Navigation Links
Early-stage immune system control of HIV may depend on inherited factors

How well an individual's immune system controls HIV during the earliest phases of infection appears to depend on both the specific versions of key immune-system molecules called HLA Class I that have been inherited, as well as on the fragments of viral protein those molecules display to the T lymphocytes that usually destroy infected cells. In a report in the November issue of PLOS Medicine, researchers from the Partners AIDS Research Center at Massachusetts General Hospital (PARC/MGH) report that specific HLA Class I/HIV viral fragment combinations are associated with a more powerful antiviral response, findings that may help develop vaccines against HIV.

"We found that only a limited number of viral protein fragments from HIV-1 are targeted by the immune system in early infection and that the versions of HLA Class I previously associated with slower HIV-1 disease progression also contribute more to this initial antiviral immune response," says Marcus Altfeld, MD, PhD, of PARC/MGH, the paper's lead author.

An essential aspect of the immune response involves educating T cells to recognize pathogens or other "non-self" proteins. This is done by means of human leukocyte antigen (HLA) receptors that sit on the surface of virtually every cell. Immune system cells that ingest bacteria or parasites digest those pathogens and display protein fragments on their surface membranes via HLA Class II proteins. Virally infected cells display viral proteins on HLA Class I molecules, which activate the CD8 cytotoxic T lymphocytes that usually destroy infected cells. Although the CD8 response against HIV is ultimately ineffective in protecting infection, several studies have suggested that it plays a key role in determining how quickly the disease progresses after initial infection.

HLA ?also called major histocompatibility complex (MHC) ?proteins are also the primary markers of tissues as "self." Unique to each individual, these are the factors tha
'"/>

Source:Massachusetts General Hospital


Page: 1 2 3

Related biology news :

1. Early-stage sperm cells created from human bone marrow
2. Fox Chase Cancer Center scientists identify immune-system mutation
3. Genetically modified natural killer immune cells attack, kill leukemia cells
4. Studies reveal methods viruses use to sidestep immune system
5. Jumping gene helps explain immune systems abilities
6. Scientists solve structure of key protein in innate immune response
7. Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
8. NYU study reveals how brains immune system fights viral encephalitis
9. Chemists identify immune system mechanism for methamphetamine binges
10. Multi-purpose protein regulates new protein synthesis and immune cell development
11. Genetic defects give the immune system the green light to attack the pancreas
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Early stage immune system control HIV may depend inherited factors

(Date:10/15/2014)... Life, is a non-traditional biophysics textbook and it describes ... a journey of discovery into biological systems and provides ... regulation. It is about how our genes make proteins ... billions of cells in an organism. It quantifies the ... which can be found on both large and small ...
(Date:10/15/2014)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ("NXT-ID" or ... commerce market releases photos and video of the recent opening bell ... th . Gino Pereira , CEO of ... Mr. Chad A. Verdi rang the bell.  ... and employees "for their work and dedication in bringing the world,s ...
(Date:10/14/2014)... A new study published in Cancer Research ... liver and colon cancers—can promote the development of skin ... proliferation and survival of sun-damaged skin cells. , Previously ... seven proteins called sirtuins that help regulate genomic stability ... aging. SIRT6 helps repair DNA damage, which can lead ...
Breaking Biology News(10 mins):New book about life as seen from physics 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
... can make a big difference. A "left-handed" molecule of ... while its mirror-image "right-handed" counterpart could be completely inactive. ... are crucial: Living organisms are made only from left-handed ... difficult. Now, a team of scientists at the ...
... Philadelphia, PA, June 28, 2013 For the first ... among critically ill children in a new report published ... and Dietetics . This study also showed the ... Providing early nutritional support through the intestine, or ...
... the first public health study of the aerial mosquito ... Davis study analyzed emergency department records from Sacramento area ... summer of 2005. Physicians and scientists from the university ... no increase in specific diagnoses that are considered most ...
Cached Biology News:Tiny nanocubes help scientists tell left from right 2Tiny nanocubes help scientists tell left from right 3Registered dietitians help critically ill children get necessary nutrition for recovery 2Aerial mosquito spraying study finds no immediate public health risks 2Aerial mosquito spraying study finds no immediate public health risks 3
(Date:10/20/2014)... The report “Pharmacy Automation Systems Market by ... Systems, Table-top Counters) by End-user (Inpatient Pharmacy Automation, ... to 2019” analyzes and studies the major market ... Asia-Pacific, and the Rest of the World (RoW). ... spread through 300 pages and in-depth TOC on ...
(Date:10/20/2014)... , A major pan-European survey ... delivery of care has revealed changing trends in many ... the provision of healthcare services across the continent. The ... European Gastroenterology (UEG), have been announced today and led ... the burden of GI disorders across Europe ...
(Date:10/20/2014)... 2014 Local veterinary surgeon, Dr. Tim ... study of donor stem cells for dogs with osteoarthritis. ... and has performed clinical stem cell therapy for 7 ... determine if a single injection of donor stem cells ... reduce pain and inflammation in the treated joints. ...
(Date:10/19/2014)... 2014 The Asian Automatic patient billing ... analysis and forecast of revenue. The Automatic patient billing ... $463.9 million by 2018, at a developing CAGR of ... TOC of the Asian Automatic patient billing market, to ... also provides a glimpse of the segmentation of this ...
Breaking Biology Technology:Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3
... Veteran healthcare executive brings solid experience with international ... healthcare and technology companies, ... management tools, announced the appointment of,Guillermo Moreno as its vice ... for developing and implementing strategic,initiatives to grow the company,s business ...
... Corporation,(Nasdaq: SIAL ) will be presenting at the ... at 8:30 AM ET at the Grand Hyatt in,New ... broadcast over the,Internet available at http://ir.sigmaaldrich.com . Users ... the webcast on, http://ir.sigmaaldrich.com users will need to ...
... FREMONT, Calif., Sept. 17 Quark ... and developing novel,RNA interference (RNAi)-based therapeutics, ... the 5th Annual RNAi Europe, taking ... Three of Quark,s scientists,Igor Mett, Hagar ...
Cached Biology Technology:Guillermo Moreno Named Aurillion's Vice President of Sales and Marketing 2Quark Pharmaceuticals Announces Poster Presentations at RNAi Europe 2008 2Quark Pharmaceuticals Announces Poster Presentations at RNAi Europe 2008 3
...
Chicken polyclonal to ADI1 ( Abpromise for all tested applications). Antigen: Full length native protein (purified), corresponding to amino acids 1-179 of Human ADI1. Entrez GeneID: 55256 ...
ABI Plant AFLP Kits • EcoRI-ACA AFLP Amplification Primers...
Lipid-rich bovine serum albumin for cell culture. It is chromatographically purified and has an IgG content 1.0% (w/w)....
Biology Products: