Navigation Links
Drug That 'Tags' Decision-making Areas Of The Brain May Aid

Along with aiding efforts to study addicted smokers, a new drug that attaches only to areas of the brain that have been implicated in nicotine addiction may help studies of people battling other disorders such as Alzheimer’s disease and schizophrenia. Developed by UC Irvine Transdisciplinary Tobacco Use Research Center scientists, the new drug ?Nifrolidine ?is a selective binding agent that identifies specific areas of the brain responsible for decision-making, learning and memory. Lead researcher Jogeshwar Mukherjee, UCI associate professor of psychiatry and human behavior, developed Nifrolidine to measure a subtype of nicotine receptors in the living brain by using an imaging technique, positron emission tomography, more commonly known as PET scans. After proving the drug’s effectiveness, Mukherjee believes the drug will have implications for other conditions, as well.

Study results appear in the January issue of the Journal of Nuclear Medicine. “Nifrolidine is suited to provide reliable, quantitative information of these receptors and may therefore be very useful for future human brain imaging studies of nicotine addiction and other clinical conditions in which these brain regions have been implicated,?Mukherjee said. He found in animal tests that Nifrolidine binds to receptors in the temporal and frontal cortex, areas that are responsible for learning and memory as well as reasoning, planning, problem solving and emotion. According to Mukherjee, patients with Alzheimer’s disease have been known to have a 30 percent to 50 percent loss of these receptors “If there is a gradual loss of these receptors over time, Nifrolidine could be a potential marker for early diagnosis of Alzheimer’s disease,?Mukherjee said. Scientists have known that nicotine’s action on these receptors elicits dopamine in various brain regions implicated in nicotine addiction and other disorders. Nicotine acts b y opening specific membrane proteins, called nicotinic receptors, and changing the electrical properties of the cell. The human brain coordinates billions of neurons to mediate complex behaviors such as an infant learning to recognize his or her parents, a senior citizen learning to play piano, or the process of addiction following repetitive exposure to specific drugs. These behaviors all result from the formation of new connections between individual neurons or modifications of existing connections in the brain. “Imaging of nicotine receptors also gives us the potential to study why some people are more addicted to nicotine than others,?Mukherjee said. Additional information : Chattopadhyay S, Xue B, Collins D, Pichika R, Bagnera R, Leslie FM, Christian BT, Shi B, Narayanan TK, Potkin SG, Mukherjee J. Synthesis and Evaluation of Nicotine {alpha}4{beta}2 Receptor Radioligand, 5-(3'-18F-Fluoropropyl)-3-(2-(S)-Pyrrolidinylmethoxy)Pyridine, in Rodents and PET in Nonhuman Primate. Journal of Nuclear Medicine. 2005 Jan; 46(1): 130-140.
'"/>

Source:University of California, Irvine


Related biology news :

1. WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas
2. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
3. Transport System Smuggles Medicines Into Brain
4. Bird Brains Show How Trial and Error May Contribute to Learning
5. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
6. Wiley announces publication of Databasing the Brain
7. Scientists Propose Sweeping Changes to Naming of Bird Neurosystems to Acknowledge Their True Brainpower
8. Brain-mapping technique aids understanding of sleep, wakefulness
9. Some Brain Cells Change Channels To Fine-tune The Message
10. Brain Scans Reveal How Gene May Boost Schizophrenia Risk
11. Brain-injury rehabilitation depends on acetylcholine circuitry

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2017)... , May 5, 2017 RAM ... announced a new breakthrough in biometric authentication based ... quantum mechanical properties to perform biometric authentication. These new ... semiconductor material created by Ram Group and its ... entertainment, transportation, supply chains and security. Ram Group ...
(Date:4/17/2017)... 17, 2017 NXT-ID, Inc. (NASDAQ: NXTD ... filing of its 2016 Annual Report on Form 10-K on Thursday ... ... available in the Investor Relations section of the Company,s website at ... website at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... , Apr. 11, 2017 Research and ... Market 2017-2021" report to their offering. ... The global eye tracking market to grow at a ... report, Global Eye Tracking Market 2017-2021, has been prepared based on ... covers the market landscape and its growth prospects over the coming ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... A ... pregnancy rates in frozen and fresh in vitro fertilization (IVF) transfer ... age to IVF success. , After comparing the results from the fresh and ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights ... (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital ...
(Date:10/10/2017)... International research firm Parks Associates announced today that Tom ... 2017 Annual Meeting , October 11 in Scottsdale, Arizona ... and how smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... ... recipients of 13 prestigious awards honoring scientists who have made ... in a scheduled symposium during Pittcon 2018, the world’s leading conference and exposition ...
Breaking Biology Technology: