Navigation Links
Duke Experiments Boost Radiation's Cancer-Killing Effects

nd re-growth by inhibiting HIF-1," said Moeller.

Conversely, when the scientists blocked HIF-1 before radiation, there was no overall inhibition of tumor growth. The tumor's center became "necrotic" or populated with dead cells, but the perimeter of the tumor continued to grow.

In fact, blocking HIF-1 before radiation was detrimental to radiation's effects: it prevented cancer cells from engaging in the very behaviors that radiation targets for destruction, said Dewhirst.

"HIF-1 assists cancer cells in dying by a process of self-directed suicide called 'apoptosis,'" said Dewhirst. "If HIF-1 is inhibited prior to radiation, it will make the cell less sensitive to apoptosis and will thereby make the tumor cells more resistant to radiation."

Moreover, because radiation itself boosts HIF-1 levels, blocking HIF-1 at the height of its activity ?after radiation has occurred -- is the most logical sequence of therapy, said Dewhirst.

HIF-1 has become the focus of numerous anti-cancer therapies worldwide, said Dewhirst. Yet its impact on cancer cells is so diverse ?it regulates more than 70 genes -- that simply blocking its activity without regard to its myriad effects has yielded conflicting results. Some of HIF-1's effects promote cancer, while others inhibit cancer, so it is critical to block the protein at a juncture where it promotes cancer growth.

The environment inside the tumor ?and the timing of a given treatment -- can make all the difference in a tumor's response to that therapy, said Moeller.

"Just as putting on a coat and gloves in the middle of summer would yield no benefit and could actually cause harm, blocking HIF-1 at the wrong time and place produces no benefit," said Moeller. "But blocking HIF-1 in the right environment can dramatically inhibit the growth of new blood vessels that feed the tumor."

A multitude of factors influence how HIF-1 behaves in a cancer cell. Cells that are low in oxygen
'"/>

Source:DukeHealth


Page: 1 2 3

Related biology news :

1. Experiments provide proof of how traveling in groups protects insects
2. Experiments provide proof of how traveling in groups protects insects
3. Boosting HIV screening can increase survival and is cost effective
4. Brain Scans Reveal How Gene May Boost Schizophrenia Risk
5. Boosting The BCG Vaccine To Beat Tuberculosis
6. Boosting newborns immune responses
7. Boosting brain power -- with chocolate
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Duke Experiments Boost Radiation Cancer Killing Effects

(Date:7/9/2014)... Calif. Sexual selection refers to species, selection for ... special type of natural selection enhances opportunities to mate, ... , Biologists at the University of California, Riverside have ... formation of a placenta are linked. Describing the ... in the family Poeciliidae, the researchers found that species ...
(Date:7/9/2014)... nature,s ability to split the water molecule during ... artificial photosynthesis for clean, green and renewable energy ... scientists led by researchers with the Lawrence Berkeley ... Accelerator Laboratory. , Working at SLAC,s Linac ... x-ray laser, the researchers were able to take ...
(Date:7/9/2014)... studying critically ill children with traumatic injuries have ... are likely to develop a hospital-acquired infection. The ... and published online in June in the journal ... efforts that could lead to the clinical implementation ... prevent or reverse immune system damage following critical ...
Breaking Biology News(10 mins):Biologists link sexual selection and placenta formation 2Biologists link sexual selection and placenta formation 3Biologists link sexual selection and placenta formation 4Postcards from the photosynthetic edge 2Postcards from the photosynthetic edge 3Immune function predicts infection risk among child trauma patients 2Immune function predicts infection risk among child trauma patients 3
... lesson or two from tiny cells on how to maximize ... at Chicago have found that intra-cellular trafficking is tightly coordinated ... on a crowded road are allowed to pass quickly through ... molecular mechanism that underlies this coordination is reported by lead ...
... for over 50 years that moths can hear the ultrasonic ... are among the simplest in the insect world—they have only ... Previously, it was thought that these ears were only partially ... it would seem likely that by using high ultrasound, bats ...
... a medical case of Jekyll and Hyde, carbon monoxide ... faulty heating systems ?has proven effective in treating the ... condition that typically leads to right heart failure and ... animal study led by researchers at Beth Israel Deaconess ...
Cached Biology News:Molecular mechanism provides intra-cellular traffic signal 2Therapeutic role found for carbon monoxide 2Therapeutic role found for carbon monoxide 3
(Date:1/15/2014)... the device," Nobel laureate Herbert Kroemer famously observed, ... at the junctures where layers of different materials ... interfaces between layers of metal oxides are becoming ... as spintronics, high-temperature superconductors, ferroelectrics and multiferroics. Realizing ...
(Date:1/15/2014)... FALLS, N.Y., Jan. 15, 2014   Niagara Thermal ... been selected by Buffalo BioBlower Technologies LLC ("B3") as ... SBIR Phase 2 award from the Army Corps of ... system that kills all biological contaminants and destroys VOCs ...
(Date:1/15/2014)... JOSE, California , January 15, 2014 ... cancer, today announced the appointment of Thomas C Reynolds MD, ... 20 years, development experience gained in the biotechnology industry, most ... "I am delighted to welcome Tom at this transformative time ...
(Date:1/15/2014)... , January 15, 2014 A study ... races on the Formula 1 track could help to tackle ... Applied Technologies (MAT), Stowhealth (a GP surgery based in Stowmarket) ... healthcare provider Simplyhealth. Telemetry technology, which is inspired ...
Breaking Biology Technology:A deeper look at interfaces 2Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4
... ... ... -- MODA Technology Partners will offer a live, interactive Webinar on the benefits and value ... 9:00 AM MT). The presentation will feature Marvin Thompson, Manager, Quality Operations at Talecris, and ...
... U.S. Department of Energy,s Argonne National Laboratory will ... in Electrochemical Energy Storage Beyond Lithium Ion: Computational ... electronics and renewable energy applications. Registration ... next generation of high-performance battery technologies is likely ...
... ... MM-111 breast cancer study in combination with trastuzumab. , ... Cambridge, MA (PRWEB) April 17, 2010 -- Merrimack ... the two lead candidates in the company’s pipeline of five novel cancer antibodies, at ...
Cached Biology Technology:Live Webinar: Paperless QC Micro Implemented by Talecris Biotherapeutics 2Live Webinar: Paperless QC Micro Implemented by Talecris Biotherapeutics 3Merrimack to Present Pre-Clinical Data on MM-121 and MM-111 at the 101st Annual Meeting of American Association for Cancer Research (AACR) 2Merrimack to Present Pre-Clinical Data on MM-121 and MM-111 at the 101st Annual Meeting of American Association for Cancer Research (AACR) 3
Recommend to use at 1000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.)...
... kit contains 5 ml CELLection Dynabeads (4.5 ... the human epithelial antigen EpCAM and DNase ... log enrichment of epithelial tumour cells directly ... cells clumps can be enriched from bone ...
... Cy3 Ab Labeling Kit, 1 kit. ... with CyDye fluorescent dyes. Conjugations are ... complete within 1 h. Dyes are ... to ensure consistent labelings. Category: Blotting ...
PHOTOMAN DIRECT COPY CAMERA, 1 EA. Category: Nucleid Acid Detection Systems....
Biology Products: