Navigation Links
Drug resistance may travel same path as quorum sensing

The cellular "pumps" associated with multi-drug resistance in bacteria may also be involved in exporting signals responsible for cell-cell communication, a process known as quorum sensing, said researchers from Baylor College of Medicine in a report that appears online today in the Proceedings of the National Academy of Sciences.

"We believe that the drugs exported by these pumps may actually be similar in structure to molecules involved in communicating," said Dr. Lynn Zechiedrich, assistant professor of molecular virology and microbiology at BCM. Thus, the drugs get exported by bacterial cells as if they were the usual communication molecules the cells use to transmit information in a bacterial colony.

While giving a patient a drug starts the process, the bacterial cell is "going down some natural pathway of cell-to-cell communication. It's trying to communicate, and when it does, it increases the number of the pumps to try to send out the molecules. The doctor is trying to kill the bacterial cells with drugs, but the cells just make more pumps to communicate better. The effect is that they get rid of the drug," said Zechiedrich.

Instead of bacterial pumps sending out the usual communication signals, they send out drug instead ?inadvertently blocking the ability of the drug to kill the bacteria. This does not occur because the bacteria "know" that the drugs are going to kill them, but because the drug looks like a communication signal. So the bacterial cells send out what they think is a communication signal, which is bad news for doctors and their patients. This process, known as multidrug resistance, results in the failure to cure the bacterial disease. Even worse, the resistance is not just to one drug, but many because the pump is now increased and many different drugs will be pumped out.

"It compounds the problem," said Zechiedrich. Her findings are a step toward understanding the mystery surrounding drug resistance, she said.< /p>

In her work, she found that two of these "pumps" or transporters ?AcrAB/TolC and NorE ?actually export as yet unidentified signals used in cell-to-cell communication.


'"/>

Source:Baylor College of Medicine


Related biology news :

1. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
2. Researchers make gains in understanding antibiotic resistance
3. MUHC scientists describe genetic resistance to rampant virus
4. New polysaccharide may help combat multidrug resistance in cancer
5. New book explains antibiotic resistance for a broad audience
6. Insects develop resistance to engineered crops
7. Retroviral resistance gene found
8. Drug resistance testing in treatment-naive HIV patients is cost-effective
9. Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance
10. Gaining ground in the race against antibiotic resistance
11. Genes linked to treatment resistance in children with leukemia
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed ... received the prestigious international IAIR Award for the most innovative high security ... ... Maldives Immigration Controller General, ... picture on the right) have received the IAIR award for the "Most ...
(Date:3/22/2017)... 21, 2017   Neurotechnology , a provider ... today announced the release of the SentiVeillance ... improved facial recognition using up to 10 surveillance, ... computer. The new version uses deep neural-network-based facial ... it utilizes a Graphing Processing Unit (GPU) for ...
(Date:3/20/2017)... 2017 PMD Healthcare announces the release of ... Management System (WMS), a remote, real-time lung health monitoring ... Healthcare is a Medical Device, Digital Health, and Chronic ... creating innovative solutions that empower people to improve their ... PMD developed the first ever personal spirometer, Spiro PD, ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... CA, USA (PRWEB) , ... March 29, 2017 , ... ... various regulatory subjects has announced its 3rd Annual Medical Device Summit 2017 venue and ... the Omni Parker House Hotel, in Boston, MA. , The Omni Parker House Hotel, ...
(Date:3/29/2017)... , ... March 29, 2017 , ... ... instrumentation for cell-based assays, disperses a quarterly travel award to noteworthy scientists who ... the company announced that its new round of awards are being given to ...
(Date:3/29/2017)... SAN DIEGO and NEWARK, Del. ... Inc. , a privately-held regenerative medicine company, and ... global materials science company, today announced a collaborative research ... develop novel implantable cell therapy delivery device technologies that ... more than a decade, ViaCyte has been developing innovative ...
(Date:3/29/2017)... The Global Microfluidic Chips Market by Manufacturers, Countries, Type ... study on the existing state of the global Microfluidic Chips industry ... and Asia-Pacific , South ... Africa . ... Browse 172 Tables and Figures, 13 Major Company Profiles, spread ...
Breaking Biology Technology: