Navigation Links
Dopamine drug leads to new neurons and recovery of function in rat model of Parkinson's

In preliminary results, researchers have shown that a drug which mimics the effects of the nerve-signaling chemical dopamine causes new neurons to develop in the part of the brain where cells are lost in Parkinson's disease (PD). The drug also led to long-lasting recovery of function in an animal model of PD. The findings may lead to new ways of treating PD and other neurodegenerative diseases. The study was funded in part by the NIH's National Institute of Neurological Disorders and Stroke (NINDS).

The study suggests that drugs that affect dopamine D3 receptors might trigger new neurons to grow in humans with the disease. Some of these drugs are commonly used to treat PD. The finding also suggests a way to develop new treatments for PD. The results appear in the July 5, 2006, issue of The Journal of Neuroscience.

Parkinson's disease, a progressive neurodegenerative disorder that causes tremors, stiffness, slow movements, and impaired balance and coordination, results from the loss of dopamine-producing neurons in part of the brain called the substantia nigra. While many drugs are available to treat these symptoms during the early stages of the disease, the treatments become less effective with time. There are no treatments proven to slow or halt the course of PD. However, many researchers have been trying to find ways of replacing the lost neurons. One possible way to do this would be to transplant new neurons that are grown from embryonic stem cells or neural progenitor cells. However, this type of treatment is very difficult for technical reasons.

The new study, conducted by Christopher Eckman, Ph.D., and Jackalina Van Kampen, Ph.D., at the Mayo Clinic College of Medicine in Jacksonville, Florida, focused on a second possible way to restore function ?prompting stem cells that normally remain dormant in the adult brain to develop into neurons. While most researchers previously believed the adult brain could not develop new neuron
'"/>

Source:NIH/National Institute of Neurological Disorders and Stroke


Page: 1 2 3

Related biology news :

1. Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs
2. Dopamine used to prompt nerve tissue to regrow
3. Study of genomic DNA leads to new advances in cancer diagnostics
4. Combination therapy leads to partial recovery from spinal cord injury in rats
5. Chemical guidance of T cells leads to immunologic memory and long-term immunity
6. Basic research leads to a novel cancer therapy
7. Less antibiotic use in food animals leads to less drug resistance in people, study shows
8. MBL leads effort to update E. coli genome
9. With cochlear implants, earlier use leads to better speech
10. Pest control research leads to pain control discovery
11. UT Southwestern researchers find gene mutation that leads to broken hearts
Post Your Comments:
(Date:4/1/2015)... --  Medisafe ™, the leading global medication management platform ... and Android smartphones and tablets, announces today ... to allow patients to track and correlate their adherence ... will be able to visualize in real-time how taking ... as glucose levels and blood pressure. "Patients ...
(Date:3/31/2015)... YORK , March 31, 2015   Guidepoint ... the launch of the Post-Surgical Pain Management TRACKER, part ... products tracking usage trends in the medical device and ... access to data including treatment volumes, market share, and ... the pain associated with joint surgery. The ...
(Date:3/26/2015)... 26, 2015 The Granite Club, ... and athletic club, today announced it has implemented a ... of movement for members and staff, while restricting access ... process, we selected FST,s IMID Access system because it ... our members and staff, in addition to unparalleled security," ...
Breaking Biology News(10 mins):Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2
... The northern spotted owl, a threatened species in the ... from active management of the forest lands that form ... fire, researchers conclude in a recent study. Whatever ... other fuel reduction activities in areas with high fire ...
... scientific community has always wanted to know why people ... problems such as kidney stones and osteoporosis. , Medical ... this puzzle through their work with animal lab models ... recently discovered an important link between sodium and calcium. ...
... -- The San Francisco State University researchers who accidentally ... want people across the United States and Canada to ... Today SF State Professor of Biology John Hafernik and ... the Center for Computing for the Life Sciences launched ...
Cached Biology News:Active forest management to reduce fire could help protect northern spotted owl 2Diets high in salt could deplete calcium in the body: UAlberta research 2Citizen scientists needed for SF State's 'ZomBee Watch' 2
(Date:4/16/2015)... Morton Grove, IL (PRWEB) April 16, 2015 ... the American Association for Cancer Research (AACR) ... at the Pennsylvania Convention Center, starting Saturday, April 18, ... The AACR holds claim to title of the oldest ... several journals, provides fellowships and grants, and partners with ...
(Date:4/16/2015)... -- In recognition of World Hemophilia Day, Biogen  (NASDAQ: ... more than 15 prominent landmarks red throughout the ... Zakim Bridge and Prudential Tower, Chicago,s ... and Denver,s Coors Field . ... and coincide with hemophilia community events in a dozen locations ...
(Date:4/16/2015)... ChemRar High Tech ... R&D group, and Lancet, Russian Distribution Company, ... commercialization of new medicines in ... stimulate the innovative development of the Russian ... ,     (Logo: http://photos.prnewswire.com/prnh/20150416/739742-b) , Through ...
(Date:4/16/2015)... -- Avelas Biosciences, an in vivo cancer ... that it has initiated a Phase 1b study of ... primary, non-recurrent breast cancer undergoing surgery. In commencing the ... Steven Chen , M.D., as vice president of ... study will enroll up to 39 women with stage ...
Breaking Biology Technology:Regis Technologies Joins American Association for Cancer Research Annual Meeting 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 3Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 4Lancet and ChemRar High Tech Center Have Announced a Partnership in the Development and Production of Novel Drugs in Russia 2Avelas Biosciences Initiates Phase 1b Trial of AVB-620 in Breast Cancer Patients 2Avelas Biosciences Initiates Phase 1b Trial of AVB-620 in Breast Cancer Patients 3
... real environment, the city of Madison. Image courtesy of ... Firefighters need to be fully prepared, practicing hundreds of ... to respond to a chemical spill immediately, getting the ... to work together, planning the best strategy to avoid ...
... ago, a mega-merger of higher education institutions created the University ... insist those who pine for days gone by, but the ... Wisconsins public resources. , ,The time has come for ... time with 21st century realities in mind. Facing a state ...
... announcement that it plans to buy its former parent ... for new opportunities. , ,Drew Petersen, director of legislative affairs ... and AT&T is a sign that SBC plans to become ... TDS, which Petersen said tries to present itself as a ...
Cached Biology Technology:How games have evolved to provide real-world education 2How games have evolved to provide real-world education 3How games have evolved to provide real-world education 4Structural change is coming to the UW System 2Structural change is coming to the UW System 3SBC merger with AT&T could open opportunities in Wisconsin 2