Navigation Links
Drug resistant avian influenza viruses more common in Southeast Asia than North America

ains isolated from 1979-83 in the northeastern United States and Southeast Asia. However, 31 percent of H5 and 11 percent of H9 influenza viruses from Southeast Asia isolated in 2000�{04 carried M2 mutations. Isolates of H5 and H9 subtypes from North America during that time remained sensitive to amantadine, while 16 percent of H7 isolates were resistant to this drug.

"These data are clear and convincing," said Elena A. Govorkova, Ph.D., of the St. Jude Infectious Diseases department, a co-author of the paper. "The specific amantadine-resistance mutations in M2 that we identified can occur randomly throughout the world. But we now have solid proof that in Southeast Asia, and especially in China, these mutations are undergoing strong selective pressure."

Selective pressure refers to the extent to which an organism has acquired either a beneficial genetic trait that gives it a survival advantage in a particular environment and therefore makes the organism more likely to survive and multiply; or a trait that makes it vulnerable to something in the environment, and therefore more likely to become extinct.

The increasing incidence of amantadine-resistant H5N1 viruses in China indicates that these variants appear to have survival advantages over the wild, drug-sensitive strains. In addition, the infected birds die so rapidly there is no time for the virus to acquire a large number of mutations, among which could be changes in the M2 protein. Therefore, the high rate of M2 mutations in China probably arises from some human activity that encourages selection of such changes, the researchers said. For example, treating chickens with amantadine to prevent infection with H5N1 would put selective pressure on the M2 gene to acquire mutations that made it resistant to this antiviral drug.

"H5N1 is now endemic-a permanent- resident- in Southeast Asia, including China," Webster said. "Therefore, any selective pressure on this virus ensures plenty of
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2 3 4

Related biology news :

1. NYCs First Rapid HIV Drug-resistant AIDS Case Prompts Call to Step Up HIV Prevention
2. Drug-resistant bacteria on poultry products differ by brand
3. Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia
4. Genetic discovery could lead to drought-resistant plants
5. UF researchers kill resistant bugs one bandage at a time
6. DDT-resistant insects have additional genetic advantage that helps resistance spread
7. New molecule may aid in production of biofuels and fungi-resistant plants
8. Reducing antibiotic use lowers rates of drug-resistant bacteria
9. New class of antibiotics effective against drug-resistant bacteria discovered in fungi
10. Experimental TB drug effective against resistant and latent mycobacterium tuberculosis
11. Virginia Tech helping to develop higher quality, disease-resistant wheat varieties
Post Your Comments:
(Date:10/15/2014)... University Mainz (JGU) as a full member, ensuring ... a significant nationwide standing in the field of ... Gutenberg University Mainz as a full member of ... and international competition for the best minds and ... proud that Mainz University has been recognized as ...
(Date:10/15/2014)...   Neurotechnology , a provider of high-precision ... the VeriLook Surveillance 3.0 software development kit ... face identification using live video streams from single ... version not only identifies faces in a crowd, ... they are moving through the video frame. It ...
(Date:10/14/2014)... is how to produce enough food to feed the ... Agriculture Organization of the United Nations predicts that food ... to feed a growing global population, and plants are ... production. Plants—grains, cereals, fruits, vegetables, and more—feed humans ... must tap into our knowledge of how plants work ...
Breaking Biology News(10 mins):Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3
... Ph.D., of Fred Hutchinson Cancer Research Center, has received ... study the potential role of "genetic conflicts" in the ... colleagues want to find out whether a lost evolutionary ... whether autoimmunity when the body,s immune system turns ...
... PhD candidate has been highly awarded for his innovative image ... Norton, from the Kielpinski group in the Centre for Quantum ... following extensive work on high resolution imaging. Run ... the Extreme Imaging competition aims to promote and celebrate local ...
... French . Vancouver, B.C. -- Marine protected areas ... wrong time. As a result of changing conditions, marine species have been ... per year over the past 50 years, and forecasts of shifts of ... on where to put MPAs weren,t always made with a changing climate ...
Cached Biology News:Did an evolutionary arms race cause lupus? Biologist Harmit Malik receives grant to try and find out 2Extreme imaging wins science praise 2Marine protected areas: changing climate could require change of plans 2
(Date:10/22/2014)... October 22, 2014 Involution Studios ... release of a new infographic, Understanding Ebola . ... a beautifully designed, easy to follow informative tool for ... of outbreak, symptoms and prevention. , "As the news ... the 2014 Ebola outbreak represents not only a healthcare ...
(Date:10/22/2014)... October 22, 2014 According to ... by Service Type (Consulting, Integration, Deployment & Support), ... Deployment Model (Public, Private, Others (Hybrid & Community)) ... defines and segments the Cloud Professional Services Market ... forecasting of revenues. It also identifies the drivers ...
(Date:10/22/2014)... KONG , Oct. 22, 2014  aTyr Pharma ... that rare disease expert John C. McKew , ... McKew brings more than two decades of expertise in ... Institutes of Health, Wyeth Research and Genetics Institute, Inc. ... aTyr,s efforts to expand and translate its novel Physiocrine ...
(Date:10/20/2014)... ON , Oct. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: ... $1.7 million which brings Q3 orders to $5.8 million and provides ... control projects in North America and one ... continue to bid new projects at record levels," said Peter ... were higher at the end of Q3 than they have been ...
Breaking Biology Technology:Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3
... George Bush and Bill Clinton urge Americans to come to aid ... from two former presidents, but because of how they ask people ... and Clinton point viewers to the Web site for the ... of dollars that have streamed in over the Internet since the ...
... Hamlet: Do you see that cloud, thats almost in shape ... a camel, indeed. ,Hamlet: Methinks it is like a weasel. ... a whale? ,Polonius: Very like a whale. , Hamlet ... Shakespeare) , ,Occasionally stumbling across truth but mostly skilled ...
... Controls unveiled its newest products this week at ... The additions to the line are part of the ... ease of use for customers and branching out into ... showed off its latest vehicular battery, designed for hybrid ...
Cached Biology Technology:Outpouring of tsunami relief displays power of the Internet 2Outpouring of tsunami relief displays power of the Internet 3Follow these three rules when choosing tech consultants 2Follow these three rules when choosing tech consultants 3Follow these three rules when choosing tech consultants 4
Antibody specific for trimethyl-Lys27 of histone H3. Mouse monoclonal. Antigen: Synthetic peptide derived from histone H3, trimethylated at lysine 27...
DL-Dithiothreitol (Clelands Reagent) ,PROTEASE FREE!! ,Molecular Biology Grade ,PRODUCT MUST SHIP NEXT DAY DURING HOT SUMMER MONTHS. ,C 4 H 10 O 2 S 2 ,Molecular Weight: 154.25 ,CAS RN: [27565-...
DTT 50 l...
...
Biology Products: