Navigation Links
Early-stage sperm cells created from human bone marrow

Human bone marrow has been used to create early-stage sperm cells for the first time, a scientific step forward that will help researchers understand more about how sperm cells are created.

The research published today (Friday, April 13 2007), in the academic journal Reproduction: Gamete Biology, was carried out in Germany* by a team of scientists led by Professor Karim Nayernia, formerly of the University of Göttingen but now of the North-east England Stem Cell Institute (NESCI), based at the Centre for Life in Newcastle upon Tyne.

For the experiment, Prof Nayernia and his team took bone marrow from male volunteers and isolated the mesenchymal stem cells. These cells have previously been found to grow into other body tissues such as muscle.

They cultured these cells in the laboratory and coaxed them into becoming male reproductive cells, which are scientifically known as ‘germ cells? Genetic markers showed the presence of partly-developed sperm cells called spermatagonial stem cells, which are an early phase of the male germ cell development. In most men, spermatagonial cells eventually develop into mature, functional sperm but this progression was not achieved in this experiment.

Earlier research led by Prof Nayernia using mice, published in Laboratory Investigations, also created spermatagonial cells from mouse bone marrow. The cells were transplanted into mouse testes and were observed to undergo early meiosis - cell division - the next stage to them becoming mature sperm cells, although they did not develop further.

Talking about his newly published research paper, Prof Nayernia, of Newcastle University, said : "We’re very excited about this discovery, particularly as our earlier work in mice suggests that we could develop this work even further.

"Our next goal is to see if we can get the spermatagonial stem cells to progress to mature sperm in the laboratory and this should take aroun d three to five years of experiments. I’ll be collaborating with other NESCI scientists to take this work forward.

Prof Nayernia says a lengthy process of scientific investigation is required within a reasonable ethical and social framework to be able to take this work to its next stage or to say if it has potential applications in terms of fertility treatments in humans.

Prof Nayernia gained worldwide acclaim in July 2006 when he announced in the journal Developmental Cell that he and colleagues had created sperm cells from mouse embryonic stem cells and used these to fertilise mice eggs, resulting in seven live births.
'"/>

Source:University of Newcastle upon Tyne


Related biology news :

1. Early-stage immune system control of HIV may depend on inherited factors
2. Environmental chemical cocktail may sabotage sperm
3. Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory
4. UK sperm donor crisis
5. Protein translation in sperm
6. How sperm crack the whip
7. Chromosomal abnormalities in sperm higher after vasectomy reversal
8. Ecologists home in on how sperm whales find their prey
9. Study links high levels of nitric oxide to infertility and sperm DNA damage
10. Even when faint, ovary scent draws sperm cells
11. Single molecular mark seen as pivotal for genome compaction in spores and sperm

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/12/2017)... SAN DIEGO , Jan. 12, 2017  Trovagene, ... circulating tumor DNA (ctDNA) technologies, today announced that it ... Europe and the Middle ... biopsy tests.  This milestone marks the first wave of ... tests for urine and blood samples. The ...
(Date:1/6/2017)... , Jan. 6, 2017  Privately-held CalciMedica, ... studies in healthy volunteers of a novel calcium ... treat acute pancreatitis. Acute pancreatitis, ... a mild disorder, but can be very serious.  In ... and sepsis, where extended hospital stays, time in ...
(Date:1/3/2017)... 3, 2017 Onitor, provider of digital health ... Track, an innovative biometric data-driven program designed to aid ... at the 2017 Consumer Electronics Show (CES) in ... the U.S., the World Health Organization (WHO), have identified ... adults who are overweight or obese. WHO also states ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... PA (PRWEB) , ... January 18, 2017 , ... ... operations again at the CHI SCOPE Summit for Clinical Ops Executives (Hyatt Regency ... engaging panel discussions to examine vital clinical research issues such as trial performance ...
(Date:1/18/2017)... , ... January 18, 2017 , ... Thirty-six startup companies ... credits by the Pennsylvania Department of Community and Economic Development in 2016 as part ... located in the University City Keystone Innovation Zone and represent the highest number of ...
(Date:1/18/2017)... , Jan. 18, 2017  Caris Life Sciences, ... Lustgarten Foundation, the largest private funder of pancreatic ... trial evaluating the impact of immunotherapy in the ... trial enrollment services to identify potential trial candidates ... between treating physicians and study investigators. The Lustgarten ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... (RF) to its VALIDATE® SP2 calibration verification / linearity test kit. VALIDATE® SP2 ... base. Each VALIDATE® SP2 kit is prepared using the CLSI recommended “equal delta” ...
Breaking Biology Technology: