Navigation Links
Dysentery uses 'sword and shield' to cause infection

Scientists have found that the bacterium that causes dysentery uses a 'sword and shield' approach to cause infection.

According to research published today in Science, the team from Imperial College London and Institut Pasteur, Paris, found that shigella, the bacteria which causes dysentery, is able to invade cells, while stopping any response from the immune system.

They found that shigella was able to infect cells by using a secretion system to inject proteins into human cells, (the sword), while lipopolysaccharide (LPS) on the surface of the bacteria acts as a shield to protect the dysentery bacterium from being destroyed by the body's immune system.

Dr Christoph Tang, from Imperial College London, and one of the researchers, comments: "This is the first description of bacteria able to use this 'sword and shield' approach, showing how dysentery is able to infect the body so effectively. We have shown why the bacteria can avoid being destroyed by the body's immune responses through the expression of a molecule that acts as a shield on its surface."

The researchers found that shigella, the bacteria causing dysentery uses a Type III secretion system to inject proteins into human cells. This causes the cells to become inflamed, resulting in symptoms of dysentery, such as bloody diarrhoea. At the same time, the LPS chains on the surface of the bacteria are shortened. This allows the needles to inject proteins, while protecting the bacteria from being destroyed by the immune system.

Dr Tang adds: "This discovery greatly expands our understanding of how bacteria are sometimes able to evolve although it is unlikely to result in new treatments or vaccines for dysentery. In this case, the dysentery bacteria has evolved into a highly effective and dangerous infection."


'"/>

Source:Imperial College London


Page: 1

Related biology news :

1. Scientists detect probable genetic cause of some Parkinsons disease cases
2. BRCA1 causes ovarian cancer through indirect, biochemical route
3. Scientists decipher genome of fungus that can cause life-threatening infections
4. Researchers discover molecule that causes secondary stroke
5. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
6. NASA study finds snow melt causes large ocean plant blooms
7. Emergence of cancer as major cause of childhood death in developing countries is not being adequately addressed
8. UNC launches study of liver injury caused by drugs
9. First technology to remove prions that cause vCJD from blood launched
10. Norovirus found to cause travelers diarrhea
11. Six million Africans face famine because of locusts, drought
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/4/2016)... The field of Human Microbiome research ... popular hubs of the biotechnology industry. While the ... of human microbiota, have garnered a lot of ... space has literally exploded in terms of both ... focuses on biomedical aspects of research, development, and ...
(Date:2/3/2016)... 2016 http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ... "Emotion Detection and Recognition Market by ... Software Tools (Facial Expression, Voice Recognition and ... - Global forecast to 2020" report ... http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ) has announced the addition of ...
(Date:2/2/2016)... YORK , Feb. 2, 2016 Technology Enhancements ... presents an analysis of the digital and computed radiography ... Malaysia , and Indonesia ... trends and market size, as well as regional market ... country and discusses market penetration and market attractiveness, both ...
Breaking Biology News(10 mins):
(Date:2/11/2016)...  Dovetail Genomics™ LLC today announced that it has ... planned metagenomic genome assembly service. Richard Green , ... method in a talk on Friday, February 12 at ... in Orlando, Fla. ... difficult. Using its proprietary Chicago ™ ...
(Date:2/11/2016)... ... February 11, 2016 , ... Global Stem Cells ... with Bankok,Thailand-based Global Stem Cells Network (GSCN) to distribute exosome injection and other ... including Mexico, Costa Rica, Dominican Republic, Colombia, Argentina, Nicaragua, Panama, El Salvador, Venezuela, ...
(Date:2/10/2016)...  The Maryland House of Delegates and House Speaker ... of Maryland School of Medicine Dean E. Albert ... Medical System President and CEO Robert Chrencik , ... honor given to the public by the leader of ... and Mr. Chrencik for their contributions to our ...
(Date:2/10/2016)...  IsoRay, Inc. (NYSE MKT: ISR), a medical technology ... applications for the treatment of prostate, brain, lung, head ... results for the second quarter and six months of ... --> --> Revenue was ... which ended December 31, 2015, a 12% increase compared ...
Breaking Biology Technology: