Navigation Links
Driver of anthrax toxicity could lead to late-stage therapy

A study in the March 24 Cell reports the discovery of a gene that drives anthrax bacteria's toxic effects. The gene could offer a potential new target for countermeasures against the lethal toxin, according to the researchers.

Such therapies might have the potential to protect against anthrax during the late stages of the disease, after antibiotics have lost their therapeutic value, they added.

The team found that human cells deficient in the so-called LDL receptor-related protein (LRP6) become resistant to anthrax toxin. Furthermore, antibodies against LRP6 protected cells from anthrax toxicity, reported study authors Wensheng Wei and Stanley Cohen of the Stanford University School of Medicine in collaboration with others at Stanford and the National Institutes of Health. The level of anthrax protection afforded by the antibodies rose with increasing dose.

Anthrax is a lethal disease of humans and other animals caused by the spore-forming bacteria Bacillus anthracis, which has been the focus of biological interest and bioterrorism concern. The virulence of the bacteria depends on separate complexes formed by interaction of a carrier protein, protective antigen, with lethal and edema factors responsible for the toxic effects and swelling that impairs the host's immune response.

In the current study, the researchers inactivated genes randomly in human cells. They then examined the mutated cells for resistance to anthrax toxin in an effort to identify host genes that have important roles in infection, with the hope of finding possible new targets for therapies aimed at the host instead of the bacteria. The method allows for the identification of required host cell genes without pre-conceptions about their potential to play a role, the study authors said.

The study revealed that LRP6 acts as a co-receptor, enabling cells to take up anthrax toxin through its interactions with two distinct cell- surface proteins earlier shown to bi
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Scientists seek answers on what activates deadly anthrax spores
2. Antibodies from plants protect against anthrax
3. Defensins neutralize anthrax toxin
4. Critical step traced in anthrax infection
5. US Army plans to bulk-buy anthrax
6. New antibody shows promise as cure for anthrax
7. Effective, safe anthrax vaccine can be grown in tobacco plants
8. UCSD study finds anthrax toxins also harmful to fruit flies
9. Scientists design potent anthrax toxin inhibitor
10. Newly discovered protein kills anthrax bacteria by exploding their cell walls
11. Combating anthrax: Results of study published this month as researchers look for a better vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Driver anthrax toxicity could lead late stage therapy

(Date:2/11/2015)... 2015 According to ... Market by Product (Cards and Readers, Biometrics, Controllers, Management ... Industrial, Healthcare, Education) and By Geography - Global Forecast and Analysis ... Access Control Market is expected to reach ... CAGR of 10.6% between 2014 and 2020. ...
(Date:2/5/2015)... PARK, N.C. , Feb. 5, 2015  Marken ... specialist logistics company and has launched a new marketing ... Clinical Logistics Organization (CLO).  The new campaign focuses on ... on patient, protocol and shipments. The first ... , aligns Marken,s priorities with its client,s priorities. ...
(Date:2/5/2015)... -- New Market Research Reports Title Global ... 2020 has Been Added to GrandViewReseach.com Report Database ... reach USD 5.10 billion by 2020, according to a ... help identify the site of tissue damage in case ... in medical imaging applications. They have been extensively used ...
Breaking Biology News(10 mins):Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4Marken Launches New Patient-Centric Campaign 2IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 2IR Camera Market Worth $5.10 Billion By 2020: Grand View Research, Inc. 3
... Mich---University of Michigan researchers have determined that most types ... evidence that the deadliest form of skin cancer does ... model. In addition, the researchers found that melanoma ... genes on and off, making the malignant cells a ...
... WASHINGTON Though the massive glaciers of the greater ... steps now to help the region,s communities prepare for ... their lives, according to a new report. Programs that ... needed to adequately address these impacts, the report states. ...
... Ill. University of Illinois researchers are using a new ... in biology the relationship between cell mass and growth ... and bioengineering professor Rashid Bashir, published its results in the ... Academy of Sciences . "It,s merging micro-scale engineering and ...
Cached Biology News:More evidence that melanoma does not conform to the cancer stem cell model 2More evidence that melanoma does not conform to the cancer stem cell model 3Time to prepare for climate change 2Time to prepare for climate change 3Time to prepare for climate change 4Time to prepare for climate change 5Microsensors offer first look at whether cell mass affects growth rate 2
(Date:3/3/2015)... (PRWEB) March 03, 2015 HubCast® Inc. ... Chain, today announced the expansion of its Global Print ... print to 850 the world’s largest cities across 75 ... extends to 137 countries providing global enterprises ease, speed, ... procurement process from online order to real-world delivery at ...
(Date:3/3/2015)... 2015  Rosa & Co. LLC, a drug development ... research, today announced it has two posters scheduled to ... Pharmacology and Therapeutics meeting in New Orleans, ... Logo - http://photos.prnewswire.com/prnh/20150302/179058LOGO   Bristol- ... describing a quantitative systems pharmacology approach for immuno-oncology drug ...
(Date:3/3/2015)... New Jersey (PRWEB) March 03, 2015 ... has announced today that it has acquired The ... Terms of the transaction were not announced. , ... services to the energy sector including oil and ... energy, and fossil and nuclear power sectors. The ...
(Date:3/3/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/s3s3t8/personalized ) ... report "Personalized Medicine - Scientific and Commercial ... The aim of personalized medicine or individualized ... the right patient and, in some cases, even ... according to his/her genotype. This report describes the ...
Breaking Biology Technology:HubCast Expands Global Print Supply Chain: Launches New Product Suite 2HubCast Expands Global Print Supply Chain: Launches New Product Suite 3HubCast Expands Global Print Supply Chain: Launches New Product Suite 4Rosa & Co. Announces Two Poster Presentations at the American Society for Clinical Pharmacology and Therapeutics 2015 Annual Meeting 2Rosa & Co. Announces Two Poster Presentations at the American Society for Clinical Pharmacology and Therapeutics 2015 Annual Meeting 3Global Personalized Medicine Market Report 2015 - Scientific and Commercial Aspects 2014-2024 2Global Personalized Medicine Market Report 2015 - Scientific and Commercial Aspects 2014-2024 3
... June 15 Finesse Solutions, LLC, San Jose, CA, a ... its move from a facility in Santa Clara, CA, to ... new address is 71 Daggett Drive, San Jose, CA, 95134. ... from Irvine, CA to Silicon Valley. , , The ...
... MedPredict Market Research, a global provider of pharmaceutical competitive ... entitled "Thought Leader Insight & Analysis: Alzheimer,s Disease," designed ... companies with a stake in the market for diagnostics ... http://www.medpredict.com/website/home.aspx ). , , MedPredict ...
... , - Improving Research ... today announced a new partnership agreement with NextBio,provider of ... discover, and share knowledge locked within public and proprietary,data ... of NextBio,s unique set of ontology-based semantic tools and ...
Cached Biology Technology:New MedPredict Report Reveals Top Alzheimer's Experts' Insights on Diagnostics and Treatments in Development Pipeline 2Elsevier and NextBio Sign Partnership to Enrich ScienceDirect Content, Accelerating Life Sciences, Health Sciences and Chemistry Research 2Elsevier and NextBio Sign Partnership to Enrich ScienceDirect Content, Accelerating Life Sciences, Health Sciences and Chemistry Research 3Elsevier and NextBio Sign Partnership to Enrich ScienceDirect Content, Accelerating Life Sciences, Health Sciences and Chemistry Research 4