Navigation Links
Duke Experiments Boost Radiation's Cancer-Killing Effects

or "hypoxic" do not respond as well to radiation and chemotherapy. Blocking HIF-1 production does not increase oxygen levels, but it does alter the behaviors that are caused by hypoxia.

Similarly, tumors with an intact tumor suppressor gene known as p53 respond more readily to radiation and to HIF-1 inhibition than tumors with a mutated P53 gene. Understanding such factors can aid scientists in determining the best conditions under which to inhibit HIF-1.
"We want to maximize the benefits of HIF-1 blockage while minimizing the drawbacks," said Moeller.

Moeller used a unique, targeted approach of blocking HIF-1 in cells to ensure that HIF-1, and not other proteins, was responsible for the effects they saw. He inserted a mutated form of HIF-1 into the cancer cell and turned it on and off by exposing it to the antibiotic tetracycline.

With this reversible switch, the team could observe the effects while HIF-1 was active and when it was blocked. Drugs to block HIF-1 have been used in previous studies conducted at Duke and elsewhere, but such drugs inhibit other proteins as well, making it impossible to distinguish which effects are related to HIF-1 and which are not.

The team's next step is to test the effects of blocking HIF-1 following chemotherapy. The research was funded by the National Cancer Institute, the Howard Hughes Medical Institute and the Aeolus Corporation.


'"/>

Source:DukeHealth


Page: 1 2 3

Related biology news :

1. Experiments provide proof of how traveling in groups protects insects
2. Experiments provide proof of how traveling in groups protects insects
3. Boosting HIV screening can increase survival and is cost effective
4. Brain Scans Reveal How Gene May Boost Schizophrenia Risk
5. Boosting The BCG Vaccine To Beat Tuberculosis
6. Boosting newborns immune responses
7. Boosting brain power -- with chocolate
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Duke Experiments Boost Radiation Cancer Killing Effects

(Date:1/22/2015)... Issued by Small Cap IR. In 2011, Nilson Report,s annual ... merchants on the leading payment cards rose to $135.3 billion ... prepaid cards reached 6.54 billion.  Eight million credit card users ... 2012, and credit and debit card fraud resulted in $11.27 ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... addition of the "Global Wearable Technologies Market ... Share, Overview, Trends and Forecast 2014-2020" report ... Technologies are smart devices that can be worn ...
(Date:1/22/2015)... CHARLOTTE, N.C. , Jan. 22, 2015 Infinisource has ... introduction of the G2 model. The G2 sets a higher ... company,s iSolved human capital management solution. With plug-and-play installation, touch ... G2 time clock provides a robust time collection solution for ...
Breaking Biology News(10 mins):$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2Infinisource's NXG series sets new time clock standard 2
... elected to the National Academy of Sciences. He is ... from 14 countries elected "in recognition of their distinguished ... of active members now stands at 2,179. Asner ... Ecology,s first staff scientist. Since coming to Carnegie, Asner ...
... Chase, MDResearchers claim to have calculated for the first ... above which the associated risk for cardiovascular events or ... for publication in The Endocrine Society,s Journal of ... There is increasing evidence that vitamin D plays a ...
... Ariz., April 30, 2013 Economic growth is expected ... of 2013, say the nation,s purchasing and supply executives ... the remainder of 2013 continue to be positive in ... These projections are part of the forecast issued by ...
Cached Biology News:Carnegie's Greg Asner elected to National Academy of Sciences 2Researchers pinpoint upper safe limit of vitamin D blood levels 2Economic Growth To Continue Throughout 2013 2Economic Growth To Continue Throughout 2013 3Economic Growth To Continue Throughout 2013 4Economic Growth To Continue Throughout 2013 5Economic Growth To Continue Throughout 2013 6Economic Growth To Continue Throughout 2013 7Economic Growth To Continue Throughout 2013 8Economic Growth To Continue Throughout 2013 9Economic Growth To Continue Throughout 2013 10Economic Growth To Continue Throughout 2013 11Economic Growth To Continue Throughout 2013 12Economic Growth To Continue Throughout 2013 13Economic Growth To Continue Throughout 2013 14Economic Growth To Continue Throughout 2013 15
(Date:1/23/2015)... 23, 2015 Portal Solutions , a ... on Microsoft Office 365 and SharePoint platforms , today ... program for being one of the region’s fastest-growing mid-sized companies ... growth. , “To be recognized a second year in ...
(Date:1/22/2015)... Jan. 22, 2015  Transwestern | RBJ today announces the firm ... space for Shire a leading biopharmaceutical company, at Two Ledgemont ... RBJ,s Robert Richards , president, and Brian Cohen ... the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... 21, 2015 Cambridge Semantics, the leading provider ... announced that 2014 was a record-breaking year across the board ... the Anzo Smart Data Platform and our Smart Data solutions, ... from diverse data which led to record growth for the ...
(Date:1/22/2015)... Boulder, CO / Rootstown, OH (PRWEB) January 22, 2015 ... sensitive detection platform, announced today that it has received AOAC-PTM ... O26, O45, O1O3, O111, O121, and O145; collectively referred to ... (E. coli) O157, at 1 colony forming unit (cfu) per ...
Breaking Biology Technology:Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 2Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 3Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Cambridge Semantics Announces Record Results for 2014 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2
... Feb. 10 Microdosing or Phase 0 clinical ... an imperative phase of the drug development process ... niche capability providers in preclinical testing and technology ... partnerships and alliances, fuelling growth opportunities in this ...
... an MBA-student organized event, will be held February 19-20 in Philadelphia. ... from Healthcare Services, Investment, Pharma, Biotech, and Medical Device sectors. ... ... 2009 Wharton Health Care Business Conference , an MBA-student organized ...
... DSM Biologics and Crucell N.V. (Euronext, Nasdaq: ... they have entered into an agreement with Bioceros B.V. ... Under the terms of the agreement, Bioceros will be ... the PER.C6(R) cell line located in the European Union.Karen ...
Cached Biology Technology:Frost & Sullivan Sees Microdosing as Compelling Advantage for Big Pharma 2Frost & Sullivan Sees Microdosing as Compelling Advantage for Big Pharma 314th Annual Wharton Health Care Business Conference to Feature CEOs from WebMD, McKesson, Humana and Given Imaging 2DSM and Crucell Sign Agreement with Bioceros to Serve as Pre-Approved Cell Line Generation Partner of PER.C6(R) Cell Line Proteins 2DSM and Crucell Sign Agreement with Bioceros to Serve as Pre-Approved Cell Line Generation Partner of PER.C6(R) Cell Line Proteins 3DSM and Crucell Sign Agreement with Bioceros to Serve as Pre-Approved Cell Line Generation Partner of PER.C6(R) Cell Line Proteins 4DSM and Crucell Sign Agreement with Bioceros to Serve as Pre-Approved Cell Line Generation Partner of PER.C6(R) Cell Line Proteins 5
... solution is a highly scalable analysis ... data in a workgroup or an ... over 40 leading pharmaceutical, biotechnology, academic ... Workgroup streamlines genomics research at large ...
... Process Control at its Best: ... Real-Time Monitoring, Online Changes & comprehensive ... range of parameters auch as pH, ... are accessible and changeable online. Profiles, ...
... genome-wide microRNA (miRNA) expression profiling service using ... enable highly sensitive and specific direct detection ... for mature miRNA of all species available ... miRBase database (Release 8.2). Our service is ...
... acid synthetic peptide whose sequences are derived from mouse resistin protein. ... S(21) - S - M - P - L - C ... I - D - K - K - I - K ... be used for neutralization and control experiments with the polyclonal antibody ...
Biology Products: