion market has witnessed healthy growth,in the ...
... April 2, 2008 PAREXEL International,Corporation (Nasdaq: ... services,organization, today announced that Larry Ereshefsky, Pharm.D., ... appointed as Vice Presidents,of Clinical Pharmacology Consulting ... These leading experts advise clients on,early phase ...
Cached Biology Technology:More solid than solid: A potential hydrogen-storage compound 2Excipients Help Pharma Extend Product Life, Profits 2PAREXEL Appoints Leading Central Nervous System Experts to Its Global Clinical Pharmacology Business 2PAREXEL Appoints Leading Central Nervous System Experts to Its Global Clinical Pharmacology Business 3PAREXEL Appoints Leading Central Nervous System Experts to Its Global Clinical Pharmacology Business 4PAREXEL Appoints Leading Central Nervous System Experts to Its Global Clinical Pharmacology Business 5
Plasmid expressing Zeocin resistance gene....
...
Hygromycin resistance gene (hph), provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
... template is designed to allow neomycin/kanamycin ... The FRT-PGK-gb2-neo-FRT template encodes the neomycin/kanamycin resistance ... for expression of kanamycin resistance in ... for expression of neomycin resistance in mammalian ...
Biology Products: