Navigation Links
Dopamine drug leads to new neurons and recovery of function in rat model of Parkinson's

In preliminary results, researchers have shown that a drug which mimics the effects of the nerve-signaling chemical dopamine causes new neurons to develop in the part of the brain where cells are lost in Parkinson's disease (PD). The drug also led to long-lasting recovery of function in an animal model of PD. The findings may lead to new ways of treating PD and other neurodegenerative diseases. The study was funded in part by the NIH's National Institute of Neurological Disorders and Stroke (NINDS).

The study suggests that drugs that affect dopamine D3 receptors might trigger new neurons to grow in humans with the disease. Some of these drugs are commonly used to treat PD. The finding also suggests a way to develop new treatments for PD. The results appear in the July 5, 2006, issue of The Journal of Neuroscience.

Parkinson's disease, a progressive neurodegenerative disorder that causes tremors, stiffness, slow movements, and impaired balance and coordination, results from the loss of dopamine-producing neurons in part of the brain called the substantia nigra. While many drugs are available to treat these symptoms during the early stages of the disease, the treatments become less effective with time. There are no treatments proven to slow or halt the course of PD. However, many researchers have been trying to find ways of replacing the lost neurons. One possible way to do this would be to transplant new neurons that are grown from embryonic stem cells or neural progenitor cells. However, this type of treatment is very difficult for technical reasons.

The new study, conducted by Christopher Eckman, Ph.D., and Jackalina Van Kampen, Ph.D., at the Mayo Clinic College of Medicine in Jacksonville, Florida, focused on a second possible way to restore function ?prompting stem cells that normally remain dormant in the adult brain to develop into neurons. While most researchers previously believed the adult brain could not develop new neuron
'"/>

Source:NIH/National Institute of Neurological Disorders and Stroke


Page: 1 2 3

Related biology news :

1. Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs
2. Dopamine used to prompt nerve tissue to regrow
3. Study of genomic DNA leads to new advances in cancer diagnostics
4. Combination therapy leads to partial recovery from spinal cord injury in rats
5. Chemical guidance of T cells leads to immunologic memory and long-term immunity
6. Basic research leads to a novel cancer therapy
7. Less antibiotic use in food animals leads to less drug resistance in people, study shows
8. MBL leads effort to update E. coli genome
9. With cochlear implants, earlier use leads to better speech
10. Pest control research leads to pain control discovery
11. UT Southwestern researchers find gene mutation that leads to broken hearts
Post Your Comments:
(Date:12/10/2014)... , December 9, 2014 ... BCARD Platform   ... meeting scheduling solutions for business-to-business (B2B) events, today ... leader in mobile near-field communication (NFC), Bluetooth low ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow will ...
(Date:12/3/2014)... Dec. 2, 2014 As part of our ... Technologies is pleased to announce the release of a ... to collect the workforce data that they need. ... been left by existing readers. Many such devices have ... and modern technology. Older models force users to navigate ...
(Date:11/21/2014)...   Atmel® Corporation (NASDAQ: ATML ... technology solutions, today launched the industry,s first family of ... V cc range from 1.7V to 5.5V. The ... 2 C bus communication speeds, and are available with ... ideal for consumer, industrial, computer, and medical applications. ...
Breaking Biology News(10 mins):Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Inception Technologies to Release New Biometric Reader 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4
... The majority of seaports around the world are ... in the coming century, according to a new Stanford ... authorities around the world, the Stanford team found that ... facilities from rising sea levels and more frequent Katrina-magnitude ...
... TORONTO, ON Childhood physical abuse is associated with ... chronic fatigue syndrome, fibromyalgia and multiple chemical sensitivities among ... researchers. The research will be published in this month,s ... Trauma . "Women who reported they had been ...
... This release is available in German . ... successful reproductive strategy for the individual but it can drive ... evolutionary biologist Daniel Rankin from the University of Zurich has ... biologists have long debated whether the behavior of the individual ...
Cached Biology News:Seaports need a plan for weathering climate change, Stanford researchers say 2Seaports need a plan for weathering climate change, Stanford researchers say 3Aggressive male mating behavior can endanger species 2
(Date:12/19/2014)... CA (PRWEB) December 18, 2014 With ... limited time special on Sartorius Biohit products . ... on mLINE pipettes, Picus Electronic Pipette Trade-in Program, and ... Health and Safety officers around the world. They are ... pipetting. Other features include:, ,     Full volume ...
(Date:12/19/2014)... Dec. 18, 2014 Egenix, Inc. is pleased to ... Chairman of the Board, to succeed Donald Fresne ; ... will continue as a member of the Board.  In recognition ... to the company over almost twenty years, the Board designated ... of Directors has established a Search Committee to find a ...
(Date:12/19/2014)... YORK , Dec. 18, 2014 Relmada ... therapies for the treatment of chronic pain, announced the ... today. "This was a transformational year in ... promising future for our company," said Sergio Traversa ... year, we have executed on key financial, human resource ...
(Date:12/17/2014)... 2014 Based on the revenues ... imaging market is dominated by four major players ... market. These players include GE Healthcare (U.K.), Siemens ... , Full Report Copy at http://www.marketsandmarkets.com/Market-Reports/surgical-imaging-market-210534462.html ... can be attributed to its strong product portfolio, ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4
... heard a lot about generic drugs lately. , ,The high ... medical insurance in the U.S. and perhaps even the U.S. governments ... help cap some of the rising costs of health care are ... that 41.2 million Americans or 14.6 percent of the U.S. population ...
... in the biotech and life science industries from the ... part of the JETRO Midwest-Japan Biotechnology Summit. , ,The ... Biotech companies and their counterparts in Japan. The goal ... top accelerate the commercialization of R&D throughout the widest ...
... be illegal , ,While Republican leaders in the ... Jim Doyles Grow Wisconsin program, Sen. Ted Kanavas -- ... with the provisions for the state-funded venture capital authority. ... use of funds from the Patients Compensation Fund ...
Cached Biology Technology:The Generic Drug Industry in Illinois 2The Generic Drug Industry in Illinois 3The Generic Drug Industry in Illinois 4Japan, Midwest Biotechnology Industry Leaders Identify Steps for Greater Collaboration Between Countries 2Republicans criticize Doyles growth package 2Republicans criticize Doyles growth package 3Republicans criticize Doyles growth package 4
Vitronectin Immunogen: Purified, full length, native human protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
... Fully adjustable mixing angle, Variable speed, Digital ... a number of different sized tubes, Spillage ... cultures, keeping biological samples in suspension and ... be used in incubators up to 60C ...
... 2 real-time PCR detection system uses a ... (470-505 nm) and two photomultiplier tubes for ... Opticon 2 system is built on an ... thermal gradient feature. This item includes the ...
Biology Products: