Navigation Links
Duke Experiments Boost Radiation's Cancer-Killing Effects

Scientists have shown they can dramatically enhance radiation's cancer-killing effects by blocking a "master switch" in cancer cells that promotes cancer growth. Blocking a protein called HIF-1 after radiation therapy doubled the length of time it took for human cancers to begin growing again in mice, said the radiation biologists from the Duke Comprehensive Cancer Center.

Each therapy alone had limited or no benefit on the tumor, because tumors are skilled at circumventing individual therapies and finding new ways to grow. But together, the two therapies more potently inhibited a tumor's ability to sustain and nourish itself by growing new blood vessels around the tumor.

Most importantly, the scientists clarified how this master switch, Hypoxia Inducible Factor or HIF-1, promotes a cancer cell's ability to grow, nourish, energize and develop blood vessels that support its growth.
The answers they yielded are complex, yet promising, for the future treatment of cancer patients, said Mark Dewhirst, Ph.D., DVM, professor of radiation oncology at Duke.

Results of the research, led by Dewhirst and conducted by M.D./Ph.D. candidate Ben Moeller, will be published in the August 15, 2005, issue of Cancer Cell.

"We've shown that blocking HIF-1 at the wrong time therapeutically in a cancer cell yields no benefit and can actually impede other cancer treatments," said Dewhirst. "But when we block HIF-1 at the appropriate time, it substantially increases a tumor's response to radiation therapy."

Specifically, they found that blocking HIF-1 immediately after radiation prevented new blood vessels from developing and nourishing cancer cells that survived radiation. Two days after tumors were irradiated, there was almost no detectable vasculature ?blood vessels feeding the tumor.

"We've employed a treatment strategy where we accomplish two hits ?killing the cancer cells with radiation and then blocking their blood vessel survival a
'"/>

Source:DukeHealth


Page: 1 2 3

Related biology news :

1. Experiments provide proof of how traveling in groups protects insects
2. Experiments provide proof of how traveling in groups protects insects
3. Boosting HIV screening can increase survival and is cost effective
4. Brain Scans Reveal How Gene May Boost Schizophrenia Risk
5. Boosting The BCG Vaccine To Beat Tuberculosis
6. Boosting newborns immune responses
7. Boosting brain power -- with chocolate
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Duke Experiments Boost Radiation Cancer Killing Effects

(Date:8/28/2014)... Oregon, northern California, and Alaska totaled 515 million board ... an increase of more than 10 percent compared to ... Pacific Northwest Research Station reported today. During this same ... to 247 million board feet. , The total value ... percent to $390 million in the same quarter, while ...
(Date:8/28/2014)... Ludwig-Maximilians-Universitaet (LMU) in Munich have assigned a number ... predatory arthropods. These animals lived in shallow marine ... forms found in Jurassic strata. , Before ... marine habitat and were fossilized some 435 million ... of the Silurian seas although they were ...
(Date:8/27/2014)... fungal cell or bacterial colony exerts on a plant cell ... in setting up some of the most fundamental symbiotic relationships ... of a stretch to say that plants may have never ... touch of beneficial fungi, according to a new study led ... of Wisconsin-Madison. , "Many people have studied how roots ...
Breaking Biology News(10 mins):West coast log exports up, lumber exports down in second quarter of 2014 2Paleontology: Oldest representative of a weird arthropod group 2A touching story: The ancient conversation between plants, fungi and bacteria 2A touching story: The ancient conversation between plants, fungi and bacteria 3
... Stem cells are ideal tools to understand disease and develop ... necessary quantities. In particular, generating induced pluripotent stem (iPS) cells ... cells into iPS cells requires many steps and the efficiency ... a few iPS cells even if they started with a ...
... environmental, economic and social problem worldwide as their abundance ... such as nutrient cycling. Despite substantial research, little is ... over native plants that technically should have the advantage. ... these plants are more abundant in introduced versus native ...
... protect themselves against plant-eating animals, and many flowering plants ... bees from taking too much pollen. Now ecologists have ... chemical defences to protect their pollen from some bees. ... Ecological Society,s journal Functional Ecology . In ...
Cached Biology News:MicroRNA cocktail helps turn skin cells into stem cells 2Home and away: How do invasive plant species dominate native species? 2Secret life of bees now a little less secret 2
(Date:8/28/2014)... 28, 2014  Next month, executives from clinical trial marketing ... events beginning with Patient-Centered Clinical Trials 2014 , to ... Boston , September 4-5. Patient recruitment experts Bonnie ... Fleishman will share insights on the benefits of employing ... tactics – from media to mobile apps – can be ...
(Date:8/28/2014)... Scientists, researchers, and technologists will converge in ... 2014 symposium. Marking its 46th year, the annual ... 14-17 September. The event is sponsored by SPIE, ... The premier conference for basic and applied issues which ... will engage researchers and engineers from numerous industries and ...
(Date:8/28/2014)... Whitehouse Laboratories is excited to announce ... PTI Inspection Systems that will enable it ... art leak testing method development and validation programs using ... As part of this agreement, Whitehouse Labs has taken ... Instrument developed and manufactured by PTI. The HVLD ...
(Date:8/27/2014)... , Aug. 27, 2014 ... report is available in its catalogue: ... http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html ... are materials that are readily decomposed by ... from conventional non-degradable packaging in terms of ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7
... care start-ups continued to show strength in the third ... than in the second quarter, compared to just a ... Care Venture Investment Report released by BioEnterprise . ... all towards the end of their investment cycles, there ...
... with the recently developed APR reactor UW-Madison Chemical and Biological ... stem cell pioneer James Thomson won one of these. In 2003, ... might be James Dumesic and Randy Cortright. , ,On November 14, ... New York-based World Technology Network , which calls itself a ...
... Former Wisconsin Governor and U.S. Department of Health ... the World Congress on Information Technology at its ... Deloitte Center for Health Solutions , will speak during ... ,In addition to healthcare, the other main topics will be ...
Cached Biology Technology:Wisconsin scientists to be recognized for innovative biofuel technology 2Wisconsin scientists to be recognized for innovative biofuel technology 3
Mouse monoclonal antibody raised against a partial recombinant COG2. NCBI Entrez Gene ID = COG2...
Mouse polyclonal antibody raised against a partial recombinant AGTRAP. NCBI Entrez Gene ID = 57085...
Mouse polyclonal antibody raised against a partial recombinant NCLN. NCBI Entrez Gene ID = 56926...
...
Biology Products: