Navigation Links
EGF receptor activation prevents microbes from going more than skin deep

Our skin not only serves as a physical barrier against infection but skin cells themselves can mount an immune response to kill invading microbes by producing antimicrobial polypeptides (AMPs).

As overt infection in the skin is a rare event, researchers have theorized that AMPs must not only help fight infection, but play a role in preventing infection from developing in the first place. In a study appearing online on June 15 in advance of print publication in the July issue of the Journal of Clinical Investigation, Ole Sorensen and colleagues from Lund University, Sweden, investigated what triggers AMP production in human skin. Interestingly, they found that AMPs were produced in human skin after sterile wounding of the skin surface, illustrating that exposure to invading microbes is not the sole trigger for the immune response in skin.

The authors went on to show that AMP was produced through activation of the epidermal growth factor receptor (EGFR), which is known to play a role in the normal wound-healing process. The authors found that the antibacterial activity of the skin against the potential skin pathogen Staphylococcus aureus was increased by activation of EGFR, and that the concentrations of AMPs in the epidermis of wounded skin exceeded those necessary to suppress or prevent the growth of foreign microbes. The results of this study demonstrate that wounding of the skin alone, without the presence of microbes, is sufficient to activate defense mechanisms in the skin that can prevent microbial growth and related harmful skin infections.


'"/>

Source:Journal of Clinical Investigation


Page: 1

Related biology news :

1. Activation of thermoreceptors mediates raw garlics burning pungency
2. Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage
3. Small worm yields big clue on muscle receptor action
4. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
5. Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
6. Bats use touch receptors on wings to fly, catch prey, study finds
7. HIV accessory protein disables host immunity via receptor-protein intermediary
8. Manipulating single cell receptor alters animal behavior
9. Nano-keys bind cell receptors and trigger allergic reactions
10. Variation in bitter-taste receptor gene increases risk for alcoholism
11. Protein receptor cools passion of kiss and run nerve cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/12/2016)... WearablesResearch.com , a brand of Troubadour Research & ... Q1 wave of its quarterly wearables survey. A particular ... a program where they would receive discounts for sharing ... "We were surprised to see that so many ... CEO of Troubadour Research, "primarily because there are segments ...
(Date:4/28/2016)... FRANCISCO and BANGALORE, India , ... of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... provider, today announced a global partnership that will ... way to use mobile banking and payment services. ... is a key innovation area for financial services, but it ...
(Date:4/26/2016)... -- Research and Markets has announced the ...  report to their offering.  , ,     (Logo: ... forecast the global multimodal biometrics market to grow ... 2016-2020.  Multimodal biometrics is being implemented ... healthcare, BFSI, transportation, automotive, and government for controlling ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016  Sequenom, Inc. (NASDAQ: ... enabling healthier lives through the development of innovative products ... the United States denied its ... the claims of Sequenom,s U.S. Patent No. 6,258,540 (",540 ... criteria established by the Supreme Court,s Mayo Collaborative Services ...
(Date:6/27/2016)... PHILADELPHIA , June 27, 2016  Liquid ... today announced the funding of a Sponsored Research ... study circulating tumor cells (CTCs) from cancer patients.  ... changes in CTC levels correlate with clinical outcomes ... therapies. These data will then be employed to ...
(Date:6/24/2016)... ... ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical journal articles ... findings are the subject of a new article on the Surviving Mesothelioma website. ... blood, lung fluid or tissue of mesothelioma patients that can help point doctors to ...
(Date:6/23/2016)... 2016 A person commits a crime, and the ... track the criminal down. An outbreak of foodborne ... Administration (FDA) uses DNA evidence to track down the bacteria ... far-fetched? It,s not. The FDA has increasingly used a complex, ... foodborne illnesses. Put as simply as possible, whole genome sequencing ...
Breaking Biology Technology: