Navigation Links
Driver of anthrax toxicity could lead to late-stage therapy

A study in the March 24 Cell reports the discovery of a gene that drives anthrax bacteria's toxic effects. The gene could offer a potential new target for countermeasures against the lethal toxin, according to the researchers.

Such therapies might have the potential to protect against anthrax during the late stages of the disease, after antibiotics have lost their therapeutic value, they added.

The team found that human cells deficient in the so-called LDL receptor-related protein (LRP6) become resistant to anthrax toxin. Furthermore, antibodies against LRP6 protected cells from anthrax toxicity, reported study authors Wensheng Wei and Stanley Cohen of the Stanford University School of Medicine in collaboration with others at Stanford and the National Institutes of Health. The level of anthrax protection afforded by the antibodies rose with increasing dose.

Anthrax is a lethal disease of humans and other animals caused by the spore-forming bacteria Bacillus anthracis, which has been the focus of biological interest and bioterrorism concern. The virulence of the bacteria depends on separate complexes formed by interaction of a carrier protein, protective antigen, with lethal and edema factors responsible for the toxic effects and swelling that impairs the host's immune response.

In the current study, the researchers inactivated genes randomly in human cells. They then examined the mutated cells for resistance to anthrax toxin in an effort to identify host genes that have important roles in infection, with the hope of finding possible new targets for therapies aimed at the host instead of the bacteria. The method allows for the identification of required host cell genes without pre-conceptions about their potential to play a role, the study authors said.

The study revealed that LRP6 acts as a co-receptor, enabling cells to take up anthrax toxin through its interactions with two distinct cell- surface proteins earlier shown to bi
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Scientists seek answers on what activates deadly anthrax spores
2. Antibodies from plants protect against anthrax
3. Defensins neutralize anthrax toxin
4. Critical step traced in anthrax infection
5. US Army plans to bulk-buy anthrax
6. New antibody shows promise as cure for anthrax
7. Effective, safe anthrax vaccine can be grown in tobacco plants
8. UCSD study finds anthrax toxins also harmful to fruit flies
9. Scientists design potent anthrax toxin inhibitor
10. Newly discovered protein kills anthrax bacteria by exploding their cell walls
11. Combating anthrax: Results of study published this month as researchers look for a better vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Driver anthrax toxicity could lead late stage therapy

(Date:9/18/2014)... disciplines will be celebrated tonight at the third annual ... the health of premature infants and in paving the ... whose work was supported by the National Science Foundation, ... Energy Commission, will be honored at a ceremony at ... group of Members of Congress will be on hand ...
(Date:9/18/2014)... and nitrogen comprise all spheres of our planet. ... caused imbalances and perturbations that resulted in increases ... result in climate changes which influence the complex ... atmosphere. Understanding these feedback mechanisms has become an ... during the past three decades. , In parallel, ...
(Date:9/18/2014)... it that when people are too stressed they are ... the Brain Mind Institute (BMI) at EPFL have just ... between chronic stress and the loss of social skills ... attacks a synaptic regulatory molecule in the brain. This ... Communications . , Carmen Sandi,s team went to ...
Breaking Biology News(10 mins):3rd annual Golden Goose award ceremony honors 8 researchers; Unusual work had big results 2Greenhouse gas research enters a new era 2How stress tears us apart 2
... infected with human immunodeficiency virus (HIV), highly active ... of Kaposi sarcoma and non-Hodgkin lymphoma, according to ... of the Journal of the National Cancer Institute. ... (AIDS) have reported increased risks of several cancers, ...
... phase 3 HIV vaccine efficacy trial are reported in the ... available online. Although the vaccine was ineffective in preventing HIV ... HIV and offers the scientific community a foundation on which ... the United States and the Netherlands and completed in 2003, ...
... University of Pennsylvania School of Medicine have identified a ... Virus (EBV) protein known to be expressed in a ... mechanism by which EBV transforms human B cells from ... to development of B-cell lymphomas. , Erle S. Robertson, ...
Cached Biology News:Antiretroviral therapy may prevent excess risk of some cancers in people with HIV 2HIV vaccine trial breaks ground for future research 2Epstein-Barr virus protein crucial to its role in blood cancers 2
(Date:9/18/2014)... -- DeepResearchReports.com adds "2014 Deep Research Report on ... Deep Research Report on Global and China Sodium ... Photo - http://photos.prnewswire.com/prnh/20140918/147058 ... China Acetic Acid Industry" is a professional and ... and Global Acetic Acid Market. The report ...
(Date:9/18/2014)... Washington, D.C. (PRWEB) September 18, 2014 ... Dick Durbin and Sen. Jim Risch for National Lab ... research projects from across the national laboratory system. Durbin ... Caucus, which aims to increase awareness of the reach ... breakthrough technologies and discoveries to address some of our ...
(Date:9/18/2014)... TX (PRWEB) September 18, 2014 ... a FM-4910 listed material, to stay competitive in ... These high-performance materials ultimately impact product quality ... President and owner. , Established in 1980 in ... strong as many fabricators have left the business. ...
(Date:9/18/2014)... , Pennsylvanie, 18 septembre 2014 ... en 1974, a été depuis 40 ... les évaluations cliniques traditionnelles par des évaluations ... et sur les impacts économiques des traitements. ... A cours d,une récente ...
Breaking Biology Technology:Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 4Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 21974 - 2014 - Mapi fête ses 40 ans 2
... July 28, 2011 As the fight over deficit reform ... Association (NEBA) is urging lawmakers from across the region to ... economy and ensure it doesn,t become a victim of short-sighted ... options for treatment and medications available to seniors, but would ...
... (NASDAQ: ITMN ) today announced that it will ... 4, 2011. A live conference call and webcast will be ... day to discuss business highlights and financial results for the ... To access the live teleconference, dial 888-567-5125 (U.S.) or 706-643-9223 ...
... INDIANAPOLIS, and WALTHAM, Mass., July 28, 2011 ... Eli Lilly and Company (NYSE: LLY ) and ... the companies have submitted their reply to a complete response ... Drug Administration (FDA) regarding BYDUREON™ (exenatide extended-release for injectable suspension), ...
Cached Biology Technology:Biotech Group Warns Proposed Medicare Cuts Could Hurt Critical Sector of New England Economy 2InterMune to Release Second Quarter Financial Results on August 4 2BYDUREON™ Reply Submitted to FDA 2BYDUREON™ Reply Submitted to FDA 3BYDUREON™ Reply Submitted to FDA 4BYDUREON™ Reply Submitted to FDA 5BYDUREON™ Reply Submitted to FDA 6BYDUREON™ Reply Submitted to FDA 7
... applications for the use of small interfering ... via the RNA interference (RNAi) pathway have ... molecular biology fields. siRNA for experimental use ... or enzymatically, and then transfected into the ...
... is commonly used as a fusion partner ... The GSTTag sequence has been reported to ... the solubility of its fusion partners. When ... GSTTag fusion proteins can be purified with ...
a1-Antitrypsin (human, alpha-1 AT)...
... demands of the routine trace metal analytical ... robust and simple to use instrumentation. The ... most challenging sample matrices found in the ... the toughest analytical challenges found in the ...
Biology Products: